YDR204W / COQ4

Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR204W / COQ4

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:19.30|P-value:3.50E-92 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.10|P-value:5.30E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:7.05|P-value:5.29E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:24.00|P-value:3.25E-141 ID:SGTC_67|Compound:0335-0847|FD-Score:15.80|P-value:3.33E-62 ID:SGTC_81|Compound:0411-0046|FD-Score:3.00|P-value:7.70E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:17.70|P-value:4.62E-78 ID:SGTC_87|Compound:0100-0052|FD-Score:6.29|P-value:1.65E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.71|P-value:2.13E-20 ID:SGTC_137|Compound:0438-0332|FD-Score:5.39|P-value:6.55E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:14.20|P-value:6.78E-51 ID:SGTC_149|Compound:3970-0822|FD-Score:3.05|P-value:6.46E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.02|P-value:1.13E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:18.80|P-value:4.12E-88 ID:SGTC_163|Compound:1327-0036|FD-Score:3.33|P-value:2.22E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.70|P-value:3.52E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:7.12|P-value:3.12E-14 ID:SGTC_195|Compound:4234-0266|FD-Score:3.13|P-value:4.89E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:9.59|P-value:2.48E-24 ID:SGTC_214|Compound:4373-3496|FD-Score:5.04|P-value:5.25E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:7.45|P-value:1.94E-15 ID:SGTC_230|Compound:MPP+|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:29.50|P-value:9.00E-213 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.12|P-value:4.93E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.05|P-value:9.88E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:6.61|P-value:1.56E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:5.51|P-value:3.14E-9 ID:SGTC_340|Compound:k038-0059|FD-Score:5.13|P-value:3.10E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:9.81|P-value:2.23E-25 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-4.42|P-value:1.61E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.98|P-value:1.35E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.75|P-value:3.81E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-2.97|P-value:8.94E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.53|P-value:9.89E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:3.36|P-value:1.96E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.88|P-value:1.37E-7 ID:SGTC_642|Compound:0335-0876|FD-Score:3.63|P-value:6.54E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.54|P-value:9.31E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.71|P-value:4.66E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:10.00|P-value:2.06E-26 ID:SGTC_824|Compound:1304-0008|FD-Score:4.38|P-value:1.92E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:7.05|P-value:5.17E-14 ID:SGTC_846|Compound:0335-0850|FD-Score:11.00|P-value:2.45E-31 ID:SGTC_866|Compound:0495-0101|FD-Score:-2.95|P-value:9.42E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.79|P-value:3.23E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.86|P-value:3.34E-10 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.08|P-value:5.77E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.02|P-value:7.15E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.94|P-value:9.56E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.32|P-value:2.65E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-2.99|P-value:8.26E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.04|P-value:6.83E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-3.26|P-value:2.99E-4 ID:SGTC_1635|Compound:st007035|FD-Score:13.90|P-value:5.94E-49 ID:SGTC_1676|Compound:st018489|FD-Score:4.39|P-value:1.85E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.60|P-value:7.52E-5 ID:SGTC_1765|Compound:st044815|FD-Score:2.95|P-value:9.18E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.88|P-value:1.37E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-5.03|P-value:5.99E-8 ID:SGTC_1802|Compound:st050112|FD-Score:3.45|P-value:1.35E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-5.52|P-value:3.07E-9 ID:SGTC_1893|Compound:st059353|FD-Score:3.61|P-value:6.98E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.34|P-value:2.20E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.69|P-value:3.75E-7 ID:SGTC_2361|Compound:9034121|FD-Score:3.09|P-value:5.68E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.43|P-value:1.47E-4 ID:SGTC_2441|Compound:5730946|FD-Score:2.97|P-value:8.60E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.68|P-value:5.32E-5 ID:SGTC_2457|Compound:5731572|FD-Score:2.94|P-value:9.76E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.44|P-value:1.47E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.05|P-value:9.81E-6 ID:SGTC_2987|Compound:9018338|FD-Score:-2.99|P-value:8.08E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.75|P-value:3.90E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.11|P-value:5.18E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.06|P-value:6.25E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.21|P-value:3.61E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:19.30|P-value:3.50E-92 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.10|P-value:5.30E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:7.05|P-value:5.29E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:24.00|P-value:3.25E-141 ID:SGTC_67|Compound:0335-0847|FD-Score:15.80|P-value:3.33E-62 ID:SGTC_81|Compound:0411-0046|FD-Score:3.00|P-value:7.70E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:17.70|P-value:4.62E-78 ID:SGTC_87|Compound:0100-0052|FD-Score:6.29|P-value:1.65E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.71|P-value:2.13E-20 ID:SGTC_137|Compound:0438-0332|FD-Score:5.39|P-value:6.55E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:14.20|P-value:6.78E-51 ID:SGTC_149|Compound:3970-0822|FD-Score:3.05|P-value:6.46E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.02|P-value:1.13E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:18.80|P-value:4.12E-88 ID:SGTC_163|Compound:1327-0036|FD-Score:3.33|P-value:2.22E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.70|P-value:3.52E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:7.12|P-value:3.12E-14 ID:SGTC_195|Compound:4234-0266|FD-Score:3.13|P-value:4.89E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:9.59|P-value:2.48E-24 ID:SGTC_214|Compound:4373-3496|FD-Score:5.04|P-value:5.25E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:7.45|P-value:1.94E-15 ID:SGTC_230|Compound:MPP+|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:29.50|P-value:9.00E-213 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.12|P-value:4.93E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.05|P-value:9.88E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:6.61|P-value:1.56E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:5.51|P-value:3.14E-9 ID:SGTC_340|Compound:k038-0059|FD-Score:5.13|P-value:3.10E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:9.81|P-value:2.23E-25 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-4.42|P-value:1.61E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.98|P-value:1.35E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.75|P-value:3.81E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-2.97|P-value:8.94E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.53|P-value:9.89E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:3.36|P-value:1.96E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.88|P-value:1.37E-7 ID:SGTC_642|Compound:0335-0876|FD-Score:3.63|P-value:6.54E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.54|P-value:9.31E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.71|P-value:4.66E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:10.00|P-value:2.06E-26 ID:SGTC_824|Compound:1304-0008|FD-Score:4.38|P-value:1.92E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:7.05|P-value:5.17E-14 ID:SGTC_846|Compound:0335-0850|FD-Score:11.00|P-value:2.45E-31 ID:SGTC_866|Compound:0495-0101|FD-Score:-2.95|P-value:9.42E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.79|P-value:3.23E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.86|P-value:3.34E-10 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.08|P-value:5.77E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.02|P-value:7.15E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.94|P-value:9.56E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.32|P-value:2.65E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-2.99|P-value:8.26E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.04|P-value:6.83E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-3.26|P-value:2.99E-4 ID:SGTC_1635|Compound:st007035|FD-Score:13.90|P-value:5.94E-49 ID:SGTC_1676|Compound:st018489|FD-Score:4.39|P-value:1.85E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.60|P-value:7.52E-5 ID:SGTC_1765|Compound:st044815|FD-Score:2.95|P-value:9.18E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.88|P-value:1.37E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-5.03|P-value:5.99E-8 ID:SGTC_1802|Compound:st050112|FD-Score:3.45|P-value:1.35E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-5.52|P-value:3.07E-9 ID:SGTC_1893|Compound:st059353|FD-Score:3.61|P-value:6.98E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.34|P-value:2.20E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.69|P-value:3.75E-7 ID:SGTC_2361|Compound:9034121|FD-Score:3.09|P-value:5.68E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.43|P-value:1.47E-4 ID:SGTC_2441|Compound:5730946|FD-Score:2.97|P-value:8.60E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.68|P-value:5.32E-5 ID:SGTC_2457|Compound:5731572|FD-Score:2.94|P-value:9.76E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.44|P-value:1.47E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.05|P-value:9.81E-6 ID:SGTC_2987|Compound:9018338|FD-Score:-2.99|P-value:8.08E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.75|P-value:3.90E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.11|P-value:5.18E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.06|P-value:6.25E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.21|P-value:3.61E-4

Top fitness defect scores for YDR204W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 29.50 5.3 µM 9.00E-213 16 8.26E-192
2 SGTC_64 000l-0018 24.00 272.1 µM 3.25E-141 ubiquinone biosynthesis & proteasome 5 2.28E-127
3 SGTC_36 0335-0881 19.30 14.2 µM 3.50E-92 ubiquinone biosynthesis & proteasome 4 3.28E-83
4 SGTC_158 k038-0087 18.80 26.4 µM 4.12E-88 ubiquinone biosynthesis & proteasome 7 1.52E-79
5 SGTC_86 0417-1630 17.70 471.9 µM 4.62E-78 ubiquinone biosynthesis & proteasome 7 1.72E-70
6 SGTC_67 0335-0847 15.80 266.0 µM 3.33E-62 ubiquinone biosynthesis & proteasome 8 3.29E-56
7 SGTC_142 0335-0849 14.20 62.7 µM 6.78E-51 ubiquinone biosynthesis & proteasome 18 5.06E-46
8 SGTC_1635 st007035 13.90 42.4 µM 5.94E-49 47 2.84E-44
9 SGTC_846 0335-0850 11.00 148.0 µM 2.45E-31 ubiquinone biosynthesis & proteasome 2 2.11E-28
10 SGTC_794 k038-0031 10.00 316.0 µM 2.06E-26 ubiquinone biosynthesis & proteasome 18 5.77E-24
11 SGTC_386 1509-0011 9.81 3.1 µM 2.23E-25 48 4.93E-23
12 SGTC_200 k038-0079 9.59 37.5 µM 2.48E-24 ubiquinone biosynthesis & proteasome 8 4.32E-22
13 SGTC_134 0269-0018 8.71 6.9 µM 2.13E-20 50 1.52E-18
14 SGTC_216 k038-0035 7.45 28.4 µM 1.94E-15 ubiquinone biosynthesis & proteasome 13 4.49E-14
15 SGTC_168 3970-0862 7.12 530.5 µM 3.12E-14 27 5.50E-13
16 SGTC_837 0091-0265 7.05 12.5 µM 5.17E-14 ubiquinone biosynthesis & proteasome 8 8.67E-13
17 SGTC_59 0330-0160 7.05 1.3 µM 5.29E-14 20 8.85E-13
18 SGTC_294 k038-0071 6.61 157.0 µM 1.56E-12 ubiquinone biosynthesis & proteasome 9 1.88E-11
19 SGTC_87 0100-0052 6.29 35.5 µM 1.65E-11 27 1.58E-10
20 SGTC_908 3448-7491 5.86 47.7 µM 3.34E-10 mitochondrial stress 53 2.37E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.848 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.829 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.802 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.799 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.787 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.750 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.703 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.670 0 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.644 0 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.634 0 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.593 1.75E-318 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.573 1.40E-291 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.557 1.85E-273 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.557 3.81E-273 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.538 1.04E-250 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes