YDR133C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR133C / YDR133C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.77|P-value:1.37E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.94|P-value:5.53E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.11|P-value:2.30E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.51|P-value:4.59E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.96|P-value:4.85E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.92|P-value:5.65E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.03|P-value:3.61E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:2.86|P-value:7.53E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.12|P-value:2.58E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:2.99|P-value:4.36E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.53|P-value:4.24E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:-2.87|P-value:6.86E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.28|P-value:1.25E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:2.89|P-value:6.59E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.75|P-value:6.41E-8 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.25|P-value:1.49E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.63|P-value:2.55E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.48|P-value:5.06E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.42|P-value:4.14E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.02|P-value:3.72E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.56|P-value:3.70E-5 ID:SGTC_1758|Compound:st042942|FD-Score:2.81|P-value:8.83E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.97|P-value:4.81E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.40|P-value:4.93E-7 ID:SGTC_2014|Compound:4013930|FD-Score:3.68|P-value:2.11E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.12|P-value:2.65E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.30|P-value:1.17E-4 ID:SGTC_2372|Compound:9071633|FD-Score:2.91|P-value:6.09E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.91|P-value:5.85E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.97|P-value:4.83E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.85|P-value:7.76E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.94|P-value:5.48E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.98|P-value:4.60E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.83|P-value:8.38E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:2.93|P-value:5.59E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.27|P-value:1.37E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.84|P-value:7.70E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.83|P-value:8.00E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.80|P-value:9.30E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.09|P-value:3.02E-4 ID:SGTC_2709|Compound:st078560|FD-Score:2.95|P-value:5.14E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.83|P-value:1.04E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.54|P-value:3.95E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.27|P-value:1.31E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.85|P-value:7.35E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.13|P-value:2.39E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-2.78|P-value:9.40E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.83|P-value:3.63E-8 ID:SGTC_2939|Compound:9044578|FD-Score:-2.79|P-value:9.03E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.36|P-value:8.94E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.38|P-value:8.42E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.12|P-value:2.44E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.82|P-value:8.23E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-2.78|P-value:9.50E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.77|P-value:1.37E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.94|P-value:5.53E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.11|P-value:2.30E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.51|P-value:4.59E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.96|P-value:4.85E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.92|P-value:5.65E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.03|P-value:3.61E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:2.86|P-value:7.53E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.12|P-value:2.58E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:2.99|P-value:4.36E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.53|P-value:4.24E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:-2.87|P-value:6.86E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.28|P-value:1.25E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:2.89|P-value:6.59E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.75|P-value:6.41E-8 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.25|P-value:1.49E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.63|P-value:2.55E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.48|P-value:5.06E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.42|P-value:4.14E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.02|P-value:3.72E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.56|P-value:3.70E-5 ID:SGTC_1758|Compound:st042942|FD-Score:2.81|P-value:8.83E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.97|P-value:4.81E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.40|P-value:4.93E-7 ID:SGTC_2014|Compound:4013930|FD-Score:3.68|P-value:2.11E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.12|P-value:2.65E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.30|P-value:1.17E-4 ID:SGTC_2372|Compound:9071633|FD-Score:2.91|P-value:6.09E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.91|P-value:5.85E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.97|P-value:4.83E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.85|P-value:7.76E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.94|P-value:5.48E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.98|P-value:4.60E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.83|P-value:8.38E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:2.93|P-value:5.59E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.27|P-value:1.37E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.84|P-value:7.70E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.83|P-value:8.00E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.80|P-value:9.30E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.09|P-value:3.02E-4 ID:SGTC_2709|Compound:st078560|FD-Score:2.95|P-value:5.14E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.83|P-value:1.04E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.54|P-value:3.95E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.27|P-value:1.31E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.85|P-value:7.35E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.13|P-value:2.39E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-2.78|P-value:9.40E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.83|P-value:3.63E-8 ID:SGTC_2939|Compound:9044578|FD-Score:-2.79|P-value:9.03E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.36|P-value:8.94E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.38|P-value:8.42E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.12|P-value:2.44E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.82|P-value:8.23E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-2.78|P-value:9.50E-4

Top fitness defect scores for YDR133C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1271 0832-2808 4.75 169.0 µM 6.41E-8 3 1.03E-6
2 SGTC_2002 4023503 4.40 131.0 µM 4.93E-7 mitochondrial processes 21 5.42E-6
3 SGTC_2724 maprotiline 3.83 69.6 µM 1.04E-5 ERG2 18 6.50E-5
4 SGTC_65 0798-0905 3.77 35.0 µM 1.37E-5 calcium & mitochondrial duress 96 8.14E-5
5 SGTC_2014 4013930 3.68 200.0 µM 2.11E-5 49 1.16E-4
6 SGTC_1751 st044839 3.56 27.2 µM 3.70E-5 Golgi 15 1.83E-4
7 SGTC_810 3825-7150 3.53 143.0 µM 4.24E-5 60S ribosome export 14 2.04E-4
8 SGTC_2989 9073649 3.38 71.4 µM 8.42E-5 64 3.58E-4
9 SGTC_2605 digitonin 3.27 300.0 nM 1.37E-4 60 5.33E-4
10 SGTC_1282 0886-0010 3.25 32.4 µM 1.49E-4 endomembrane recycling 63 5.71E-4
11 SGTC_281 1672-3440 3.22 14.9 µM 1.70E-4 Golgi 21 6.36E-4
12 SGTC_549 1661-1316 3.12 519.0 µM 2.58E-4 51 8.93E-4
13 SGTC_2253 7938677 3.12 135.8 µM 2.65E-4 40 9.13E-4
14 SGTC_2704 st078022 3.09 71.1 µM 3.02E-4 39 0.00102
15 SGTC_701 4424-0219 2.99 185.0 µM 4.36E-4 calcium & mitochondrial duress 51 0.00137
16 SGTC_2536 dehydroabietamide 2.98 32.0 µM 4.60E-4 97 0.00144
17 SGTC_1811 st050069 2.97 61.5 µM 4.81E-4 21 0.00149
18 SGTC_2491 paeonol 2.97 100.0 µM 4.83E-4 28 0.00149
19 SGTC_2709 st078560 2.95 56.0 µM 5.14E-4 44 0.00157
20 SGTC_2493 resveratrol 2.94 26.1 µM 5.48E-4 39 0.00166

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.340 1.52E-91 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.328 7.39E-85 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.297 6.27E-69 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.263 4.10E-54 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.261 5.49E-53 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.257 1.06E-51 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.251 2.28E-49 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.250 5.83E-49 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.249 1.93E-48 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.247 6.82E-48 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.237 4.50E-44 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.236 1.95E-43 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.234 6.73E-43 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.232 5.85E-42 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.229 5.50E-41 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis