HIPHOP chemogenomics database

YDR146C / SWI5

Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR146C / SWI5

Click on Significant Values for Screen Details

Top fitness defect scores for YDR146C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2425	5628681	5.87	7.8 µM	5.99E-11		3	2.23E-9
2	SGTC_2581	avocatin a	5.44	64.0 µM	1.18E-9	sphingolipid biosynthesis & PDR1	28	2.68E-8
3	SGTC_2432	5630864	4.93	12.2 µM	3.05E-8		10	4.02E-7
4	SGTC_1491	4138-0063	4.58	26.5 µM	2.50E-7		4	2.32E-6
5	SGTC_1203	3992-3522	4.32	103.0 µM	1.05E-6		20	7.69E-6
6	SGTC_1748	st037455	4.32	53.6 µM	1.05E-6		20	7.70E-6
7	SGTC_1008	4106-0037	3.94	6.0 µM	7.62E-6	PDR1	20	4.02E-5
8	SGTC_70	0141-0289	3.80	43.3 µM	1.55E-5	mitochondrial stress	189	7.28E-5
9	SGTC_1744	st037937	3.75	38.9 µM	1.99E-5		35	8.97E-5
10	SGTC_2303	7774051	3.71	200.0 µM	2.42E-5		27	1.06E-4
11	SGTC_213	1246-0773	3.67	967.0 nM	2.86E-5		30	1.22E-4
12	SGTC_1455	4262-0120	3.52	131.0 µM	5.79E-5	plasma membrane duress	36	2.20E-4
13	SGTC_1743	st037606	3.49	46.4 µM	6.43E-5		35	2.40E-4
14	SGTC_734	2023-0417	3.46	80.0 µM	7.31E-5	ergosterol biosynthesis	32	2.67E-4
15	SGTC_1785	bathophenanthroline	3.40	24.0 µM	9.69E-5	heme requiring	77	3.38E-4
16	SGTC_415	dibenzyl ketone	3.39	100.0 µM	1.02E-4		26	3.52E-4
17	SGTC_790	1575-0012	3.35	79.1 µM	1.18E-4	TSC3-RPN4	53	3.99E-4
18	SGTC_1011	4112-3381	3.34	17.4 µM	1.26E-4		64	4.21E-4
19	SGTC_2093	5331342	3.32	194.4 µM	1.34E-4		39	4.43E-4
20	SGTC_2806	7952793	3.29	58.4 µM	1.53E-4		50	4.97E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.175	1.38E-24	YGL164C	YRB30	hom	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.139	6.48E-16	YDR036C	EHD3	hom	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.122	1.22E-12	YDR104C	SPO71	hom	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.122	1.51E-12	YBL086C_p	YBL086C_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.120	2.75E-12	YML084W_d	YML084W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.120	2.89E-12	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.116	1.62E-11	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.112	7.30E-11	YBR186W	PCH2	hom	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.111	1.21E-10	YOL017W	ESC8	hom	Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.110	1.63E-10	YGR251W	NOP19	het	Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.106	8.02E-10	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104	1.70E-9	YBL043W	ECM13	hom	Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.102	3.72E-9	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098	1.09E-8	YLR191W	PEX13	hom	Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.097	1.84E-8	YDR006C	SOK1	hom	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13