YDR202C / RAV2

Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR202C / RAV2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.96|P-value:5.12E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:6.56|P-value:2.72E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:4.21|P-value:9.18E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:6.24|P-value:1.44E-8 ID:SGTC_263|Compound:alizarin|FD-Score:4.90|P-value:6.67E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.52|P-value:8.68E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.83|P-value:3.31E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.66|P-value:5.76E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.48|P-value:9.99E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:5.06|P-value:3.50E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:3.57|P-value:7.43E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.73|P-value:4.56E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.76|P-value:1.55E-7 ID:SGTC_917|Compound:harmaline|FD-Score:3.71|P-value:4.91E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.29|P-value:6.73E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.43|P-value:6.99E-7 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.47|P-value:3.51E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.51|P-value:3.01E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.63|P-value:1.95E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.57|P-value:7.63E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.74|P-value:4.43E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.44|P-value:3.96E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.88|P-value:2.91E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.97|P-value:2.10E-4 ID:SGTC_1687|Compound:st020778|FD-Score:9.65|P-value:5.05E-18 ID:SGTC_1694|Compound:st024011|FD-Score:3.54|P-value:8.21E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.42|P-value:4.31E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.70|P-value:1.51E-5 ID:SGTC_1761|Compound:st044296|FD-Score:4.09|P-value:1.36E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.53|P-value:8.61E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.90|P-value:2.69E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.55|P-value:2.62E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.49|P-value:9.50E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.24|P-value:8.26E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.66|P-value:5.71E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.82|P-value:3.43E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.59|P-value:3.42E-7 ID:SGTC_2291|Compound:7917025|FD-Score:11.00|P-value:6.12E-23 ID:SGTC_2322|Compound:7413319|FD-Score:5.02|P-value:4.13E-6 ID:SGTC_2389|Compound:9091542|FD-Score:3.74|P-value:4.41E-4 ID:SGTC_2426|Compound:5582046|FD-Score:5.13|P-value:2.59E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.52|P-value:8.72E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.99|P-value:4.62E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.05|P-value:1.60E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.05|P-value:1.57E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.12|P-value:1.24E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:9.22|P-value:1.24E-16 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.91|P-value:6.31E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.68|P-value:5.30E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.62|P-value:6.53E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.50|P-value:9.16E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.00|P-value:1.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.90|P-value:2.66E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.12|P-value:1.24E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.50|P-value:9.39E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.53|P-value:8.72E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.97|P-value:5.09E-6 ID:SGTC_2810|Compound:7959871|FD-Score:4.41|P-value:4.49E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.62|P-value:1.98E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.69|P-value:5.31E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.25|P-value:7.90E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.39|P-value:4.75E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-4.26|P-value:7.76E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.48|P-value:9.94E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-4.78|P-value:1.12E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.96|P-value:5.12E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:6.56|P-value:2.72E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:4.21|P-value:9.18E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:6.24|P-value:1.44E-8 ID:SGTC_263|Compound:alizarin|FD-Score:4.90|P-value:6.67E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.52|P-value:8.68E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.83|P-value:3.31E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.66|P-value:5.76E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.48|P-value:9.99E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:5.06|P-value:3.50E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:3.57|P-value:7.43E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.73|P-value:4.56E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:5.76|P-value:1.55E-7 ID:SGTC_917|Compound:harmaline|FD-Score:3.71|P-value:4.91E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.29|P-value:6.73E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.43|P-value:6.99E-7 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.47|P-value:3.51E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.51|P-value:3.01E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.63|P-value:1.95E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.57|P-value:7.63E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.74|P-value:4.43E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.44|P-value:3.96E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.88|P-value:2.91E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.97|P-value:2.10E-4 ID:SGTC_1687|Compound:st020778|FD-Score:9.65|P-value:5.05E-18 ID:SGTC_1694|Compound:st024011|FD-Score:3.54|P-value:8.21E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.42|P-value:4.31E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.70|P-value:1.51E-5 ID:SGTC_1761|Compound:st044296|FD-Score:4.09|P-value:1.36E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.53|P-value:8.61E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.90|P-value:2.69E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.55|P-value:2.62E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.49|P-value:9.50E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.24|P-value:8.26E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.66|P-value:5.71E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.82|P-value:3.43E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.59|P-value:3.42E-7 ID:SGTC_2291|Compound:7917025|FD-Score:11.00|P-value:6.12E-23 ID:SGTC_2322|Compound:7413319|FD-Score:5.02|P-value:4.13E-6 ID:SGTC_2389|Compound:9091542|FD-Score:3.74|P-value:4.41E-4 ID:SGTC_2426|Compound:5582046|FD-Score:5.13|P-value:2.59E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.52|P-value:8.72E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.99|P-value:4.62E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.05|P-value:1.60E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.05|P-value:1.57E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.12|P-value:1.24E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:9.22|P-value:1.24E-16 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.91|P-value:6.31E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.68|P-value:5.30E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.62|P-value:6.53E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.50|P-value:9.16E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.00|P-value:1.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.90|P-value:2.66E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.12|P-value:1.24E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.50|P-value:9.39E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.53|P-value:8.72E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.97|P-value:5.09E-6 ID:SGTC_2810|Compound:7959871|FD-Score:4.41|P-value:4.49E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.62|P-value:1.98E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.69|P-value:5.31E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.25|P-value:7.90E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.39|P-value:4.75E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-4.26|P-value:7.76E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.48|P-value:9.94E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-4.78|P-value:1.12E-5

Top fitness defect scores for YDR202C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2291 7917025 11.00 104.3 µM 6.12E-23 iron homeostasis 5 1.53E-28
2 SGTC_1687 st020778 9.65 55.4 µM 5.05E-18 53 2.51E-22
3 SGTC_2567 aureobasidin a 9.22 60.0 nM 1.24E-16 16 1.43E-20
4 SGTC_153 4077-0274 6.56 519.7 µM 2.72E-9 4 2.63E-11
5 SGTC_204 1543-0184 6.24 62.4 µM 1.44E-8 TRP & mitochondrial translation 10 2.14E-10
6 SGTC_841 0251-0215 5.76 91.2 µM 1.55E-7 39 4.28E-9
7 SGTC_2286 7945697 5.59 125.0 µM 3.42E-7 21 1.16E-8
8 SGTC_1040 k898-0338 5.43 155.0 µM 6.99E-7 6 2.84E-8
9 SGTC_2426 5582046 5.13 32.2 µM 2.59E-6 9 1.47E-7
10 SGTC_699 0375-0592 5.06 111.0 µM 3.50E-6 iron homeostasis 7 2.15E-7
11 SGTC_2322 7413319 5.02 38.2 µM 4.13E-6 ERAD & cell cycle 95 2.64E-7
12 SGTC_2507 purpurin 4.99 79.7 µM 4.62E-6 copper-dependent oxidative stress 19 3.04E-7
13 SGTC_10 0279-0212 4.96 42.6 µM 5.12E-6 TRP & mitochondrial translation 64 3.47E-7
14 SGTC_2575 plumbagin 4.91 510.0 nM 6.31E-6 superoxide 19 4.50E-7
15 SGTC_263 alizarin 4.90 107.9 µM 6.67E-6 iron homeostasis 36 4.82E-7
16 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.63 1.2 µM 1.95E-5 iron homeostasis 29 1.85E-6
17 SGTC_2896 9052656 4.62 71.4 µM 1.98E-5 endomembrane recycling 74 1.89E-6
18 SGTC_2021 4019055 4.55 173.0 µM 2.62E-5 endomembrane recycling 87 2.69E-6
19 SGTC_1063 disulfiram 4.51 1.8 µM 3.01E-5 13 3.20E-6
20 SGTC_1062 mesoridazine 4.47 14.2 µM 3.51E-5 11 3.86E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.367 1.80E-107 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.354 1.11E-99 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.299 3.05E-70 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.246 1.82E-47 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.212 1.46E-35 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.210 1.04E-34 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.205 3.06E-33 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.203 1.54E-32 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.202 3.69E-32 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.202 4.22E-32 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.200 1.50E-31 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.192 3.95E-29 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.188 6.02E-28 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.178 2.19E-25 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.166 4.10E-22 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress