YDR156W / RPA14

RNA polymerase I subunit A14

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR156W / RPA14

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.17|P-value:6.28E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.88|P-value:1.87E-16 ID:SGTC_87|Compound:0100-0052|FD-Score:3.73|P-value:3.30E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.28|P-value:2.55E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.59|P-value:1.54E-9 ID:SGTC_297|Compound:0986-0032|FD-Score:2.88|P-value:9.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.81|P-value:1.15E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:2.97|P-value:6.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.31|P-value:3.79E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.00|P-value:6.29E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.08|P-value:4.67E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.50|P-value:9.08E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.02|P-value:5.91E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.60|P-value:5.90E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.99|P-value:6.42E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.34|P-value:3.42E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.13|P-value:3.95E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.21|P-value:2.84E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.71|P-value:3.59E-5 ID:SGTC_1660|Compound:st012960|FD-Score:-3.29|P-value:4.07E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.82|P-value:2.28E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.14|P-value:7.06E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.13|P-value:3.89E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.55|P-value:1.47E-4 ID:SGTC_1763|Compound:st044482|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-3.29|P-value:4.14E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.27|P-value:2.63E-6 ID:SGTC_1982|Compound:st072467|FD-Score:-3.05|P-value:9.75E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.20|P-value:5.69E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.67|P-value:4.32E-5 ID:SGTC_2119|Compound:5528445|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.28|P-value:2.14E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.07|P-value:9.06E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.98|P-value:6.68E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.18|P-value:6.18E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.89|P-value:9.74E-8 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.06|P-value:3.76E-8 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.14|P-value:3.74E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.16|P-value:6.50E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-4.04|P-value:1.84E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.32|P-value:1.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.88|P-value:3.75E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.30|P-value:3.92E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.31|P-value:1.93E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.34|P-value:3.33E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.24|P-value:2.50E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.51|P-value:2.77E-12 ID:SGTC_2793|Compound:7325131|FD-Score:-3.42|P-value:2.52E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.05|P-value:9.66E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-4.48|P-value:2.24E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.82|P-value:4.89E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-3.32|P-value:3.65E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.53|P-value:1.60E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.17|P-value:6.28E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.88|P-value:1.87E-16 ID:SGTC_87|Compound:0100-0052|FD-Score:3.73|P-value:3.30E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.36|P-value:1.56E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.28|P-value:2.55E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.59|P-value:1.54E-9 ID:SGTC_297|Compound:0986-0032|FD-Score:2.88|P-value:9.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.81|P-value:1.15E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:2.97|P-value:6.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.31|P-value:3.79E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.00|P-value:6.29E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.08|P-value:4.67E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.50|P-value:9.08E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:3.02|P-value:5.91E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.60|P-value:5.90E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.99|P-value:6.42E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.34|P-value:3.42E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.13|P-value:3.95E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.21|P-value:2.84E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.71|P-value:3.59E-5 ID:SGTC_1660|Compound:st012960|FD-Score:-3.29|P-value:4.07E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.82|P-value:2.28E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.14|P-value:7.06E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.13|P-value:3.89E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.55|P-value:1.47E-4 ID:SGTC_1763|Compound:st044482|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-3.29|P-value:4.14E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.27|P-value:2.63E-6 ID:SGTC_1982|Compound:st072467|FD-Score:-3.05|P-value:9.75E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.20|P-value:5.69E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.67|P-value:4.32E-5 ID:SGTC_2119|Compound:5528445|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.28|P-value:2.14E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.07|P-value:9.06E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.98|P-value:6.68E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.18|P-value:6.18E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.89|P-value:9.74E-8 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:5.06|P-value:3.76E-8 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.14|P-value:3.74E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.16|P-value:6.50E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-4.04|P-value:1.84E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.32|P-value:1.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.88|P-value:3.75E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.30|P-value:3.92E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.31|P-value:1.93E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.34|P-value:3.33E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.24|P-value:2.50E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.51|P-value:2.77E-12 ID:SGTC_2793|Compound:7325131|FD-Score:-3.42|P-value:2.52E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-3.05|P-value:9.66E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-4.48|P-value:2.24E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-3.82|P-value:4.89E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-3.32|P-value:3.65E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.53|P-value:1.60E-4

Top fitness defect scores for YDR156W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 6.51 96.7 µM 2.77E-12 calcium & mitochondrial duress 129 3.80E-11
2 SGTC_221 trifluoperazine 5.59 10.3 µM 1.54E-9 NEO1-PIK1 140 1.16E-8
3 SGTC_2496 diffractaic acid 5.06 79.8 µM 3.76E-8 9 2.09E-7
4 SGTC_2476 5806916 4.89 10.5 µM 9.74E-8 5 4.94E-7
5 SGTC_114 0364-0001 4.28 490.3 µM 2.55E-6 40 9.42E-6
6 SGTC_1908 st060353 4.27 56.5 µM 2.63E-6 RPP1 & pyrimidine depletion 29 9.68E-6
7 SGTC_1712 st032288 3.82 53.4 µM 2.28E-5 calcium & mitochondrial duress 196 6.80E-5
8 SGTC_87 0100-0052 3.73 35.5 µM 3.30E-5 126 9.49E-5
9 SGTC_1421 4029-0249 3.71 71.4 µM 3.59E-5 20 1.02E-4
10 SGTC_2097 5376186 3.67 200.0 µM 4.32E-5 32 1.21E-4
11 SGTC_782 0083-0095 3.60 30.5 µM 5.90E-5 46 1.60E-4
12 SGTC_626 0214-0009 3.50 33.0 µM 9.08E-5 copper-dependent oxidative stress 33 2.36E-4
13 SGTC_88 0180-0332 3.36 8.7 µM 1.56E-4 41 3.84E-4
14 SGTC_2570 licareol 3.32 100.0 µM 1.87E-4 57 4.53E-4
15 SGTC_2606 farnesol 3.31 9.8 µM 1.93E-4 45 4.66E-4
16 SGTC_2166 5933061 3.28 31.5 µM 2.14E-4 tubulin folding & SWR complex 66 5.11E-4
17 SGTC_2639 lactacystin 3.24 53.0 µM 2.50E-4 53 5.88E-4
18 SGTC_1271 0832-2808 3.21 169.0 µM 2.84E-4 33 6.60E-4
19 SGTC_1191 1487-1166 3.17 10.6 µM 3.32E-4 azole & statin 59 7.58E-4
20 SGTC_2497 7-hydroxyflavone 3.14 100.0 µM 3.74E-4 45 8.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 1.38E-50 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.223 6.34E-39 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.201 6.71E-32 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.193 1.31E-29 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.192 3.21E-29 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.191 7.05E-29 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.187 1.07E-27 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.182 2.08E-26 YDL136W RPL35B hom Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.179 1.76E-25 YBL083C_d YBL083C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
0.177 4.84E-25 YDR125C ECM18 hom Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication
0.175 2.24E-24 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.174 3.61E-24 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.173 4.91E-24 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.172 8.24E-24 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.172 1.51E-23 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication