YDR134C

Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR134C / YDR134C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.93|P-value:1.14E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.06|P-value:4.94E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.98|P-value:6.41E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.23|P-value:2.44E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.17|P-value:3.13E-4 ID:SGTC_232|Compound:clozapine|FD-Score:2.96|P-value:7.12E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.32|P-value:1.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.12|P-value:3.78E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.02|P-value:5.73E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.84|P-value:1.67E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.01|P-value:5.68E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.48|P-value:8.83E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-4.07|P-value:5.65E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:2.90|P-value:9.07E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:2.91|P-value:8.69E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:5.18|P-value:1.23E-8 ID:SGTC_716|Compound:1683-5115|FD-Score:6.58|P-value:6.57E-13 ID:SGTC_731|Compound:3966-0296|FD-Score:3.52|P-value:7.66E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:-2.88|P-value:9.47E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.02|P-value:5.82E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.39|P-value:1.24E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.16|P-value:3.30E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.03|P-value:5.41E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.89|P-value:9.38E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.65|P-value:4.25E-5 ID:SGTC_1696|Compound:st025591|FD-Score:-2.91|P-value:8.23E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.37|P-value:1.44E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.55|P-value:6.72E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.81|P-value:2.10E-5 ID:SGTC_1910|Compound:st062352|FD-Score:2.95|P-value:7.47E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.18|P-value:2.99E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.93|P-value:8.22E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.87|P-value:1.44E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.12|P-value:3.80E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.72|P-value:3.14E-5 ID:SGTC_2398|Compound:5228213|FD-Score:2.92|P-value:8.43E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.08|P-value:5.23E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.25|P-value:2.27E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.97|P-value:7.00E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-2.92|P-value:8.16E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.03|P-value:5.62E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.93|P-value:1.14E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.06|P-value:4.94E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.98|P-value:6.41E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.23|P-value:2.44E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.17|P-value:3.13E-4 ID:SGTC_232|Compound:clozapine|FD-Score:2.96|P-value:7.12E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.32|P-value:1.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.12|P-value:3.78E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.02|P-value:5.73E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.84|P-value:1.67E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.01|P-value:5.68E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.48|P-value:8.83E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-4.07|P-value:5.65E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:2.90|P-value:9.07E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:2.91|P-value:8.69E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:5.18|P-value:1.23E-8 ID:SGTC_716|Compound:1683-5115|FD-Score:6.58|P-value:6.57E-13 ID:SGTC_731|Compound:3966-0296|FD-Score:3.52|P-value:7.66E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:-2.88|P-value:9.47E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.02|P-value:5.82E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.39|P-value:1.24E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.16|P-value:3.30E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.03|P-value:5.41E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.89|P-value:9.38E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.65|P-value:4.25E-5 ID:SGTC_1696|Compound:st025591|FD-Score:-2.91|P-value:8.23E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.37|P-value:1.44E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.55|P-value:6.72E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.81|P-value:2.10E-5 ID:SGTC_1910|Compound:st062352|FD-Score:2.95|P-value:7.47E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.18|P-value:2.99E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.93|P-value:8.22E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.87|P-value:1.44E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.12|P-value:3.80E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.72|P-value:3.14E-5 ID:SGTC_2398|Compound:5228213|FD-Score:2.92|P-value:8.43E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.08|P-value:5.23E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.25|P-value:2.27E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.97|P-value:7.00E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-2.92|P-value:8.16E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.03|P-value:5.62E-4

Top fitness defect scores for YDR134C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_716 1683-5115 6.58 658.0 µM 6.57E-13 2 2.28E-11
2 SGTC_713 1488-1073 5.18 324.0 µM 1.23E-8 ERG2 9 1.12E-7
3 SGTC_50 0929-0078 3.93 56.4 µM 1.14E-5 47 4.19E-5
4 SGTC_1909 st060837 3.81 51.5 µM 2.10E-5 59 7.07E-5
5 SGTC_2310 7668677 3.72 200.0 µM 3.14E-5 40 1.00E-4
6 SGTC_1685 st024049 3.65 53.1 µM 4.25E-5 TSC3-RPN4 18 1.31E-4
7 SGTC_1836 st055642 3.55 81.0 µM 6.72E-5 31 1.95E-4
8 SGTC_731 3966-0296 3.52 387.0 µM 7.66E-5 26 2.18E-4
9 SGTC_425 3825-7017 3.48 13.1 µM 8.83E-5 38 2.47E-4
10 SGTC_1790 st045711 3.37 43.5 µM 1.44E-4 28 3.76E-4
11 SGTC_234 nsc-17383 3.32 10.7 µM 1.78E-4 ERG2 36 4.54E-4
12 SGTC_1394 3474-0001 3.16 65.7 µM 3.30E-4 endomembrane recycling 70 7.77E-4
13 SGTC_75 0159-0059 3.06 199.0 µM 4.94E-4 fatty acid desaturase (OLE1) 58 0.00110
14 SGTC_2799 7812892 3.03 81.8 µM 5.62E-4 superoxide 66 0.00123
15 SGTC_243 5hr heat shock (37°C) + splitomicin 3.02 1.0 µM 5.73E-4 heat shock/prefoldin 104 0.00126
16 SGTC_907 3448-6986 3.02 75.5 µM 5.82E-4 64 0.00127
17 SGTC_2625 euphol 2.97 100.0 µM 7.00E-4 85 0.00150
18 SGTC_232 clozapine 2.96 119.0 µM 7.12E-4 NEO1 115 0.00152
19 SGTC_1910 st062352 2.95 60.4 µM 7.47E-4 83 0.00158
20 SGTC_2045 5106652 2.93 78.0 µM 8.22E-4 52 0.00172

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.10E-28 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.142 1.38E-16 YEL010W_d YEL010W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 4.39E-15 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.127 1.33E-13 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.114 3.50E-11 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
0.104 1.39E-9 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.103 2.36E-9 YKL031W_d YKL031W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.101 3.99E-9 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.101 4.62E-9 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.85E-9 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.097 1.80E-8 YBR030W RKM3 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein
0.093 7.08E-8 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.092 8.10E-8 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.086 5.29E-7 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.086 6.10E-7 YFL053W DAK2 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation