HIPHOP chemogenomics database

YDR130C / FIN1

Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR130C / FIN1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR130C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1748	st037455	5.98	53.6 µM	3.23E-10		4	1.11E-9
2	SGTC_1780	st038448	5.85	24.5 µM	7.44E-10	iron homeostasis	2	2.42E-9
3	SGTC_1115	galangin	4.34	695.7 nM	3.79E-6	RPP1 & pyrimidine depletion	6	7.02E-6
4	SGTC_1632	st005650	4.04	90.0 µM	1.61E-5		28	2.72E-5
5	SGTC_967	1306-0166	3.95	352.0 µM	2.42E-5		34	3.98E-5
6	SGTC_1552	6-methylflavone	3.92	10.6 µM	2.73E-5	superoxide	16	4.45E-5
7	SGTC_2437	5741531	3.91	144.2 µM	2.81E-5		37	4.58E-5
8	SGTC_1979	st071809	3.86	45.3 µM	3.49E-5	RPP1 & pyrimidine depletion	15	5.62E-5
9	SGTC_2447	5741742	3.83	33.8 µM	4.00E-5		24	6.38E-5
10	SGTC_1940	st075990	3.57	51.1 µM	1.20E-4	60S ribosome export	31	1.79E-4
11	SGTC_1088	bifonazole	3.53	369.0 nM	1.42E-4		25	2.09E-4
12	SGTC_1625	st003711	3.52	30.1 µM	1.49E-4	calcium & mitochondrial duress	53	2.18E-4
13	SGTC_272	doxorubicin	3.47	8.1 µM	1.81E-4	anthracycline transcription coupled DNA repair	37	2.62E-4
14	SGTC_2282	7944268	3.43	200.0 µM	2.11E-4	RPP1 & pyrimidine depletion	55	3.04E-4
15	SGTC_1087	pterostilbene	3.40	9.1 µM	2.33E-4		50	3.33E-4
16	SGTC_2415	st077333	3.29	57.7 µM	3.58E-4		87	4.99E-4
17	SGTC_2519	cryptotanshinone	3.27	88.0 µM	3.91E-4	heme biosynthesis & mitochondrial translocase	33	5.41E-4
18	SGTC_1084	voriconazole	3.21	435.0 nM	4.82E-4	azole & statin	51	6.59E-4
19	SGTC_1672	st016598	3.20	6.5 µM	4.96E-4	endomembrane recycling	107	6.77E-4
20	SGTC_1360	1598-0022	3.18	39.8 µM	5.47E-4	ERG2	73	7.41E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.101	4.59E-9	YDR209C_d	YDR209C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.099	8.86E-9	YOR280C	FSH3	hom	Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
0.091	1.23E-7	YMR122C_d	YMR122C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090	1.71E-7	YGL245W	GUS1	het	Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.089	2.79E-7	YKL086W	SRX1	hom	Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress
0.088	2.95E-7	YDR003W	RCR2	hom	Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.088	3.70E-7	YEL058W	PCM1	het	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.087	4.68E-7	YLR104W_p	LCL2_p	hom	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.086	6.58E-7	YOR127W	RGA1	hom	GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.085	9.36E-7	YIL143C	SSL2	het	Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.084	1.12E-6	YJR116W_p	TDA4_p	hom	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.083	1.32E-6	YLR272C	YCS4	het	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.083	1.62E-6	YOR059C	YOR059C	hom	Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.080	3.28E-6	YMR119W-A_d	YMR119W-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079	5.03E-6	YDR124W_p	YDR124W_p	hom	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor