YDR114C_p

Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR114C / YDR114C

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.36|P-value:2.37E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.02|P-value:7.85E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:5.77|P-value:3.54E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.33|P-value:9.36E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.20|P-value:2.13E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.92|P-value:4.95E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:7.35|P-value:3.19E-12 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.53|P-value:4.90E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.19|P-value:3.04E-9 ID:SGTC_565|Compound:1418-0001|FD-Score:3.94|P-value:1.16E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.53|P-value:4.55E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.62|P-value:8.09E-6 ID:SGTC_609|Compound:0986-0026|FD-Score:3.79|P-value:2.03E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.70|P-value:2.82E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.51|P-value:5.31E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.54|P-value:4.74E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.04|P-value:8.09E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.88|P-value:2.63E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.34|P-value:8.37E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.67|P-value:6.54E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.67|P-value:2.82E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.87|P-value:2.76E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.75|P-value:2.37E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.96|P-value:1.08E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.54|P-value:4.86E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.75|P-value:2.30E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.55|P-value:4.65E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.63|P-value:7.20E-8 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.57|P-value:9.71E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.35|P-value:2.92E-7 ID:SGTC_1623|Compound:st003709|FD-Score:4.76|P-value:4.34E-6 ID:SGTC_1624|Compound:st003710|FD-Score:4.47|P-value:1.51E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.63|P-value:3.52E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.43|P-value:6.82E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.72|P-value:2.31E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.83|P-value:1.78E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.10|P-value:6.37E-5 ID:SGTC_1968|Compound:st069590|FD-Score:-4.58|P-value:8.54E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-3.79|P-value:1.81E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.72|P-value:2.35E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.88|P-value:2.55E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.29|P-value:3.89E-7 ID:SGTC_2488|Compound:5268135|FD-Score:4.08|P-value:6.86E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.69|P-value:2.88E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.67|P-value:2.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.51|P-value:5.26E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.44|P-value:6.60E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.29|P-value:9.79E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:3.65E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.86|P-value:1.42E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.37|P-value:8.25E-4 ID:SGTC_2845|Compound:9003024|FD-Score:5.69|P-value:5.30E-8 ID:SGTC_2858|Compound:9025781|FD-Score:-3.35|P-value:8.06E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.55|P-value:4.24E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.57|P-value:4.27E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.90|P-value:1.35E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.72|P-value:5.18E-6 ID:SGTC_3159|Compound:9100096|FD-Score:3.36|P-value:8.51E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.34|P-value:8.35E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.92|P-value:1.27E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.03|P-value:1.30E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-5.57|P-value:8.60E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.36|P-value:2.37E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.02|P-value:7.85E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:5.77|P-value:3.54E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.33|P-value:9.36E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.20|P-value:2.13E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.92|P-value:4.95E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:7.35|P-value:3.19E-12 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.53|P-value:4.90E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.19|P-value:3.04E-9 ID:SGTC_565|Compound:1418-0001|FD-Score:3.94|P-value:1.16E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.53|P-value:4.55E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.62|P-value:8.09E-6 ID:SGTC_609|Compound:0986-0026|FD-Score:3.79|P-value:2.03E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.70|P-value:2.82E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.51|P-value:5.31E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.54|P-value:4.74E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.04|P-value:8.09E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.88|P-value:2.63E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.34|P-value:8.37E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.67|P-value:6.54E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.67|P-value:2.82E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.87|P-value:2.76E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.75|P-value:2.37E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.96|P-value:1.08E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.54|P-value:4.86E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.75|P-value:2.30E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.55|P-value:4.65E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.63|P-value:7.20E-8 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.57|P-value:9.71E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.35|P-value:2.92E-7 ID:SGTC_1623|Compound:st003709|FD-Score:4.76|P-value:4.34E-6 ID:SGTC_1624|Compound:st003710|FD-Score:4.47|P-value:1.51E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.63|P-value:3.52E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.43|P-value:6.82E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.72|P-value:2.31E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.83|P-value:1.78E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.10|P-value:6.37E-5 ID:SGTC_1968|Compound:st069590|FD-Score:-4.58|P-value:8.54E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-3.79|P-value:1.81E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.72|P-value:2.35E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.88|P-value:2.55E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.29|P-value:3.89E-7 ID:SGTC_2488|Compound:5268135|FD-Score:4.08|P-value:6.86E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.69|P-value:2.88E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.67|P-value:2.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.51|P-value:5.26E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.44|P-value:6.60E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.29|P-value:9.79E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:3.65E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.86|P-value:1.42E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.37|P-value:8.25E-4 ID:SGTC_2845|Compound:9003024|FD-Score:5.69|P-value:5.30E-8 ID:SGTC_2858|Compound:9025781|FD-Score:-3.35|P-value:8.06E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.55|P-value:4.24E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.57|P-value:4.27E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.90|P-value:1.35E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.72|P-value:5.18E-6 ID:SGTC_3159|Compound:9100096|FD-Score:3.36|P-value:8.51E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.34|P-value:8.35E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.92|P-value:1.27E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.03|P-value:1.30E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-5.57|P-value:8.60E-8

Top fitness defect scores for YDR114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.20 5.3 µM 2.13E-40 115 7.73E-46
2 SGTC_310 1273-0058 7.35 1.1 µM 3.19E-12 mitochondrial stress 109 9.96E-14
3 SGTC_275 trichlorophene 6.92 5.7 µM 4.95E-11 mitochondrial stress 94 2.26E-12
4 SGTC_173 1273-0061 5.77 2.7 µM 3.54E-8 mitochondrial stress 115 4.02E-9
5 SGTC_2845 9003024 5.69 43.0 µM 5.30E-8 amide catabolism 17 6.37E-9
6 SGTC_1479 0549-0158 5.63 134.0 µM 7.20E-8 4 9.03E-9
7 SGTC_1528 arabinosylhypoxanthine 5.35 74.6 µM 2.92E-7 7 4.44E-8
8 SGTC_2250 alverine citrate 5.29 130.0 µM 3.89E-7 83 6.15E-8
9 SGTC_3223 9129970 5.03 49.5 µM 1.30E-6 9 2.44E-7
10 SGTC_2232 chlorophetanol 4.88 41.5 µM 2.55E-6 TRP & mitochondrial translation 83 5.23E-7
11 SGTC_908 3448-7491 4.88 47.7 µM 2.63E-6 mitochondrial stress 82 5.41E-7
12 SGTC_979 1426-2828 4.87 121.0 µM 2.76E-6 9 5.71E-7
13 SGTC_1623 st003709 4.76 20.3 µM 4.34E-6 calcium & mitochondrial duress 37 9.56E-7
14 SGTC_3154 9100113 4.72 49.5 µM 5.18E-6 14 1.17E-6
15 SGTC_946 3434-1334 4.67 87.4 µM 6.54E-6 16 1.52E-6
16 SGTC_601 0986-0029 4.62 62.9 µM 8.09E-6 calcium & mitochondrial duress 21 1.94E-6
17 SGTC_1501 4491-0275 4.57 38.4 µM 9.71E-6 3 2.39E-6
18 SGTC_1624 st003710 4.47 6.2 µM 1.51E-5 calcium & mitochondrial duress 29 3.94E-6
19 SGTC_118 0083-0097 4.36 135.3 µM 2.37E-5 translation 96 6.59E-6
20 SGTC_2688 kanamycin b 4.25 96.7 µM 3.65E-5 calcium & mitochondrial duress 328 1.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.469 3.05E-183 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.463 9.22E-178 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.460 4.21E-175 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.453 2.71E-169 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.441 1.85E-159 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.439 1.92E-157 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.437 7.18E-156 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.433 9.44E-154 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.423 1.10E-145 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.422 1.01E-144 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.417 5.15E-141 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.412 9.21E-138 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.410 7.46E-136 YMR267W PPA2 hom Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
0.409 2.73E-135 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.404 1.63E-131 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets