HIPHOP chemogenomics database

YDR155C / CPR1

Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR155C / CPR1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR155C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2564	betulinic acid	6.53	100.0 µM	1.41E-12		6	3.32E-11
2	SGTC_45	0kpi-0036	6.43	14.9 µM	3.05E-12	excess fatty acid	3	6.50E-11
3	SGTC_145	3737-0113	6.42	38.4 µM	3.11E-12	DNA intercalators	21	6.62E-11
4	SGTC_115	0527-0192	5.44	112.0 µM	3.12E-9		19	2.71E-8
5	SGTC_214	4373-3496	4.65	70.0 µM	3.49E-7		38	1.65E-6
6	SGTC_1153	4055-0057	4.36	267.0 µM	1.68E-6		16	6.53E-6
7	SGTC_1232	0279-0259	4.32	161.0 µM	2.01E-6		7	7.65E-6
8	SGTC_379	3970-0972	4.31	5.9 µM	2.18E-6	tubulin folding & SWR complex	29	8.20E-6
9	SGTC_684	1140-0066	4.05	328.0 µM	8.05E-6	Golgi	20	2.57E-5
10	SGTC_574	1315-0397	4.00	40.0 µM	1.02E-5		36	3.16E-5
11	SGTC_1227	3909-8010	3.96	46.6 µM	1.24E-5		18	3.76E-5
12	SGTC_905	2-aminofluorene	3.91	215.0 µM	1.58E-5	cell wall signaling	29	4.64E-5
13	SGTC_566	0958-0068	3.76	16.5 µM	3.11E-5	RSC & ERG11	21	8.40E-5
14	SGTC_1547	harmine	3.74	94.2 µM	3.45E-5	ergosterol biosynthesis	55	9.22E-5
15	SGTC_3037	9091026	3.68	49.5 µM	4.41E-5	NEO1-PIK1	140	1.14E-4
16	SGTC_2707	st078556	3.64	66.6 µM	5.34E-5		16	1.35E-4
17	SGTC_2611	pyromycin	3.62	23.9 µM	5.96E-5		42	1.49E-4
18	SGTC_205	1486-1330	3.56	71.9 µM	7.68E-5		25	1.86E-4
19	SGTC_3065	9113888	3.53	49.5 µM	8.53E-5		36	2.04E-4
20	SGTC_131	0141-0277	3.53	33.9 µM	8.76E-5		56	2.09E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.213	8.19E-36	YNL124W	NAF1	het	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.198	6.65E-31	YDR401W_d	YDR401W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.193	1.70E-29	YGL002W	ERP6	hom	Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.190	1.42E-28	YHR149C	SKG6	hom	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.185	3.53E-27	YNR008W	LRO1	hom	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.175	2.15E-24	YOR077W	RTS2	het	Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.163	1.92E-21	YGL118C_d	YGL118C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.163	2.98E-21	YEL064C	AVT2	hom	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.162	5.06E-21	YFL022C	FRS2	het	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.145	2.73E-17	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.128	9.50E-14	YNL264C	PDR17	hom	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.128	1.33E-13	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.127	1.66E-13	YEL017C-A	PMP2	hom	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.126	2.94E-13	YHR020W	YHR020W	het	Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.124	5.60E-13	YDR524W-C_p	YDR524W-C_p	hom	Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin