YDR215C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR215C / YDR215C

Click on Significant Values for Screen Details ID:SGTC_271|Compound:rotenone|FD-Score:-3.30|P-value:3.56E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.31|P-value:6.15E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.15|P-value:6.28E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.42|P-value:2.30E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.09|P-value:7.60E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.07|P-value:8.13E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.30|P-value:3.61E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.75|P-value:6.03E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.04|P-value:2.03E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.06|P-value:8.56E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.05|P-value:9.94E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.14|P-value:1.15E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.20|P-value:5.96E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.29|P-value:4.26E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.38|P-value:2.72E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-5.09|P-value:9.90E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:4.55|P-value:1.93E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.74|P-value:6.49E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-3.61|P-value:1.07E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.42|P-value:2.60E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.88|P-value:3.67E-7 ID:SGTC_271|Compound:rotenone|FD-Score:-3.30|P-value:3.56E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.31|P-value:6.15E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.15|P-value:6.28E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.42|P-value:2.30E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.66|P-value:1.01E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.09|P-value:7.60E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.07|P-value:8.13E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.30|P-value:3.61E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.75|P-value:6.03E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:4.04|P-value:2.03E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.06|P-value:8.56E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.05|P-value:9.94E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.14|P-value:1.15E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.20|P-value:5.96E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.29|P-value:4.26E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.38|P-value:2.72E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-5.09|P-value:9.90E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:4.55|P-value:1.93E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.74|P-value:6.49E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-3.61|P-value:1.07E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.42|P-value:2.60E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.88|P-value:3.67E-7

Top fitness defect scores for YDR215C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3143 9086658 4.88 49.5 µM 3.67E-7 19 5.42E-7
2 SGTC_2610 ononetin 4.55 44.2 µM 1.93E-6 24 2.71E-6
3 SGTC_504 lovastatin 4.31 124.0 µM 6.15E-6 8 8.28E-6
4 SGTC_1349 flufenamic acid 4.04 69.0 µM 2.03E-5 10 2.63E-5
5 SGTC_792 4534-1957 3.66 155.0 µM 1.01E-4 47 1.25E-4
6 SGTC_3141 9094609 3.42 49.5 µM 2.60E-4 iron homeostasis 53 3.11E-4
7 SGTC_2036 5160441 3.29 105.0 µM 4.26E-4 NEO1 107 5.02E-4
8 SGTC_1842 st055362 3.20 61.2 µM 5.96E-4 37 6.96E-4
9 SGTC_1348 1493-0373 3.16 93.8 µM 6.78E-4 40 7.87E-4
10 SGTC_1412 3909-8563 3.05 178.0 µM 9.94E-4 41 0.00114
11 SGTC_1870 st057514 3.05 26.5 µM 0.00101 RSC & ERG11 59 0.00115
12 SGTC_749 1000-0129 2.91 128.0 µM 0.00157 amide catabolism 72 0.00178
13 SGTC_783 0848-0141 2.91 92.7 µM 0.00160 RSC & ERG11 53 0.00182
14 SGTC_1057 3448-5381 2.86 134.0 µM 0.00186 calcium & mitochondrial duress 76 0.00210
15 SGTC_1957 st077035 2.85 62.4 µM 0.00197 59 0.00222
16 SGTC_921 1561-0023 2.84 372.0 µM 0.00200 70 0.00225
17 SGTC_1356 1502-0781 2.82 85.8 µM 0.00215 fatty acid desaturase (OLE1) 72 0.00241
18 SGTC_1741 st038134 2.80 10.2 µM 0.00229 94 0.00257
19 SGTC_1753 st043925 2.70 64.0 µM 0.00316 61 0.00351
20 SGTC_776 4476-4378 2.68 112.0 µM 0.00337 ERG2 87 0.00374

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.18E-25 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.133 1.02E-14 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.123 9.83E-13 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.41E-12 YKL085W MDH1 hom Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
0.117 1.11E-11 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.113 5.33E-11 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.113 6.26E-11 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.112 8.89E-11 YBR146W MRPS9 hom Mitochondrial ribosomal protein of the small subunit
0.111 1.11E-10 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.100 7.06E-9 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.099 1.05E-8 YGL215W CLG1 hom Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.097 1.59E-8 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.097 1.86E-8 YHR048W_p YHK8_p hom Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
0.095 3.65E-8 YDL109C_p YDL109C_p hom Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
0.095 4.15E-8 YPR183W DPM1 het Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation