HIPHOP chemogenomics database

YDR117C / TMA64

Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR117C / TMA64

Click on Significant Values for Screen Details

Top fitness defect scores for YDR117C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2319	6033012	6.38	152.6 µM	1.16E-12	tubulin folding & SWR complex	12	8.90E-11
2	SGTC_514	4466-0038	4.93	2.6 nM	2.91E-8	cell wall	109	4.06E-7
3	SGTC_928	2764-0428	4.25	58.7 µM	1.48E-6	cell wall	50	1.08E-5
4	SGTC_3217	9129673	4.16	49.5 µM	2.40E-6		33	1.61E-5
5	SGTC_674	0498-0004	4.13	451.0 µM	2.72E-6	heme requiring	22	1.79E-5
6	SGTC_925	2064-1272	4.07	59.6 µM	3.85E-6		21	2.39E-5
7	SGTC_2703	st077852	3.96	53.4 µM	6.56E-6		24	3.73E-5
8	SGTC_2456	5770359	3.88	74.5 µM	9.72E-6		19	5.18E-5
9	SGTC_686	1319-0111	3.72	510.0 µM	2.17E-5	60S ribosome export	35	1.01E-4
10	SGTC_3265	9137266	3.64	49.5 µM	3.07E-5		14	1.35E-4
11	SGTC_676	falcarinol	3.57	140.0 µM	4.22E-5		68	1.77E-4
12	SGTC_2371	9071574	3.46	200.0 µM	6.88E-5		26	2.66E-4
13	SGTC_2690	usnic acid	3.45	100.0 µM	7.28E-5		48	2.79E-4
14	SGTC_2713	st079149	3.42	53.4 µM	8.50E-5		39	3.17E-4
15	SGTC_1701	st028638	3.31	40.4 µM	1.38E-4		33	4.75E-4
16	SGTC_749	1000-0129	3.29	128.0 µM	1.45E-4	amide catabolism	46	4.97E-4
17	SGTC_2837	9008476	3.14	45.5 µM	2.75E-4		69	8.49E-4
18	SGTC_1790	st045711	3.10	43.5 µM	3.20E-4		39	9.63E-4
19	SGTC_1170	0310-0127	3.06	64.8 µM	3.73E-4		67	0.00109
20	SGTC_2347	9049783	3.06	174.8 µM	3.75E-4		72	0.00110

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.241	1.59E-45	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.241	1.88E-45	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.228	1.64E-40	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.219	1.83E-37	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.216	1.33E-36	YDL222C	FMP45	hom	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.215	1.70E-36	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.211	3.88E-35	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.207	1.04E-33	YDL197C	ASF2	hom	Anti-silencing protein that causes derepression of silent loci when overexpressed
0.206	2.33E-33	YLR213C	CRR1	hom	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.204	5.23E-33	YOR301W	RAX1	hom	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.200	1.83E-31	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.198	6.04E-31	YDL176W	YDL176W	hom	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.194	1.22E-29	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.193	1.41E-29	YBR274W	CHK1	hom	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.187	8.29E-28	YDR169C	STB3	hom	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress