YDR140W / MTQ2

S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR140W / MTQ2

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.33|P-value:3.11E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.76|P-value:5.77E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:7.11|P-value:1.73E-13 ID:SGTC_71|Compound:0417-1750|FD-Score:5.59|P-value:5.37E-9 ID:SGTC_78|Compound:0336-0123|FD-Score:3.44|P-value:2.11E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.47|P-value:2.35E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.78|P-value:5.39E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:4.94|P-value:2.05E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:10.20|P-value:1.26E-25 ID:SGTC_132|Compound:0417-1715|FD-Score:4.80|P-value:4.42E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:3.81|P-value:4.67E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:5.43|P-value:1.35E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.14|P-value:7.36E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.12|P-value:7.80E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.02|P-value:9.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.14|P-value:1.34E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.10|P-value:1.14E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:5.46|P-value:1.14E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.12|P-value:2.58E-10 ID:SGTC_422|Compound:cantharidin|FD-Score:4.71|P-value:6.84E-7 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.71|P-value:8.57E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.32|P-value:3.34E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:9.46|P-value:2.02E-22 ID:SGTC_625|Compound:k213-0058|FD-Score:5.21|P-value:4.71E-8 ID:SGTC_655|Compound:k060-0012|FD-Score:4.82|P-value:3.97E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:4.85|P-value:3.41E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:7.78|P-value:8.64E-16 ID:SGTC_830|Compound:4076-0286|FD-Score:7.27|P-value:5.33E-14 ID:SGTC_831|Compound:k061-1017|FD-Score:5.78|P-value:1.59E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:8.99|P-value:1.89E-20 ID:SGTC_877|Compound:0771-0151|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.13|P-value:7.55E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.07|P-value:9.46E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.12|P-value:6.66E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.51|P-value:1.89E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.03|P-value:9.13E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.92|P-value:2.34E-7 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.83|P-value:3.79E-7 ID:SGTC_1608|Compound:st001473|FD-Score:-3.10|P-value:8.36E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.85|P-value:3.30E-7 ID:SGTC_1624|Compound:st003710|FD-Score:5.22|P-value:4.45E-8 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.49|P-value:2.04E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.44|P-value:2.09E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:6.95E-5 ID:SGTC_1769|Compound:st044406|FD-Score:4.52|P-value:1.82E-6 ID:SGTC_1774|Compound:st048371|FD-Score:-4.02|P-value:2.28E-5 ID:SGTC_1781|Compound:st038725|FD-Score:3.82|P-value:4.42E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-4.35|P-value:5.19E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-4.01|P-value:2.41E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.29|P-value:4.25E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.56|P-value:1.88E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.83|P-value:4.25E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.46|P-value:1.95E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.55|P-value:1.62E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.07|P-value:7.99E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.69|P-value:9.08E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.40|P-value:2.82E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.75|P-value:7.18E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.87|P-value:3.06E-7 ID:SGTC_2736|Compound:butenafine|FD-Score:3.05|P-value:8.63E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.07|P-value:9.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.11|P-value:2.63E-10 ID:SGTC_2909|Compound:7941780|FD-Score:4.57|P-value:1.45E-6 ID:SGTC_2964|Compound:9083345|FD-Score:3.12|P-value:6.84E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.11|P-value:8.17E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.62|P-value:1.09E-6 ID:SGTC_2988|Compound:9073640|FD-Score:-3.42|P-value:2.63E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.04|P-value:1.74E-5 ID:SGTC_3275|Compound:9138069|FD-Score:6.00|P-value:4.04E-10 ID:SGTC_3278|Compound:9139605|FD-Score:3.89|P-value:3.25E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.33|P-value:4.49E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.33|P-value:3.11E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.76|P-value:5.77E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:7.11|P-value:1.73E-13 ID:SGTC_71|Compound:0417-1750|FD-Score:5.59|P-value:5.37E-9 ID:SGTC_78|Compound:0336-0123|FD-Score:3.44|P-value:2.11E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.47|P-value:2.35E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.78|P-value:5.39E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:4.94|P-value:2.05E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:10.20|P-value:1.26E-25 ID:SGTC_132|Compound:0417-1715|FD-Score:4.80|P-value:4.42E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:3.81|P-value:4.67E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:5.43|P-value:1.35E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.14|P-value:7.36E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.12|P-value:7.80E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.02|P-value:9.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.14|P-value:1.34E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.10|P-value:1.14E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:5.46|P-value:1.14E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.12|P-value:2.58E-10 ID:SGTC_422|Compound:cantharidin|FD-Score:4.71|P-value:6.84E-7 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.71|P-value:8.57E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.32|P-value:3.34E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:9.46|P-value:2.02E-22 ID:SGTC_625|Compound:k213-0058|FD-Score:5.21|P-value:4.71E-8 ID:SGTC_655|Compound:k060-0012|FD-Score:4.82|P-value:3.97E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:4.85|P-value:3.41E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:7.78|P-value:8.64E-16 ID:SGTC_830|Compound:4076-0286|FD-Score:7.27|P-value:5.33E-14 ID:SGTC_831|Compound:k061-1017|FD-Score:5.78|P-value:1.59E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:8.99|P-value:1.89E-20 ID:SGTC_877|Compound:0771-0151|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.13|P-value:7.55E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.07|P-value:9.46E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.12|P-value:6.66E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.51|P-value:1.89E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.03|P-value:9.13E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.92|P-value:2.34E-7 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.83|P-value:3.79E-7 ID:SGTC_1608|Compound:st001473|FD-Score:-3.10|P-value:8.36E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.85|P-value:3.30E-7 ID:SGTC_1624|Compound:st003710|FD-Score:5.22|P-value:4.45E-8 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.49|P-value:2.04E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.44|P-value:2.09E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:6.95E-5 ID:SGTC_1769|Compound:st044406|FD-Score:4.52|P-value:1.82E-6 ID:SGTC_1774|Compound:st048371|FD-Score:-4.02|P-value:2.28E-5 ID:SGTC_1781|Compound:st038725|FD-Score:3.82|P-value:4.42E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-4.35|P-value:5.19E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-4.01|P-value:2.41E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.29|P-value:4.25E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.56|P-value:1.88E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.83|P-value:4.25E-5 ID:SGTC_2156|Compound:5649887|FD-Score:3.46|P-value:1.95E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.55|P-value:1.62E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.07|P-value:7.99E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.69|P-value:9.08E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.40|P-value:2.82E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.75|P-value:7.18E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.87|P-value:3.06E-7 ID:SGTC_2736|Compound:butenafine|FD-Score:3.05|P-value:8.63E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.07|P-value:9.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.11|P-value:2.63E-10 ID:SGTC_2909|Compound:7941780|FD-Score:4.57|P-value:1.45E-6 ID:SGTC_2964|Compound:9083345|FD-Score:3.12|P-value:6.84E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.11|P-value:8.17E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.62|P-value:1.09E-6 ID:SGTC_2988|Compound:9073640|FD-Score:-3.42|P-value:2.63E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.04|P-value:1.74E-5 ID:SGTC_3275|Compound:9138069|FD-Score:6.00|P-value:4.04E-10 ID:SGTC_3278|Compound:9139605|FD-Score:3.89|P-value:3.25E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.33|P-value:4.49E-6

Top fitness defect scores for YDR140W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_130 0136-0219 10.20 337.7 µM 1.26E-25 1 1.28E-24
2 SGTC_582 0987-0078 9.46 156.0 µM 2.02E-22 calcium & mitochondrial duress 10 1.53E-21
3 SGTC_832 4083-0019 8.99 164.0 µM 1.89E-20 translation 4 1.20E-19
4 SGTC_800 3448-7362 7.78 155.0 µM 8.64E-16 translation 17 3.54E-15
5 SGTC_830 4076-0286 7.27 57.8 µM 5.33E-14 translation 5 1.85E-13
6 SGTC_65 0798-0905 7.11 35.0 µM 1.73E-13 calcium & mitochondrial duress 19 5.71E-13
7 SGTC_3275 9138069 6.00 49.5 µM 4.04E-10 1 9.73E-10
8 SGTC_831 k061-1017 5.78 217.0 µM 1.59E-9 translation 12 3.63E-9
9 SGTC_71 0417-1750 5.59 47.8 µM 5.37E-9 Golgi 18 1.16E-8
10 SGTC_309 k408-0051 5.46 1.5 µM 1.14E-8 16 2.40E-8
11 SGTC_140 0062-0056 5.43 502.5 µM 1.35E-8 6 2.81E-8
12 SGTC_1624 st003710 5.22 6.2 µM 4.45E-8 calcium & mitochondrial duress 20 8.85E-8
13 SGTC_625 k213-0058 5.21 121.0 µM 4.71E-8 translation 55 9.34E-8
14 SGTC_1103 duloxetine 5.13 36.1 µM 7.55E-8 8 1.47E-7
15 SGTC_129 0088-0017 4.94 176.6 µM 2.05E-7 48 3.83E-7
16 SGTC_1465 k213-0056 4.92 144.0 µM 2.34E-7 DNA intercalators 10 4.34E-7
17 SGTC_2688 kanamycin b 4.87 96.7 µM 3.06E-7 calcium & mitochondrial duress 255 5.61E-7
18 SGTC_1623 st003709 4.85 20.3 µM 3.30E-7 calcium & mitochondrial duress 36 6.04E-7
19 SGTC_708 3448-5400 4.85 146.0 µM 3.41E-7 20 6.23E-7
20 SGTC_1466 k213-0079 4.83 57.5 µM 3.79E-7 5 6.90E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 1.91E-99 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.246 1.57E-47 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.243 2.43E-46 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.219 1.33E-37 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.215 2.25E-36 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.208 4.58E-34 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.206 1.28E-33 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.202 2.87E-32 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.202 3.57E-32 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.193 2.39E-29 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.192 4.14E-29 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.191 6.37E-29 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.191 8.65E-29 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.186 1.82E-27 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.185 3.01E-27 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p