YDR117C / TMA64

Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR117C / TMA64

Click on Significant Values for Screen Details ID:SGTC_177|Compound:1327-0068|FD-Score:-3.69|P-value:2.63E-5 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.98|P-value:5.41E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.93|P-value:2.91E-8 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.43|P-value:8.51E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:4.13|P-value:2.72E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.57|P-value:4.22E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.72|P-value:2.17E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.29|P-value:1.45E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:2.88|P-value:7.64E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.07|P-value:3.85E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.25|P-value:1.48E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.04|P-value:4.33E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.06|P-value:3.73E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.35|P-value:1.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.50|P-value:5.24E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.58|P-value:4.38E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.11|P-value:3.30E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.11|P-value:3.25E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.29|P-value:1.55E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.31|P-value:1.38E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.10|P-value:3.20E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.03|P-value:4.47E-4 ID:SGTC_2319|Compound:6033012|FD-Score:6.38|P-value:1.16E-12 ID:SGTC_2327|Compound:6189656|FD-Score:3.00|P-value:4.77E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.06|P-value:3.75E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.46|P-value:6.88E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.05|P-value:4.15E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.03|P-value:4.20E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.88|P-value:9.72E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.09|P-value:3.57E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.45|P-value:7.28E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.96|P-value:6.56E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.42|P-value:8.50E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.14|P-value:2.75E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.00|P-value:4.70E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.05|P-value:4.26E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.81|P-value:9.82E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.24|P-value:1.91E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.11|P-value:3.33E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.16|P-value:2.40E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.05|P-value:3.87E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.64|P-value:3.07E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.69|P-value:2.63E-5 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.98|P-value:5.41E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.93|P-value:2.91E-8 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.43|P-value:8.51E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:4.13|P-value:2.72E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.57|P-value:4.22E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.72|P-value:2.17E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.29|P-value:1.45E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:2.88|P-value:7.64E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.07|P-value:3.85E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.25|P-value:1.48E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.04|P-value:4.33E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.06|P-value:3.73E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.35|P-value:1.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.50|P-value:5.24E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.58|P-value:4.38E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.11|P-value:3.30E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.11|P-value:3.25E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.29|P-value:1.55E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.31|P-value:1.38E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.10|P-value:3.20E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.03|P-value:4.47E-4 ID:SGTC_2319|Compound:6033012|FD-Score:6.38|P-value:1.16E-12 ID:SGTC_2327|Compound:6189656|FD-Score:3.00|P-value:4.77E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.06|P-value:3.75E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.46|P-value:6.88E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.05|P-value:4.15E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.03|P-value:4.20E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.88|P-value:9.72E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.09|P-value:3.57E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.45|P-value:7.28E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.96|P-value:6.56E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.42|P-value:8.50E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.14|P-value:2.75E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.00|P-value:4.70E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.05|P-value:4.26E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.81|P-value:9.82E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.24|P-value:1.91E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.11|P-value:3.33E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.16|P-value:2.40E-6 ID:SGTC_3218|Compound:9131285|FD-Score:3.05|P-value:3.87E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.64|P-value:3.07E-5

Top fitness defect scores for YDR117C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2319 6033012 6.38 152.6 µM 1.16E-12 tubulin folding & SWR complex 12 8.90E-11
2 SGTC_514 4466-0038 4.93 2.6 nM 2.91E-8 cell wall 109 4.06E-7
3 SGTC_928 2764-0428 4.25 58.7 µM 1.48E-6 cell wall 50 1.08E-5
4 SGTC_3217 9129673 4.16 49.5 µM 2.40E-6 33 1.61E-5
5 SGTC_674 0498-0004 4.13 451.0 µM 2.72E-6 heme requiring 22 1.79E-5
6 SGTC_925 2064-1272 4.07 59.6 µM 3.85E-6 21 2.39E-5
7 SGTC_2703 st077852 3.96 53.4 µM 6.56E-6 24 3.73E-5
8 SGTC_2456 5770359 3.88 74.5 µM 9.72E-6 19 5.18E-5
9 SGTC_686 1319-0111 3.72 510.0 µM 2.17E-5 60S ribosome export 35 1.01E-4
10 SGTC_3265 9137266 3.64 49.5 µM 3.07E-5 14 1.35E-4
11 SGTC_676 falcarinol 3.57 140.0 µM 4.22E-5 68 1.77E-4
12 SGTC_2371 9071574 3.46 200.0 µM 6.88E-5 26 2.66E-4
13 SGTC_2690 usnic acid 3.45 100.0 µM 7.28E-5 48 2.79E-4
14 SGTC_2713 st079149 3.42 53.4 µM 8.50E-5 39 3.17E-4
15 SGTC_1701 st028638 3.31 40.4 µM 1.38E-4 33 4.75E-4
16 SGTC_749 1000-0129 3.29 128.0 µM 1.45E-4 amide catabolism 46 4.97E-4
17 SGTC_2837 9008476 3.14 45.5 µM 2.75E-4 69 8.49E-4
18 SGTC_1790 st045711 3.10 43.5 µM 3.20E-4 39 9.63E-4
19 SGTC_1170 0310-0127 3.06 64.8 µM 3.73E-4 67 0.00109
20 SGTC_2347 9049783 3.06 174.8 µM 3.75E-4 72 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.59E-45 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.241 1.88E-45 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.228 1.64E-40 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.219 1.83E-37 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.216 1.33E-36 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.215 1.70E-36 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.211 3.88E-35 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.207 1.04E-33 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.206 2.33E-33 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.204 5.23E-33 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.200 1.83E-31 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.198 6.04E-31 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.194 1.22E-29 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.193 1.41E-29 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.187 8.29E-28 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress