YDR143C / SAN1

Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR143C / SAN1

Click on Significant Values for Screen Details ID:SGTC_308|Compound:4092-1169|FD-Score:3.38|P-value:2.58E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.02|P-value:8.02E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-2.98|P-value:9.24E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.96|P-value:2.29E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.04|P-value:7.51E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.18|P-value:5.50E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.36|P-value:2.25E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.67|P-value:6.42E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.41|P-value:2.13E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.74|P-value:4.86E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.04|P-value:7.35E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.38|P-value:2.59E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-3.32|P-value:2.67E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.80|P-value:3.66E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.16|P-value:5.94E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.98|P-value:1.65E-5 ID:SGTC_2076|Compound:5212012|FD-Score:-2.97|P-value:9.44E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-4.14|P-value:8.06E-6 ID:SGTC_2121|Compound:5257820|FD-Score:-3.92|P-value:2.21E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-4.02|P-value:1.39E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.29|P-value:3.00E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.00|P-value:8.68E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.68|P-value:6.23E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.49|P-value:1.67E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.98|P-value:2.13E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.23|P-value:4.54E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-3.57|P-value:9.58E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.28|P-value:5.21E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-5.54|P-value:4.09E-9 ID:SGTC_3156|Compound:9099931|FD-Score:3.25|P-value:4.15E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_3226|Compound:9131256|FD-Score:-3.20|P-value:4.14E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.81|P-value:4.50E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-3.26|P-value:3.25E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.38|P-value:2.58E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.02|P-value:8.02E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-2.98|P-value:9.24E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.96|P-value:2.29E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.04|P-value:7.51E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.18|P-value:5.50E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.36|P-value:2.25E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.67|P-value:6.42E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.41|P-value:2.13E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.74|P-value:4.86E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.04|P-value:7.35E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.38|P-value:2.59E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-3.32|P-value:2.67E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.80|P-value:3.66E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.16|P-value:5.94E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.98|P-value:1.65E-5 ID:SGTC_2076|Compound:5212012|FD-Score:-2.97|P-value:9.44E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-4.14|P-value:8.06E-6 ID:SGTC_2121|Compound:5257820|FD-Score:-3.92|P-value:2.21E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-4.02|P-value:1.39E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.29|P-value:3.00E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.00|P-value:8.68E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.68|P-value:6.23E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.49|P-value:1.67E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.98|P-value:2.13E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.23|P-value:4.54E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.95|P-value:2.41E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-3.57|P-value:9.58E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.28|P-value:5.21E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-5.54|P-value:4.09E-9 ID:SGTC_3156|Compound:9099931|FD-Score:3.25|P-value:4.15E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_3226|Compound:9131256|FD-Score:-3.20|P-value:4.14E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.81|P-value:4.50E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-3.26|P-value:3.25E-4

Top fitness defect scores for YDR143C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2962 9082311 4.28 13.2 µM 5.21E-6 11 9.22E-6
2 SGTC_2762 leflunomide 3.98 42.1 µM 2.13E-5 27 3.47E-5
3 SGTC_1033 k072-0102 3.96 21.3 µM 2.29E-5 60S ribosome export 22 3.72E-5
4 SGTC_2894 9048625 3.95 32.5 µM 2.41E-5 10 3.90E-5
5 SGTC_3245 9134821 3.81 49.5 µM 4.50E-5 21 7.01E-5
6 SGTC_2758 dehydroepiandrosterone 3.49 69.3 µM 1.67E-4 57 2.42E-4
7 SGTC_308 4092-1169 3.38 104.0 µM 2.58E-4 plasma membrane duress 76 3.63E-4
8 SGTC_1747 st037496 3.38 66.6 µM 2.59E-4 34 3.65E-4
9 SGTC_3156 9099931 3.25 49.5 µM 4.15E-4 26 5.69E-4
10 SGTC_2858 9025781 3.23 9.0 µM 4.54E-4 sphingolipid biosynthesis & PDR1 146 6.20E-4
11 SGTC_1044 1222-0021 3.18 1.8 µM 5.50E-4 heme biosynthesis & mitochondrial translocase 70 7.42E-4
12 SGTC_3191 9110352 3.17 49.5 µM 5.66E-4 30 7.63E-4
13 SGTC_1944 st076371 3.16 56.9 µM 5.94E-4 48 7.98E-4
14 SGTC_1949 st076024 2.93 69.1 µM 0.00131 76 0.00168
15 SGTC_699 0375-0592 2.89 111.0 µM 0.00149 iron homeostasis 64 0.00190
16 SGTC_1347 1493-0251 2.77 600.0 nM 0.00222 mitochondrial response to ROS 75 0.00278
17 SGTC_3258 9138477 2.77 49.5 µM 0.00227 60 0.00283
18 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 2.72 92.6 µM 0.00261 93 0.00323
19 SGTC_1774 st048371 2.70 48.5 µM 0.00278 RNA processing & uracil transport 95 0.00343
20 SGTC_1782 st039423 2.68 80.6 µM 0.00297 103 0.00365

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.01E-22 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.154 2.51E-19 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.150 2.11E-18 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.142 1.20E-16 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.137 1.79E-15 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.136 2.92E-15 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.117 9.11E-12 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.116 1.63E-11 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.112 8.30E-11 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.109 2.86E-10 YNL083W SAL1 hom ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains
0.105 9.45E-10 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.100 6.29E-9 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.097 1.52E-8 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.097 2.10E-8 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.096 2.24E-8 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene