YDR122W / KIN1

Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR122W / KIN1

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-4.31|P-value:2.60E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:3.00|P-value:5.96E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.27|P-value:2.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.42|P-value:9.58E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.05|P-value:6.44E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.81|P-value:2.05E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:2.88|P-value:9.11E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.81|P-value:1.16E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:4.88|P-value:7.58E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.40|P-value:1.69E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.53|P-value:5.42E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-9.79|P-value:1.22E-25 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.79|P-value:2.21E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.07|P-value:4.60E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.31|P-value:2.36E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.50|P-value:7.83E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.34|P-value:1.54E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.84|P-value:2.48E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.20|P-value:2.72E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-2.94|P-value:9.92E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.08|P-value:4.39E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-2.94|P-value:9.63E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.95|P-value:1.49E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.02|P-value:7.22E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.15|P-value:3.32E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.29|P-value:1.91E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-2.95|P-value:9.58E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.01|P-value:7.54E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-2.95|P-value:9.29E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.08|P-value:4.30E-4 ID:SGTC_2303|Compound:7774051|FD-Score:2.95|P-value:7.27E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.21|P-value:2.87E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.49|P-value:8.24E-5 ID:SGTC_2390|Compound:9097792|FD-Score:-2.99|P-value:8.20E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.64|P-value:3.00E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.03|P-value:5.25E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.22|P-value:3.96E-6 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.65|P-value:5.75E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.05|P-value:4.93E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.85|P-value:1.63E-5 ID:SGTC_2898|Compound:9056270|FD-Score:4.29|P-value:1.94E-6 ID:SGTC_2899|Compound:9053889|FD-Score:3.30|P-value:1.86E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.52|P-value:7.38E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.62|P-value:4.78E-5 ID:SGTC_3292|Compound:9120825|FD-Score:4.44|P-value:8.64E-7 ID:SGTC_3293|Compound:9120939|FD-Score:3.69|P-value:3.44E-5 ID:SGTC_3297|Compound:9117502|FD-Score:6.11|P-value:2.68E-11 ID:SGTC_3313|Compound:9133968|FD-Score:2.99|P-value:6.24E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.31|P-value:2.60E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:3.00|P-value:5.96E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.27|P-value:2.09E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.42|P-value:9.58E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.05|P-value:6.44E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.81|P-value:2.05E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:2.88|P-value:9.11E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.81|P-value:1.16E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:4.88|P-value:7.58E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.40|P-value:1.69E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.53|P-value:5.42E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-9.79|P-value:1.22E-25 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.79|P-value:2.21E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.07|P-value:4.60E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.31|P-value:2.36E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.50|P-value:7.83E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.34|P-value:1.54E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.84|P-value:2.48E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.20|P-value:2.72E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-2.94|P-value:9.92E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.08|P-value:4.39E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-2.94|P-value:9.63E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.95|P-value:1.49E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.02|P-value:7.22E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.15|P-value:3.32E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.29|P-value:1.91E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-2.95|P-value:9.58E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.01|P-value:7.54E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-2.95|P-value:9.29E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.08|P-value:4.30E-4 ID:SGTC_2303|Compound:7774051|FD-Score:2.95|P-value:7.27E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.21|P-value:2.87E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.49|P-value:8.24E-5 ID:SGTC_2390|Compound:9097792|FD-Score:-2.99|P-value:8.20E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.64|P-value:3.00E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.03|P-value:5.25E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.22|P-value:3.96E-6 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.65|P-value:5.75E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.05|P-value:4.93E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.85|P-value:1.63E-5 ID:SGTC_2898|Compound:9056270|FD-Score:4.29|P-value:1.94E-6 ID:SGTC_2899|Compound:9053889|FD-Score:3.30|P-value:1.86E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.52|P-value:7.38E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.62|P-value:4.78E-5 ID:SGTC_3292|Compound:9120825|FD-Score:4.44|P-value:8.64E-7 ID:SGTC_3293|Compound:9120939|FD-Score:3.69|P-value:3.44E-5 ID:SGTC_3297|Compound:9117502|FD-Score:6.11|P-value:2.68E-11 ID:SGTC_3313|Compound:9133968|FD-Score:2.99|P-value:6.24E-4

Top fitness defect scores for YDR122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3297 9117502 6.11 71.4 µM 2.68E-11 3 5.00E-10
2 SGTC_886 0866-0150 4.88 153.0 µM 7.58E-8 5 5.25E-7
3 SGTC_669 0108-0021 4.81 26.2 µM 1.16E-7 fatty acid desaturase (OLE1) 42 7.62E-7
4 SGTC_2514 salinomycin 4.64 42.7 µM 3.00E-7 27 1.75E-6
5 SGTC_1008 4106-0037 4.53 6.0 µM 5.42E-7 PDR1 12 2.94E-6
6 SGTC_3292 9120825 4.44 59.8 µM 8.64E-7 9 4.42E-6
7 SGTC_310 1273-0058 4.42 1.1 µM 9.58E-7 mitochondrial stress 215 4.84E-6
8 SGTC_2103 5378138 4.29 10.0 µM 1.91E-6 7 8.86E-6
9 SGTC_2898 9056270 4.29 58.4 µM 1.94E-6 5 8.99E-6
10 SGTC_2316 5844804 4.21 197.4 µM 2.87E-6 22 1.27E-5
11 SGTC_2693 st077581 3.85 40.7 µM 1.63E-5 37 5.79E-5
12 SGTC_649 1123-0311 3.81 367.0 µM 2.05E-5 endomembrane recycling 77 7.09E-5
13 SGTC_1118 chelidonine 3.79 707.5 nM 2.21E-5 19 7.55E-5
14 SGTC_3293 9120939 3.69 62.0 µM 3.44E-5 25 1.11E-4
15 SGTC_3287 9117173 3.62 37.1 µM 4.78E-5 60S ribosome export 7 1.49E-4
16 SGTC_3284 9108171 3.52 64.9 µM 7.38E-5 36 2.17E-4
17 SGTC_1251 0490-5699 3.50 265.0 µM 7.83E-5 52 2.29E-4
18 SGTC_2322 7413319 3.49 38.2 µM 8.24E-5 ERAD & cell cycle 189 2.39E-4
19 SGTC_656 4090-1979 3.43 187.0 µM 1.07E-4 36 3.00E-4
20 SGTC_1279 0874-0590 3.34 65.2 µM 1.54E-4 52 4.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.295 2.93E-68 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.294 9.08E-68 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.285 5.81E-64 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.269 1.58E-56 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.265 3.52E-55 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.262 8.22E-54 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.259 1.29E-52 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.258 3.06E-52 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.256 1.89E-51 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.251 2.63E-49 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.243 2.55E-46 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.235 1.61E-43 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.222 9.16E-39 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.218 2.53E-37 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.217 5.84E-37 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p