HIPHOP chemogenomics database
YDR119W_p / VBA4 
Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR119W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.160 | 1.09E-20 | YJL050W | MTR4 | het | ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing |
| 0.149 | 4.50E-18 | YBR165W | UBS1 | hom | Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity |
| 0.145 | 3.27E-17 | YJR084W | YJR084W | hom | Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome |
| 0.128 | 1.24E-13 | YER060W-A | FCY22 | hom | Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function |
| 0.120 | 2.74E-12 | YOL071W | EMI5 | hom | Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) |
| 0.120 | 3.03E-12 | YGR123C | PPT1 | hom | Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth |
| 0.116 | 1.87E-11 | YEL010W_d | YEL010W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.110 | 2.13E-10 | YBR186W | PCH2 | hom | Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation |
| 0.109 | 2.25E-10 | YGL081W_p | YGL081W_p | hom | Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis |
| 0.105 | 1.30E-9 | YBR191W | RPL21A | hom | Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication |
| 0.102 | 3.49E-9 | YIR016W_p | YIR016W_p | hom | Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication |
| 0.098 | 1.15E-8 | YBL017C | PEP1 | hom | Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments |
| 0.096 | 2.68E-8 | YML119W_p | YML119W_p | hom | Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate |
| 0.096 | 2.90E-8 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.095 | 3.30E-8 | YER053C | PIC2 | hom | Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature |