YDR210W_p

Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR210W / YDR210W

Click on Significant Values for Screen Details ID:SGTC_527|Compound:4476-4215|FD-Score:-2.77|P-value:7.50E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.41|P-value:2.78E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.59|P-value:1.85E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.15|P-value:1.47E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.73|P-value:5.36E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.38|P-value:1.34E-10 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.79|P-value:8.51E-16 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.72|P-value:6.34E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.70|P-value:9.82E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.21|P-value:7.58E-5 ID:SGTC_2125|Compound:5246583|FD-Score:2.61|P-value:9.83E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.27|P-value:2.41E-7 ID:SGTC_2293|Compound:7624732|FD-Score:-4.54|P-value:8.29E-8 ID:SGTC_2363|Compound:9053361|FD-Score:2.72|P-value:6.39E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.71|P-value:6.16E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.19|P-value:8.07E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.81|P-value:3.48E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-2.79|P-value:7.07E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.77|P-value:7.50E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.41|P-value:2.78E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.59|P-value:1.85E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.15|P-value:1.47E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.73|P-value:5.36E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.38|P-value:1.34E-10 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.79|P-value:8.51E-16 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.72|P-value:6.34E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.70|P-value:9.82E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.21|P-value:7.58E-5 ID:SGTC_2125|Compound:5246583|FD-Score:2.61|P-value:9.83E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.27|P-value:2.41E-7 ID:SGTC_2293|Compound:7624732|FD-Score:-4.54|P-value:8.29E-8 ID:SGTC_2363|Compound:9053361|FD-Score:2.72|P-value:6.39E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.71|P-value:6.16E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.19|P-value:8.07E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.81|P-value:3.48E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-2.79|P-value:7.07E-4

Top fitness defect scores for YDR210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 6.79 265.0 µM 8.51E-16 4 5.70E-12
2 SGTC_1248 0469-0687 5.38 58.6 µM 1.34E-10 5 3.81E-8
3 SGTC_2288 7946289 4.27 167.3 µM 2.41E-7 19 9.60E-6
4 SGTC_2794 7785382 3.81 27.3 µM 3.48E-6 41 6.89E-5
5 SGTC_1246 0422-0085 3.73 105.0 µM 5.36E-6 38 9.49E-5
6 SGTC_2407 paclitaxel 3.71 400.0 µM 6.16E-6 46 1.05E-4
7 SGTC_716 1683-5115 3.41 658.0 µM 2.78E-5 39 3.21E-4
8 SGTC_1923 st058458 3.21 19.1 µM 7.58E-5 67 6.74E-4
9 SGTC_2693 st077581 3.19 40.7 µM 8.07E-5 74 7.06E-4
10 SGTC_1270 0831-1170 2.72 17.3 µM 6.34E-4 76 0.00326
11 SGTC_2363 9053361 2.72 176.0 µM 6.39E-4 Golgi 102 0.00328
12 SGTC_2125 5246583 2.61 200.0 µM 9.83E-4 tubulin folding & SWR complex 136 0.00452
13 SGTC_2284 7945075 2.53 39.2 µM 0.00132 mitochondrial processes 123 0.00565
14 SGTC_3315 9136395 2.52 68.5 µM 0.00141 101 0.00592
15 SGTC_1343 1487-0095 2.46 224.0 µM 0.00177 91 0.00702
16 SGTC_2220 6782180 2.44 200.0 µM 0.00188 RNA processing & uracil transport 54 0.00733
17 SGTC_1924 st058459 2.40 75.1 µM 0.00219 97 0.00821
18 SGTC_2167 5876490 2.38 200.0 µM 0.00236 156 0.00869
19 SGTC_790 1575-0012 2.34 79.1 µM 0.00271 TSC3-RPN4 156 0.00964
20 SGTC_1242 0402-0103 2.33 60.1 µM 0.00283 129 0.00995

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 2.48E-45 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.211 4.31E-35 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.204 5.72E-33 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.197 1.05E-30 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.197 1.46E-30 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.194 6.87E-30 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.189 2.95E-28 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.186 1.84E-27 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.186 2.23E-27 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.185 3.13E-27 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.181 3.83E-26 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.179 1.44E-25 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.178 3.20E-25 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.168 1.02E-22 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.165 7.04E-22 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41