YDR187C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR187C / YDR187C

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.78|P-value:4.03E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.19|P-value:1.01E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:5.15|P-value:2.42E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:4.35|P-value:5.74E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:10.10|P-value:1.78E-19 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.48|P-value:9.42E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.65|P-value:6.05E-4 ID:SGTC_228|Compound:caffeine|FD-Score:5.47|P-value:6.03E-7 ID:SGTC_229|Compound:benomyl|FD-Score:11.40|P-value:2.96E-24 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.55|P-value:8.33E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:5.18|P-value:2.11E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.87|P-value:3.01E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:6.06|P-value:3.64E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:5.40|P-value:8.12E-7 ID:SGTC_435|Compound:c-PAF|FD-Score:3.80|P-value:3.75E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.54|P-value:7.76E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.98|P-value:2.08E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.50|P-value:8.77E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.86|P-value:7.97E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:4.91|P-value:6.49E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.68|P-value:5.57E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.66|P-value:1.76E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:5.21|P-value:1.85E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:3.96|P-value:2.19E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.71|P-value:5.07E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.48|P-value:9.40E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-5.40|P-value:7.43E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:3.51|P-value:9.19E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.89|P-value:2.79E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:6.26|P-value:1.39E-8 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.24|P-value:1.46E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.84|P-value:3.29E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.30|P-value:6.73E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.42|P-value:4.34E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.28|P-value:7.26E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.57|P-value:7.69E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.31|P-value:6.59E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.02|P-value:1.81E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.23|P-value:1.71E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.30|P-value:1.25E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.26|P-value:7.10E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.66|P-value:5.51E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.70|P-value:5.24E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.32|P-value:6.40E-5 ID:SGTC_1643|Compound:st009866|FD-Score:6.62|P-value:2.06E-9 ID:SGTC_1845|Compound:st056753|FD-Score:3.95|P-value:2.32E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:10.60|P-value:2.43E-21 ID:SGTC_1897|Compound:st060201|FD-Score:4.87|P-value:7.66E-6 ID:SGTC_1906|Compound:st060206|FD-Score:-3.78|P-value:3.67E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.49|P-value:9.81E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.68|P-value:5.10E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.58|P-value:7.47E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.55|P-value:8.20E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.50|P-value:3.30E-5 ID:SGTC_2214|Compound:7179297|FD-Score:5.01|P-value:4.41E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.78|P-value:4.03E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-3.98|P-value:1.89E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.88|P-value:2.93E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.58|P-value:2.40E-5 ID:SGTC_2393|Compound:9031399|FD-Score:4.65|P-value:1.82E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.92|P-value:7.50E-8 ID:SGTC_2451|Compound:5856223|FD-Score:4.10|P-value:1.37E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.64|P-value:6.32E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.40|P-value:8.33E-7 ID:SGTC_2534|Compound:helenine|FD-Score:-4.12|P-value:1.19E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.35|P-value:5.79E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.79|P-value:3.95E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.15|P-value:1.06E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.47|P-value:9.68E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.32|P-value:6.30E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.75|P-value:4.10E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.48|P-value:9.51E-4 ID:SGTC_2787|Compound:5284540|FD-Score:5.06|P-value:3.53E-6 ID:SGTC_2837|Compound:9008476|FD-Score:3.66|P-value:5.83E-4 ID:SGTC_2883|Compound:9059145|FD-Score:5.55|P-value:4.18E-7 ID:SGTC_3105|Compound:9121040|FD-Score:-3.68|P-value:5.11E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.06|P-value:1.58E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.86|P-value:3.12E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.04|P-value:1.68E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.64|P-value:5.82E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.89|P-value:8.58E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:3.78|P-value:4.03E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.19|P-value:1.01E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:5.15|P-value:2.42E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:4.35|P-value:5.74E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:10.10|P-value:1.78E-19 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.48|P-value:9.42E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.65|P-value:6.05E-4 ID:SGTC_228|Compound:caffeine|FD-Score:5.47|P-value:6.03E-7 ID:SGTC_229|Compound:benomyl|FD-Score:11.40|P-value:2.96E-24 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.55|P-value:8.33E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:5.18|P-value:2.11E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.87|P-value:3.01E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:6.06|P-value:3.64E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:5.40|P-value:8.12E-7 ID:SGTC_435|Compound:c-PAF|FD-Score:3.80|P-value:3.75E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.54|P-value:7.76E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.98|P-value:2.08E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.50|P-value:8.77E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.86|P-value:7.97E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:4.91|P-value:6.49E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.68|P-value:5.57E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.66|P-value:1.76E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:5.21|P-value:1.85E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:3.96|P-value:2.19E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.71|P-value:5.07E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.48|P-value:9.40E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-5.40|P-value:7.43E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:3.51|P-value:9.19E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.89|P-value:2.79E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:6.26|P-value:1.39E-8 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.24|P-value:1.46E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.84|P-value:3.29E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.30|P-value:6.73E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.42|P-value:4.34E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.28|P-value:7.26E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.57|P-value:7.69E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.31|P-value:6.59E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.02|P-value:1.81E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.23|P-value:1.71E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.30|P-value:1.25E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.26|P-value:7.10E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.66|P-value:5.51E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.70|P-value:5.24E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.32|P-value:6.40E-5 ID:SGTC_1643|Compound:st009866|FD-Score:6.62|P-value:2.06E-9 ID:SGTC_1845|Compound:st056753|FD-Score:3.95|P-value:2.32E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:10.60|P-value:2.43E-21 ID:SGTC_1897|Compound:st060201|FD-Score:4.87|P-value:7.66E-6 ID:SGTC_1906|Compound:st060206|FD-Score:-3.78|P-value:3.67E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.49|P-value:9.81E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.68|P-value:5.10E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.58|P-value:7.47E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.55|P-value:8.20E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.50|P-value:3.30E-5 ID:SGTC_2214|Compound:7179297|FD-Score:5.01|P-value:4.41E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.78|P-value:4.03E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-3.98|P-value:1.89E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.88|P-value:2.93E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.58|P-value:2.40E-5 ID:SGTC_2393|Compound:9031399|FD-Score:4.65|P-value:1.82E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.92|P-value:7.50E-8 ID:SGTC_2451|Compound:5856223|FD-Score:4.10|P-value:1.37E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.64|P-value:6.32E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.40|P-value:8.33E-7 ID:SGTC_2534|Compound:helenine|FD-Score:-4.12|P-value:1.19E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.35|P-value:5.79E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.79|P-value:3.95E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.15|P-value:1.06E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.47|P-value:9.68E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.32|P-value:6.30E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.75|P-value:4.10E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.48|P-value:9.51E-4 ID:SGTC_2787|Compound:5284540|FD-Score:5.06|P-value:3.53E-6 ID:SGTC_2837|Compound:9008476|FD-Score:3.66|P-value:5.83E-4 ID:SGTC_2883|Compound:9059145|FD-Score:5.55|P-value:4.18E-7 ID:SGTC_3105|Compound:9121040|FD-Score:-3.68|P-value:5.11E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.06|P-value:1.58E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.86|P-value:3.12E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.04|P-value:1.68E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.64|P-value:5.82E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.89|P-value:8.58E-8

Top fitness defect scores for YDR187C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_229 benomyl 11.40 22.9 µM 2.96E-24 tubulin folding & SWR complex 1 3.40E-30 1.64
2 SGTC_1875 nocodazole 10.60 6.0 µM 2.43E-21 tubulin folding & SWR complex 8 1.62E-26 1.32
3 SGTC_212 3807-4682 10.10 38.8 µM 1.78E-19 tubulin folding & SWR complex 2 3.67E-24 0.14
4 SGTC_1643 st009866 6.62 20.2 µM 2.06E-9 9 1.78E-11 0.84
5 SGTC_1049 3226-0134 6.26 66.0 µM 1.39E-8 3 1.96E-10 1.21
6 SGTC_325 2810-4341 6.06 181.0 µM 3.64E-8 amide catabolism 1 6.61E-10 0.92
7 SGTC_2405 ticlatone 5.92 3.5 µM 7.50E-8 7 1.64E-9 0.35
8 SGTC_3266 9136860 5.89 49.5 µM 8.58E-8 cell wall 5 1.95E-9 0.32
9 SGTC_2883 9059145 5.55 45.5 µM 4.18E-7 1 1.43E-8 0.88
10 SGTC_228 caffeine 5.47 993.1 µM 6.03E-7 1 2.26E-8 0.99
11 SGTC_375 3970-0961 5.40 9.3 µM 8.12E-7 tubulin folding & SWR complex 4 3.28E-8 0.53
12 SGTC_2526 patulin 5.40 37.6 µM 8.33E-7 5 3.39E-8 0.03
13 SGTC_1557 sumaresinolic acid 5.30 42.3 µM 1.25E-6 3 5.65E-8 1.39
14 SGTC_1545 lovastatin 5.23 49.4 µM 1.71E-6 3 8.38E-8 0.50
15 SGTC_861 0443-0273 5.21 110.0 µM 1.85E-6 2 9.21E-8 0.32
16 SGTC_287 k060-0039 5.18 29.6 µM 2.11E-6 3 1.09E-7 0.43
17 SGTC_194 1486-1323 5.15 56.9 µM 2.42E-6 1 1.29E-7 0.39
18 SGTC_2787 5284540 5.06 71.4 µM 3.53E-6 4 2.08E-7 0.04
19 SGTC_2214 7179297 5.01 48.3 µM 4.41E-6 superoxide 1 2.75E-7 0.53
20 SGTC_747 3448-8087 4.91 38.7 µM 6.49E-6 4 4.47E-7 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.336 2.46E-89 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.327 1.59E-84 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.297 2.26E-69 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.278 1.09E-60 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.249 1.13E-48 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.248 4.20E-48 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.235 1.74E-43 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.234 6.26E-43 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.230 1.47E-41 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.223 3.34E-39 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.223 4.77E-39 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.222 8.33E-39 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.193 2.17E-29 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.189 2.13E-28 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.168 1.37E-22 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes