YDR199W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR199W / YDR199W

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:-3.77|P-value:1.51E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.72|P-value:4.06E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:11.90|P-value:1.84E-29 ID:SGTC_143|Compound:4032-1194|FD-Score:4.30|P-value:2.87E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.36|P-value:2.23E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.38|P-value:2.03E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.48|P-value:1.38E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.30|P-value:1.97E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:7.26|P-value:4.28E-12 ID:SGTC_375|Compound:3970-0961|FD-Score:3.50|P-value:5.40E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:8.54|P-value:4.79E-16 ID:SGTC_568|Compound:1193-0097|FD-Score:12.40|P-value:8.87E-32 ID:SGTC_733|Compound:4069-0007|FD-Score:6.05|P-value:6.82E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:5.66|P-value:5.29E-8 ID:SGTC_846|Compound:0335-0850|FD-Score:3.34|P-value:9.17E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.45|P-value:1.56E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:11.00|P-value:1.13E-25 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.45|P-value:6.38E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.58|P-value:4.97E-13 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.63|P-value:3.44E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.34|P-value:1.26E-9 ID:SGTC_1986|Compound:st071812|FD-Score:3.47|P-value:5.88E-4 ID:SGTC_1990|Compound:st072050|FD-Score:5.93|P-value:1.31E-8 ID:SGTC_1999|Compound:st074831|FD-Score:4.21|P-value:4.09E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.45|P-value:6.41E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.08|P-value:6.86E-5 ID:SGTC_2100|Compound:5377183|FD-Score:6.35|P-value:1.22E-9 ID:SGTC_2317|Compound:5986382|FD-Score:3.44|P-value:6.69E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.27|P-value:3.76E-7 ID:SGTC_2394|Compound:5221648|FD-Score:6.54|P-value:4.07E-10 ID:SGTC_2404|Compound:5161160|FD-Score:6.28|P-value:1.87E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.88|P-value:6.64E-21 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.51|P-value:3.84E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.56|P-value:9.87E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.61|P-value:3.73E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.81|P-value:3.35E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-4.00|P-value:6.37E-5 ID:SGTC_3147|Compound:9097027|FD-Score:4.20|P-value:4.27E-5 ID:SGTC_3350|Compound:9150499|FD-Score:4.68|P-value:5.68E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.77|P-value:1.51E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.72|P-value:4.06E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:11.90|P-value:1.84E-29 ID:SGTC_143|Compound:4032-1194|FD-Score:4.30|P-value:2.87E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.36|P-value:2.23E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.38|P-value:2.03E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.48|P-value:1.38E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.30|P-value:1.97E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:7.26|P-value:4.28E-12 ID:SGTC_375|Compound:3970-0961|FD-Score:3.50|P-value:5.40E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:8.54|P-value:4.79E-16 ID:SGTC_568|Compound:1193-0097|FD-Score:12.40|P-value:8.87E-32 ID:SGTC_733|Compound:4069-0007|FD-Score:6.05|P-value:6.82E-9 ID:SGTC_805|Compound:3852-0218|FD-Score:5.66|P-value:5.29E-8 ID:SGTC_846|Compound:0335-0850|FD-Score:3.34|P-value:9.17E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.45|P-value:1.56E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:11.00|P-value:1.13E-25 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.45|P-value:6.38E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.58|P-value:4.97E-13 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.63|P-value:3.44E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.34|P-value:1.26E-9 ID:SGTC_1986|Compound:st071812|FD-Score:3.47|P-value:5.88E-4 ID:SGTC_1990|Compound:st072050|FD-Score:5.93|P-value:1.31E-8 ID:SGTC_1999|Compound:st074831|FD-Score:4.21|P-value:4.09E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.45|P-value:6.41E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.08|P-value:6.86E-5 ID:SGTC_2100|Compound:5377183|FD-Score:6.35|P-value:1.22E-9 ID:SGTC_2317|Compound:5986382|FD-Score:3.44|P-value:6.69E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.27|P-value:3.76E-7 ID:SGTC_2394|Compound:5221648|FD-Score:6.54|P-value:4.07E-10 ID:SGTC_2404|Compound:5161160|FD-Score:6.28|P-value:1.87E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.88|P-value:6.64E-21 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.51|P-value:3.84E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.56|P-value:9.87E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.61|P-value:3.73E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.81|P-value:3.35E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-4.00|P-value:6.37E-5 ID:SGTC_3147|Compound:9097027|FD-Score:4.20|P-value:4.27E-5 ID:SGTC_3350|Compound:9150499|FD-Score:4.68|P-value:5.68E-6

Top fitness defect scores for YDR199W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 12.40 7.5 µM 8.87E-32 ERAD & cell cycle 12 1.62E-35
2 SGTC_103 0844-0104 11.90 51.8 µM 1.84E-29 ERAD & cell cycle 17 6.39E-33
3 SGTC_1026 k007-1105 11.00 30.6 µM 1.13E-25 ERAD & cell cycle 9 1.13E-28
4 SGTC_2582 agaric acid 9.88 100.0 µM 6.64E-21 redox potentiating 65 2.50E-23
5 SGTC_384 k007-0144 8.54 5.2 µM 4.79E-16 ERAD & cell cycle 12 6.99E-18
6 SGTC_1161 k007-0610 7.58 110.0 µM 4.97E-13 ERAD & cell cycle 28 1.69E-14
7 SGTC_373 0844-0104 7.26 25.9 µM 4.28E-12 ERAD & cell cycle 17 1.89E-13
8 SGTC_2394 5221648 6.54 200.0 µM 4.07E-10 2 3.13E-11
9 SGTC_2100 5377183 6.35 190.0 µM 1.22E-9 60S ribosome export 1 1.07E-10
10 SGTC_1785 bathophenanthroline 6.34 24.0 µM 1.26E-9 heme requiring 6 1.11E-10
11 SGTC_2404 5161160 6.28 200.0 µM 1.87E-9 3 1.73E-10
12 SGTC_733 4069-0007 6.05 56.1 µM 6.82E-9 ERAD & cell cycle 39 7.39E-10
13 SGTC_1990 st072050 5.93 59.8 µM 1.31E-8 2 1.53E-9
14 SGTC_64 000l-0018 5.72 272.1 µM 4.06E-8 ubiquinone biosynthesis & proteasome 85 5.46E-9
15 SGTC_805 3852-0218 5.66 479.0 µM 5.29E-8 ERAD & cell cycle 27 7.37E-9
16 SGTC_2322 7413319 5.27 38.2 µM 3.76E-7 ERAD & cell cycle 85 6.64E-8
17 SGTC_2942 9052777 4.81 62.2 µM 3.35E-6 13 7.73E-7
18 SGTC_3350 9150499 4.68 3.6 µM 5.68E-6 cell wall 31 1.40E-6
19 SGTC_2755 lomerizine 4.56 42.7 µM 9.87E-6 18 2.60E-6
20 SGTC_352 k048-0007 4.48 5.1 µM 1.38E-5 ERAD & cell cycle 62 3.80E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.538 5.54E-251 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.538 1.06E-250 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.517 1.28E-228 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.486 2.87E-198 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.454 5.26E-170 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.434 6.27E-154 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.416 7.30E-141 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.403 6.07E-131 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.399 1.34E-128 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.359 2.25E-102 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.357 1.02E-101 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.348 6.82E-96 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.344 1.50E-93 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.341 3.14E-92 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.334 3.84E-88 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses