YDR194C / MSS116

DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR194C / MSS116

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.52|P-value:7.93E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.57|P-value:3.34E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.52|P-value:7.96E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:4.80|P-value:2.25E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.43|P-value:9.90E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.63|P-value:7.26E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:9.72|P-value:6.61E-21 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.68|P-value:8.28E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:7.64|P-value:1.34E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.30|P-value:2.04E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.87|P-value:9.68E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.33|P-value:6.63E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.52|P-value:3.97E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.82|P-value:1.08E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.16|P-value:1.54E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:3.36|P-value:6.85E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.48|P-value:4.47E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:5.10E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.61|P-value:2.87E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.09|P-value:5.66E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:6.69E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.26|P-value:9.30E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.55|P-value:3.50E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.28|P-value:1.86E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.64|P-value:2.53E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.72|P-value:2.21E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.48|P-value:4.43E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.44|P-value:9.81E-8 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.29|P-value:8.50E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.52|P-value:3.95E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.24|P-value:2.68E-7 ID:SGTC_1623|Compound:st003709|FD-Score:4.21|P-value:2.92E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.71|P-value:1.98E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.91|P-value:8.06E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.07|P-value:4.36E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.45|P-value:4.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.57|P-value:4.20E-8 ID:SGTC_1742|Compound:st038235|FD-Score:5.33|P-value:1.74E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.37|P-value:1.14E-7 ID:SGTC_1884|Compound:5633444|FD-Score:-4.42|P-value:1.04E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.46|P-value:4.78E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.01|P-value:7.07E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.77|P-value:1.72E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.61|P-value:5.38E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.47|P-value:4.11E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.65|P-value:2.20E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.62|P-value:2.78E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.43|P-value:4.62E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.68|P-value:2.19E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.19|P-value:3.10E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.22|P-value:9.57E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.13|P-value:4.04E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.84|P-value:1.25E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.34|P-value:1.44E-5 ID:SGTC_2780|Compound:5215298|FD-Score:-3.53|P-value:3.32E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.39|P-value:6.05E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.82|P-value:1.72E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.62|P-value:2.75E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.40|P-value:3.31E-16 ID:SGTC_2900|Compound:5328528|FD-Score:3.26|P-value:9.37E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.74|P-value:2.06E-8 ID:SGTC_2934|Compound:9036370|FD-Score:-3.29|P-value:7.57E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-5.00|P-value:7.35E-7 ID:SGTC_2940|Compound:9060638|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.01|P-value:6.48E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.47|P-value:4.61E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.61|P-value:5.24E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-5.63|P-value:3.00E-8 ID:SGTC_3193|Compound:9111931|FD-Score:3.53|P-value:3.81E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.97|P-value:7.58E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.70|P-value:1.82E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.28|P-value:7.72E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.52|P-value:7.93E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.57|P-value:3.34E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.52|P-value:7.96E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:4.80|P-value:2.25E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.43|P-value:9.90E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.63|P-value:7.26E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:9.72|P-value:6.61E-21 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.68|P-value:8.28E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:7.64|P-value:1.34E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.30|P-value:2.04E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.87|P-value:9.68E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.33|P-value:6.63E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.52|P-value:3.97E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.82|P-value:1.08E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.16|P-value:1.54E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:3.36|P-value:6.85E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.48|P-value:4.47E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:5.10E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.61|P-value:2.87E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.09|P-value:5.66E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:6.69E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.26|P-value:9.30E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.55|P-value:3.50E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.28|P-value:1.86E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.64|P-value:2.53E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.72|P-value:2.21E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.48|P-value:4.43E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.44|P-value:9.81E-8 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.29|P-value:8.50E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.52|P-value:3.95E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.24|P-value:2.68E-7 ID:SGTC_1623|Compound:st003709|FD-Score:4.21|P-value:2.92E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.71|P-value:1.98E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.91|P-value:8.06E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.07|P-value:4.36E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.45|P-value:4.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.57|P-value:4.20E-8 ID:SGTC_1742|Compound:st038235|FD-Score:5.33|P-value:1.74E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.37|P-value:1.14E-7 ID:SGTC_1884|Compound:5633444|FD-Score:-4.42|P-value:1.04E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.46|P-value:4.78E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.01|P-value:7.07E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.77|P-value:1.72E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.61|P-value:5.38E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.47|P-value:4.11E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.65|P-value:2.20E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.62|P-value:2.78E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.43|P-value:4.62E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.68|P-value:2.19E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.19|P-value:3.10E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.22|P-value:9.57E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.13|P-value:4.04E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.84|P-value:1.25E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.34|P-value:1.44E-5 ID:SGTC_2780|Compound:5215298|FD-Score:-3.53|P-value:3.32E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.39|P-value:6.05E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.82|P-value:1.72E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.62|P-value:2.75E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.40|P-value:3.31E-16 ID:SGTC_2900|Compound:5328528|FD-Score:3.26|P-value:9.37E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.74|P-value:2.06E-8 ID:SGTC_2934|Compound:9036370|FD-Score:-3.29|P-value:7.57E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-5.00|P-value:7.35E-7 ID:SGTC_2940|Compound:9060638|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.01|P-value:6.48E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.47|P-value:4.61E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.61|P-value:5.24E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-5.63|P-value:3.00E-8 ID:SGTC_3193|Compound:9111931|FD-Score:3.53|P-value:3.81E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.97|P-value:7.58E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.70|P-value:1.82E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.28|P-value:7.72E-4

Top fitness defect scores for YDR194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.72 5.3 µM 6.61E-21 200 1.24E-22
2 SGTC_173 1273-0061 8.63 2.7 µM 7.26E-17 mitochondrial stress 56 3.08E-18
3 SGTC_310 1273-0058 7.64 1.1 µM 1.34E-13 mitochondrial stress 101 1.10E-14
4 SGTC_275 trichlorophene 6.68 5.7 µM 8.28E-11 mitochondrial stress 96 1.19E-11
5 SGTC_2232 chlorophetanol 5.77 41.5 µM 1.72E-8 TRP & mitochondrial translation 46 3.97E-9
6 SGTC_2932 9016711 5.74 44.5 µM 2.06E-8 14 4.81E-9
7 SGTC_1017 4239-0030 5.72 168.0 µM 2.21E-8 5 5.20E-9
8 SGTC_1456 k015-0012 5.44 13.0 µM 9.81E-8 6 2.63E-8
9 SGTC_1742 st038235 5.33 28.9 µM 1.74E-7 mitochondrial stress 66 4.91E-8
10 SGTC_1622 st003707 5.24 19.4 µM 2.68E-7 calcium & mitochondrial duress 15 7.84E-8
11 SGTC_767 0929-0023 5.09 86.0 µM 5.66E-7 TRP & mitochondrial translation 34 1.77E-7
12 SGTC_63 0099-0242 4.80 26.7 µM 2.25E-6 mitochondrial stress 64 7.94E-7
13 SGTC_3140 9094243 4.61 49.5 µM 5.24E-6 18 1.99E-6
14 SGTC_2250 alverine citrate 4.61 130.0 µM 5.38E-6 114 2.04E-6
15 SGTC_10 0279-0212 4.52 42.6 µM 7.93E-6 TRP & mitochondrial translation 92 3.12E-6
16 SGTC_28 pentachloropyridine N-oxide 4.52 1.6 µM 7.96E-6 TSC3-RPN4 45 3.13E-6
17 SGTC_314 1671-0008 4.30 2.7 µM 2.04E-5 37 8.71E-6
18 SGTC_1623 st003709 4.21 20.3 µM 2.92E-5 calcium & mitochondrial duress 58 1.29E-5
19 SGTC_2617 dihydrotanshinone i 4.19 20.8 µM 3.10E-5 copper-dependent oxidative stress 35 1.37E-5
20 SGTC_708 3448-5400 4.19 146.0 µM 3.16E-5 39 1.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.522 7.44E-234 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.518 2.19E-229 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.488 1.03E-199 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.478 9.36E-191 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.476 2.74E-189 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.472 2.33E-185 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.466 2.56E-180 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.465 5.84E-180 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.464 2.23E-178 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.463 8.78E-178 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.452 5.25E-169 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.451 8.81E-168 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.449 3.98E-166 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.445 7.22E-163 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.443 5.16E-161 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss