YDR186C

Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR186C / YDR186C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.11|P-value:1.60E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:12.20|P-value:8.06E-35 ID:SGTC_197|Compound:4544-0043|FD-Score:3.38|P-value:3.04E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.04|P-value:0.00100 ID:SGTC_313|Compound:3474-0040|FD-Score:3.11|P-value:7.96E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:9.79|P-value:3.41E-23 ID:SGTC_384|Compound:k007-0144|FD-Score:10.90|P-value:1.81E-28 ID:SGTC_424|Compound:splitomicin|FD-Score:4.19|P-value:1.10E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:8.09|P-value:1.82E-16 ID:SGTC_497|Compound:capsazepine|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.33|P-value:5.05E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.91|P-value:3.47E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.06|P-value:9.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.53|P-value:2.22E-11 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.64|P-value:1.62E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.74|P-value:7.52E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:12.30|P-value:2.48E-35 ID:SGTC_753|Compound:1322-0200|FD-Score:3.90|P-value:3.81E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.35|P-value:7.70E-11 ID:SGTC_953|Compound:1188-0045|FD-Score:3.67|P-value:9.80E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.87|P-value:4.36E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.75|P-value:7.77E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.14|P-value:7.00E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:15.90|P-value:1.14E-57 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.82|P-value:5.48E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.95|P-value:3.15E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.26|P-value:6.49E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.80|P-value:9.72E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.14|P-value:9.97E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.16|P-value:6.67E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-3.54|P-value:2.39E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.47|P-value:3.06E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.66|P-value:1.20E-6 ID:SGTC_1658|Compound:st012944|FD-Score:4.77|P-value:7.11E-7 ID:SGTC_1712|Compound:st032288|FD-Score:3.17|P-value:6.45E-4 ID:SGTC_1736|Compound:st036774|FD-Score:6.85|P-value:2.48E-12 ID:SGTC_1800|Compound:st050079|FD-Score:3.26|P-value:4.63E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.07|P-value:1.85E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.66|P-value:1.20E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.53|P-value:2.45E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.41|P-value:2.65E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.63|P-value:1.40E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.45|P-value:2.34E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.28|P-value:4.29E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.51|P-value:2.67E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.25|P-value:6.70E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.16|P-value:9.14E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.45|P-value:1.87E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:3.62|P-value:1.21E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.83|P-value:7.58E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.22|P-value:7.58E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.42|P-value:3.63E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.11|P-value:1.60E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:12.20|P-value:8.06E-35 ID:SGTC_197|Compound:4544-0043|FD-Score:3.38|P-value:3.04E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.04|P-value:0.00100 ID:SGTC_313|Compound:3474-0040|FD-Score:3.11|P-value:7.96E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:9.79|P-value:3.41E-23 ID:SGTC_384|Compound:k007-0144|FD-Score:10.90|P-value:1.81E-28 ID:SGTC_424|Compound:splitomicin|FD-Score:4.19|P-value:1.10E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:8.09|P-value:1.82E-16 ID:SGTC_497|Compound:capsazepine|FD-Score:3.79|P-value:6.00E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.33|P-value:5.05E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.91|P-value:3.47E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.06|P-value:9.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.53|P-value:2.22E-11 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.64|P-value:1.62E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.74|P-value:7.52E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:12.30|P-value:2.48E-35 ID:SGTC_753|Compound:1322-0200|FD-Score:3.90|P-value:3.81E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.35|P-value:7.70E-11 ID:SGTC_953|Compound:1188-0045|FD-Score:3.67|P-value:9.80E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.87|P-value:4.36E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.75|P-value:7.77E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.14|P-value:7.00E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:15.90|P-value:1.14E-57 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.82|P-value:5.48E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.95|P-value:3.15E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.26|P-value:6.49E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.80|P-value:9.72E-7 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.14|P-value:9.97E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.16|P-value:6.67E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-3.54|P-value:2.39E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.47|P-value:3.06E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.66|P-value:1.20E-6 ID:SGTC_1658|Compound:st012944|FD-Score:4.77|P-value:7.11E-7 ID:SGTC_1712|Compound:st032288|FD-Score:3.17|P-value:6.45E-4 ID:SGTC_1736|Compound:st036774|FD-Score:6.85|P-value:2.48E-12 ID:SGTC_1800|Compound:st050079|FD-Score:3.26|P-value:4.63E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.07|P-value:1.85E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.66|P-value:1.20E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.53|P-value:2.45E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.41|P-value:2.65E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.63|P-value:1.40E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.45|P-value:2.34E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.28|P-value:4.29E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.51|P-value:2.67E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.25|P-value:6.70E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.16|P-value:9.14E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.45|P-value:1.87E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:3.62|P-value:1.21E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.83|P-value:7.58E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.22|P-value:7.58E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.42|P-value:3.63E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.26|P-value:4.64E-4

Top fitness defect scores for YDR186C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1161 k007-0610 15.90 110.0 µM 1.14E-57 ERAD & cell cycle 4 3.26E-57
2 SGTC_733 4069-0007 12.30 56.1 µM 2.48E-35 ERAD & cell cycle 9 5.32E-35
3 SGTC_103 0844-0104 12.20 51.8 µM 8.06E-35 ERAD & cell cycle 16 1.72E-34
4 SGTC_384 k007-0144 10.90 5.2 µM 1.81E-28 ERAD & cell cycle 9 3.51E-28
5 SGTC_373 0844-0104 9.79 25.9 µM 3.41E-23 ERAD & cell cycle 10 6.10E-23
6 SGTC_451 chloral hydrate 8.09 100.0 µM 1.82E-16 5 2.91E-16
7 SGTC_1736 st036774 6.85 51.0 µM 2.48E-12 4 3.65E-12
8 SGTC_568 1193-0097 6.53 7.5 µM 2.22E-11 ERAD & cell cycle 53 3.20E-11
9 SGTC_805 3852-0218 6.35 479.0 µM 7.70E-11 ERAD & cell cycle 22 1.10E-10
10 SGTC_2582 agaric acid 5.45 100.0 µM 1.87E-8 redox potentiating 193 2.53E-8
11 SGTC_547 1120-0019 4.91 610.0 nM 3.47E-7 azole & statin 17 4.56E-7
12 SGTC_1658 st012944 4.77 20.0 µM 7.11E-7 iron homeostasis 53 9.25E-7
13 SGTC_1094 duloxetine 4.75 25.4 µM 7.77E-7 RPP1 & pyrimidine depletion 5 1.01E-6
14 SGTC_2130 NSC 7 4.66 2.5 µM 1.20E-6 copper-dependent oxidative stress 12 1.56E-6
15 SGTC_1597 7-benzyloxygramine 4.66 47.5 µM 1.20E-6 calcium & mitochondrial duress 79 1.56E-6
16 SGTC_2285 7945142 4.63 200.0 µM 1.40E-6 10 1.81E-6
17 SGTC_424 splitomicin 4.19 100.0 mM 1.10E-5 16 1.39E-5
18 SGTC_67 0335-0847 4.11 266.0 µM 1.60E-5 ubiquinone biosynthesis & proteasome 111 2.01E-5
19 SGTC_352 k048-0007 4.09 5.1 µM 1.70E-5 ERAD & cell cycle 73 2.13E-5
20 SGTC_2085 5307070 4.07 144.1 µM 1.85E-5 superoxide 25 2.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.628 0 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.518 6.56E-230 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.490 1.42E-202 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.486 2.87E-198 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.465 9.10E-180 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.418 5.67E-142 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.410 1.85E-136 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.397 2.56E-127 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.387 1.62E-120 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.383 1.77E-117 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.346 6.61E-95 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.344 4.15E-94 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.333 1.64E-87 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.328 5.26E-85 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.327 2.39E-84 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo