YDR205W / MSC2

Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR205W / MSC2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:29.80|P-value:1.93E-178 ID:SGTC_138|Compound:0850-0259|FD-Score:6.00|P-value:4.94E-9 ID:SGTC_304|Compound:1310-0298|FD-Score:4.00|P-value:6.49E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.30|P-value:8.72E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.29|P-value:9.16E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.86|P-value:1.09E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.23|P-value:2.58E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.31|P-value:7.60E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.55|P-value:3.43E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-6.60|P-value:1.73E-10 ID:SGTC_814|Compound:3342-0569|FD-Score:4.89|P-value:1.44E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.42|P-value:5.32E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:5.45|P-value:9.37E-8 ID:SGTC_953|Compound:1188-0045|FD-Score:3.61|P-value:2.76E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.41|P-value:5.46E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.99|P-value:6.74E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.34|P-value:1.68E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:5.82|P-value:1.35E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:-5.76|P-value:2.20E-8 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.28|P-value:8.35E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.04|P-value:5.58E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.24|P-value:9.57E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.32|P-value:8.35E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.85|P-value:1.15E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:6.83|P-value:3.50E-11 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.25|P-value:2.68E-5 ID:SGTC_1941|Compound:st076221|FD-Score:5.80|P-value:1.46E-8 ID:SGTC_1945|Compound:st075991|FD-Score:3.99|P-value:6.81E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.84|P-value:1.18E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.63|P-value:2.55E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.46|P-value:5.08E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.43|P-value:1.07E-7 ID:SGTC_2432|Compound:5630864|FD-Score:3.23|P-value:9.91E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.28|P-value:2.12E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.25|P-value:9.28E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.58|P-value:3.07E-4 ID:SGTC_2702|Compound:st077768|FD-Score:5.59|P-value:4.63E-8 ID:SGTC_2781|Compound:5567276|FD-Score:-4.43|P-value:1.28E-5 ID:SGTC_2791|Compound:5663188|FD-Score:6.62|P-value:1.31E-10 ID:SGTC_2815|Compound:7968870|FD-Score:3.58|P-value:3.01E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.38|P-value:5.98E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.28|P-value:8.51E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.38|P-value:6.12E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.88|P-value:1.01E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.27|P-value:9.79E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-5.15|P-value:4.91E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:29.80|P-value:1.93E-178 ID:SGTC_138|Compound:0850-0259|FD-Score:6.00|P-value:4.94E-9 ID:SGTC_304|Compound:1310-0298|FD-Score:4.00|P-value:6.49E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.30|P-value:8.72E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.29|P-value:9.16E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.86|P-value:1.09E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.23|P-value:2.58E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.31|P-value:7.60E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.55|P-value:3.43E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-6.60|P-value:1.73E-10 ID:SGTC_814|Compound:3342-0569|FD-Score:4.89|P-value:1.44E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.42|P-value:5.32E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:5.45|P-value:9.37E-8 ID:SGTC_953|Compound:1188-0045|FD-Score:3.61|P-value:2.76E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.41|P-value:5.46E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.99|P-value:6.74E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.34|P-value:1.68E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:5.82|P-value:1.35E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:-5.76|P-value:2.20E-8 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.28|P-value:8.35E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.04|P-value:5.58E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.24|P-value:9.57E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.32|P-value:8.35E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.85|P-value:1.15E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:6.83|P-value:3.50E-11 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.25|P-value:2.68E-5 ID:SGTC_1941|Compound:st076221|FD-Score:5.80|P-value:1.46E-8 ID:SGTC_1945|Compound:st075991|FD-Score:3.99|P-value:6.81E-5 ID:SGTC_2094|Compound:5332512|FD-Score:3.84|P-value:1.18E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.63|P-value:2.55E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.46|P-value:5.08E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.43|P-value:1.07E-7 ID:SGTC_2432|Compound:5630864|FD-Score:3.23|P-value:9.91E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.28|P-value:2.12E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.25|P-value:9.28E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.58|P-value:3.07E-4 ID:SGTC_2702|Compound:st077768|FD-Score:5.59|P-value:4.63E-8 ID:SGTC_2781|Compound:5567276|FD-Score:-4.43|P-value:1.28E-5 ID:SGTC_2791|Compound:5663188|FD-Score:6.62|P-value:1.31E-10 ID:SGTC_2815|Compound:7968870|FD-Score:3.58|P-value:3.01E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.38|P-value:5.98E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.28|P-value:8.51E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.38|P-value:6.12E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.88|P-value:1.01E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.27|P-value:9.79E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-5.15|P-value:4.91E-7

Top fitness defect scores for YDR205W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 29.80 9.0 µM 1.93E-178 cell wall 1 4.66E-196
2 SGTC_1888 azatryptophan 6.83 97.5 µM 3.50E-11 3 4.34E-12
3 SGTC_2791 5663188 6.62 71.4 µM 1.31E-10 RPP1 & pyrimidine depletion 1 1.85E-11
4 SGTC_138 0850-0259 6.00 40.9 µM 4.94E-9 cell wall 106 9.88E-10
5 SGTC_1384 3089-0840 5.82 101.0 µM 1.35E-8 5 2.97E-9
6 SGTC_1941 st076221 5.80 61.8 µM 1.46E-8 sphingolipid biosynthesis & PDR1 33 3.23E-9
7 SGTC_2702 st077768 5.59 96.8 µM 4.63E-8 5 1.15E-8
8 SGTC_942 3253-1115 5.45 227.0 µM 9.37E-8 6 2.48E-8
9 SGTC_2397 5161689 5.43 200.0 µM 1.07E-7 9 2.88E-8
10 SGTC_814 3342-0569 4.89 96.0 µM 1.44E-6 10 4.94E-7
11 SGTC_1345 1488-0192 4.34 31.4 µM 1.68E-5 12 7.24E-6
12 SGTC_2454 5-benzylidenerhodanine 4.28 10.4 µM 2.12E-5 TRP & mitochondrial translation 27 9.34E-6
13 SGTC_562 3772-2733 4.23 112.0 µM 2.58E-5 ERG2 71 1.16E-5
14 SGTC_1604 st002052 4.04 72.4 µM 5.58E-5 TSC3-RPN4 26 2.69E-5
15 SGTC_304 1310-0298 4.00 97.0 µM 6.49E-5 cell wall 60 3.17E-5
16 SGTC_1250 0485-0349 3.99 40.2 µM 6.74E-5 34 3.30E-5
17 SGTC_1945 st075991 3.99 56.6 µM 6.81E-5 60S ribosome export 17 3.34E-5
18 SGTC_3067 9117431 3.88 49.5 µM 1.01E-4 12 5.15E-5
19 SGTC_552 k242-0005 3.86 476.0 µM 1.09E-4 17 5.59E-5
20 SGTC_1876 myriocin 3.85 605.0 nM 1.15E-4 38 5.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.441 1.86E-159 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.429 3.00E-150 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.425 5.09E-147 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.400 5.77E-129 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.394 3.95E-125 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.389 7.86E-122 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.388 1.52E-120 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.384 3.72E-118 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.377 1.73E-113 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.359 1.66E-102 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.358 3.40E-102 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.348 5.99E-96 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.347 1.56E-95 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.342 7.81E-93 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.338 3.81E-90 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together