YDR152W / GIR2

Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR152W / GIR2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-4.37|P-value:4.68E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.34|P-value:3.55E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.74|P-value:8.62E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.13|P-value:7.44E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.49|P-value:2.30E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.74|P-value:8.64E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.36|P-value:3.80E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.75|P-value:7.01E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.14|P-value:1.63E-5 ID:SGTC_447|Compound:ml7|FD-Score:-3.09|P-value:8.50E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-3.05|P-value:9.68E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.39|P-value:3.35E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.51|P-value:2.91E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:5.58|P-value:1.02E-8 ID:SGTC_780|Compound:0109-0199|FD-Score:3.36|P-value:3.76E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.16|P-value:7.55E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.65|P-value:1.48E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.29|P-value:4.81E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.90|P-value:4.59E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.95|P-value:3.15E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.09|P-value:9.88E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.43|P-value:2.89E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.45|P-value:2.71E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.11|P-value:8.06E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.20|P-value:6.70E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.09|P-value:8.46E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.11|P-value:7.84E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.40|P-value:2.81E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.12|P-value:7.72E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.18|P-value:7.26E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.38|P-value:2.96E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-4.01|P-value:2.38E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.24|P-value:5.76E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.10|P-value:9.50E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.60|P-value:1.51E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.51|P-value:2.11E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.15|P-value:6.83E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-4.21|P-value:9.90E-6 ID:SGTC_2277|Compound:7947813|FD-Score:-3.29|P-value:4.22E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.33|P-value:3.61E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.73|P-value:9.11E-5 ID:SGTC_2325|Compound:6158266|FD-Score:4.81|P-value:6.66E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.83|P-value:5.02E-7 ID:SGTC_2477|Compound:5967686|FD-Score:-3.10|P-value:8.24E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.24|P-value:5.89E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.07|P-value:9.14E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.14|P-value:7.21E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.66|P-value:1.39E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.09|P-value:8.59E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.65|P-value:1.24E-6 ID:SGTC_2829|Compound:7992743|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_2862|Compound:9027634|FD-Score:5.68|P-value:5.60E-9 ID:SGTC_2869|Compound:9037858|FD-Score:-3.71|P-value:8.30E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.61|P-value:1.44E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.31|P-value:4.57E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.65|P-value:1.49E-6 ID:SGTC_3180|Compound:9109287|FD-Score:4.71|P-value:1.12E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.37|P-value:4.68E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.34|P-value:3.55E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.74|P-value:8.62E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.13|P-value:7.44E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.49|P-value:2.30E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.74|P-value:8.64E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.36|P-value:3.80E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.75|P-value:7.01E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.14|P-value:1.63E-5 ID:SGTC_447|Compound:ml7|FD-Score:-3.09|P-value:8.50E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-3.05|P-value:9.68E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.39|P-value:3.42E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.39|P-value:3.35E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.51|P-value:2.91E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:5.58|P-value:1.02E-8 ID:SGTC_780|Compound:0109-0199|FD-Score:3.36|P-value:3.76E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.16|P-value:7.55E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.65|P-value:1.48E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.29|P-value:4.81E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.90|P-value:4.59E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.95|P-value:3.15E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.09|P-value:9.88E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.43|P-value:2.89E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.45|P-value:2.71E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:-3.11|P-value:8.06E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.20|P-value:6.70E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.09|P-value:8.46E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.11|P-value:7.84E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.40|P-value:2.81E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.12|P-value:7.72E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.18|P-value:7.26E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.38|P-value:2.96E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-4.01|P-value:2.38E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.24|P-value:5.76E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.10|P-value:9.50E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.60|P-value:1.51E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.51|P-value:2.11E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.15|P-value:6.83E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-4.21|P-value:9.90E-6 ID:SGTC_2277|Compound:7947813|FD-Score:-3.29|P-value:4.22E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.33|P-value:3.61E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.73|P-value:9.11E-5 ID:SGTC_2325|Compound:6158266|FD-Score:4.81|P-value:6.66E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.83|P-value:5.02E-7 ID:SGTC_2477|Compound:5967686|FD-Score:-3.10|P-value:8.24E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.24|P-value:5.89E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.07|P-value:9.14E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.14|P-value:7.21E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.66|P-value:1.39E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.09|P-value:8.59E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.65|P-value:1.24E-6 ID:SGTC_2829|Compound:7992743|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_2862|Compound:9027634|FD-Score:5.68|P-value:5.60E-9 ID:SGTC_2869|Compound:9037858|FD-Score:-3.71|P-value:8.30E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.61|P-value:1.44E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.31|P-value:4.57E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.65|P-value:1.49E-6 ID:SGTC_3180|Compound:9109287|FD-Score:4.71|P-value:1.12E-6

Top fitness defect scores for YDR152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2862 9027634 5.68 71.4 µM 5.60E-9 ERG2 14 6.71E-9
2 SGTC_774 k060-0086 5.58 136.0 µM 1.02E-8 7 1.21E-8
3 SGTC_2325 6158266 4.81 200.0 µM 6.66E-7 12 7.47E-7
4 SGTC_3180 9109287 4.71 49.5 µM 1.12E-6 3 1.25E-6
5 SGTC_2620 irigenin 4.66 100.0 µM 1.39E-6 17 1.55E-6
6 SGTC_899 1083-0020 4.65 478.0 µM 1.48E-6 12 1.64E-6
7 SGTC_3174 9107204 4.65 49.5 µM 1.49E-6 ERG2 17 1.66E-6
8 SGTC_632 0781-2353 4.51 4.7 µM 2.91E-6 Golgi 25 3.21E-6
9 SGTC_427 1354-0053 4.14 47.3 µM 1.63E-5 16 1.75E-5
10 SGTC_1499 4480-0877 4.06 67.3 µM 2.26E-5 6 2.43E-5
11 SGTC_910 3454-3003 3.90 490.0 µM 4.59E-5 15 4.88E-5
12 SGTC_76 0433-0009 3.74 400.3 µM 8.62E-5 16 9.10E-5
13 SGTC_265 mycophenolic acid 3.74 32.9 µM 8.64E-5 RPP1 & pyrimidine depletion 25 9.12E-5
14 SGTC_2308 7584454 3.73 197.6 µM 9.11E-5 25 9.61E-5
15 SGTC_2303 7774051 3.65 200.0 µM 1.26E-4 30 1.33E-4
16 SGTC_2905 7799065 3.61 20.1 µM 1.44E-4 17 1.51E-4
17 SGTC_1885 st057546 3.60 99.9 µM 1.51E-4 27 1.58E-4
18 SGTC_2101 5377231 3.52 179.2 µM 2.05E-4 13 2.14E-4
19 SGTC_2035 5154463 3.51 94.6 µM 2.11E-4 25 2.21E-4
20 SGTC_183 3914-0051 3.49 30.6 µM 2.30E-4 60S ribosome export 34 2.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.084 9.61E-7 YOR253W NAT5 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.079 4.46E-6 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.077 9.44E-6 YDR461W MFA1 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2
0.075 1.39E-5 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.074 1.61E-5 YBR293W VBA2 hom Permease of basic amino acids in the vacuolar membrane
0.074 1.84E-5 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.073 2.08E-5 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
0.070 5.17E-5 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.069 5.73E-5 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.068 7.44E-5 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.068 7.68E-5 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.066 1.36E-4 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.066 1.45E-4 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.065 1.62E-4 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.065 1.86E-4 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes