YDR130C / FIN1

Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR130C / FIN1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-4.45|P-value:1.56E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.12|P-value:6.75E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.47|P-value:1.81E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.48|P-value:1.29E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-5.09|P-value:4.99E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:3.04|P-value:8.91E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.08|P-value:7.70E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:-2.96|P-value:9.18E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.95|P-value:2.42E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-4.90|P-value:1.46E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.21|P-value:3.71E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.13|P-value:6.40E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.05|P-value:6.61E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.21|P-value:4.82E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.40|P-value:2.33E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.85|P-value:2.65E-5 ID:SGTC_1115|Compound:galangin|FD-Score:4.34|P-value:3.79E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.23|P-value:3.40E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.15|P-value:6.14E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.18|P-value:5.47E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.22|P-value:3.56E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.92|P-value:2.73E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.06|P-value:6.45E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.52|P-value:1.49E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.04|P-value:1.61E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.20|P-value:4.96E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-5.13|P-value:3.86E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-3.62|P-value:7.14E-5 ID:SGTC_1748|Compound:st037455|FD-Score:5.98|P-value:3.23E-10 ID:SGTC_1780|Compound:st038448|FD-Score:5.85|P-value:7.44E-10 ID:SGTC_1919|Compound:st067113|FD-Score:-7.05|P-value:9.00E-14 ID:SGTC_1940|Compound:st075990|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.86|P-value:2.59E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.08|P-value:7.73E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.63|P-value:7.00E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.86|P-value:3.49E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.35|P-value:2.58E-6 ID:SGTC_2282|Compound:7944268|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.29|P-value:3.58E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.91|P-value:2.81E-5 ID:SGTC_2442|Compound:5158906|FD-Score:-3.02|P-value:7.50E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-4.10|P-value:8.33E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.27|P-value:3.91E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.14|P-value:6.37E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.18|P-value:4.18E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.06|P-value:8.48E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.45|P-value:1.56E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.12|P-value:6.75E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.47|P-value:1.81E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.48|P-value:1.29E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-5.09|P-value:4.99E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:3.04|P-value:8.91E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.08|P-value:7.70E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:-2.96|P-value:9.18E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.95|P-value:2.42E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-4.90|P-value:1.46E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.21|P-value:3.71E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.13|P-value:6.40E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.05|P-value:6.61E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.21|P-value:4.82E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.40|P-value:2.33E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.85|P-value:2.65E-5 ID:SGTC_1115|Compound:galangin|FD-Score:4.34|P-value:3.79E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.23|P-value:3.40E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.15|P-value:6.14E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.18|P-value:5.47E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.22|P-value:3.56E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.92|P-value:2.73E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.06|P-value:6.45E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.52|P-value:1.49E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.04|P-value:1.61E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.20|P-value:4.96E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-5.13|P-value:3.86E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-3.62|P-value:7.14E-5 ID:SGTC_1748|Compound:st037455|FD-Score:5.98|P-value:3.23E-10 ID:SGTC_1780|Compound:st038448|FD-Score:5.85|P-value:7.44E-10 ID:SGTC_1919|Compound:st067113|FD-Score:-7.05|P-value:9.00E-14 ID:SGTC_1940|Compound:st075990|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.86|P-value:2.59E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.08|P-value:7.73E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.63|P-value:7.00E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.86|P-value:3.49E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.35|P-value:2.58E-6 ID:SGTC_2282|Compound:7944268|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.29|P-value:3.58E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.91|P-value:2.81E-5 ID:SGTC_2442|Compound:5158906|FD-Score:-3.02|P-value:7.50E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-4.10|P-value:8.33E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.27|P-value:3.91E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.14|P-value:6.37E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.18|P-value:4.18E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.06|P-value:8.48E-4

Top fitness defect scores for YDR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1748 st037455 5.98 53.6 µM 3.23E-10 4 1.11E-9
2 SGTC_1780 st038448 5.85 24.5 µM 7.44E-10 iron homeostasis 2 2.42E-9
3 SGTC_1115 galangin 4.34 695.7 nM 3.79E-6 RPP1 & pyrimidine depletion 6 7.02E-6
4 SGTC_1632 st005650 4.04 90.0 µM 1.61E-5 28 2.72E-5
5 SGTC_967 1306-0166 3.95 352.0 µM 2.42E-5 34 3.98E-5
6 SGTC_1552 6-methylflavone 3.92 10.6 µM 2.73E-5 superoxide 16 4.45E-5
7 SGTC_2437 5741531 3.91 144.2 µM 2.81E-5 37 4.58E-5
8 SGTC_1979 st071809 3.86 45.3 µM 3.49E-5 RPP1 & pyrimidine depletion 15 5.62E-5
9 SGTC_2447 5741742 3.83 33.8 µM 4.00E-5 24 6.38E-5
10 SGTC_1940 st075990 3.57 51.1 µM 1.20E-4 60S ribosome export 31 1.79E-4
11 SGTC_1088 bifonazole 3.53 369.0 nM 1.42E-4 25 2.09E-4
12 SGTC_1625 st003711 3.52 30.1 µM 1.49E-4 calcium & mitochondrial duress 53 2.18E-4
13 SGTC_272 doxorubicin 3.47 8.1 µM 1.81E-4 anthracycline transcription coupled DNA repair 37 2.62E-4
14 SGTC_2282 7944268 3.43 200.0 µM 2.11E-4 RPP1 & pyrimidine depletion 55 3.04E-4
15 SGTC_1087 pterostilbene 3.40 9.1 µM 2.33E-4 50 3.33E-4
16 SGTC_2415 st077333 3.29 57.7 µM 3.58E-4 87 4.99E-4
17 SGTC_2519 cryptotanshinone 3.27 88.0 µM 3.91E-4 heme biosynthesis & mitochondrial translocase 33 5.41E-4
18 SGTC_1084 voriconazole 3.21 435.0 nM 4.82E-4 azole & statin 51 6.59E-4
19 SGTC_1672 st016598 3.20 6.5 µM 4.96E-4 endomembrane recycling 107 6.77E-4
20 SGTC_1360 1598-0022 3.18 39.8 µM 5.47E-4 ERG2 73 7.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.59E-9 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.099 8.86E-9 YOR280C FSH3 hom Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
0.091 1.23E-7 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.71E-7 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.089 2.79E-7 YKL086W SRX1 hom Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress
0.088 2.95E-7 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.088 3.70E-7 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.087 4.68E-7 YLR104W_p LCL2_p hom Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.086 6.58E-7 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.085 9.36E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.084 1.12E-6 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.083 1.32E-6 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.083 1.62E-6 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.080 3.28E-6 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 5.03E-6 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor