HIPHOP chemogenomics database
YDR215C_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR215C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.179 | 1.18E-25 | YDR051C | DET1 | hom | Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel |
| 0.133 | 1.02E-14 | YJR152W | DAL5 | hom | Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression |
| 0.123 | 9.83E-13 | YJL007C_d | YJL007C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.122 | 1.41E-12 | YKL085W | MDH1 | hom | Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated |
| 0.117 | 1.11E-11 | YOR219C | STE13 | hom | Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor |
| 0.113 | 5.33E-11 | YKL184W | SPE1 | hom | Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation |
| 0.113 | 6.26E-11 | YLR136C | TIS11 | hom | mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress |
| 0.112 | 8.89E-11 | YBR146W | MRPS9 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.111 | 1.11E-10 | YPR082C | DIB1 | het | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
| 0.100 | 7.06E-9 | YKL021C | MAK11 | het | Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats |
| 0.099 | 1.05E-8 | YGL215W | CLG1 | hom | Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 |
| 0.097 | 1.59E-8 | YMR288W | HSH155 | het | U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 |
| 0.097 | 1.86E-8 | YHR048W_p | YHK8_p | hom | Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles |
| 0.095 | 3.65E-8 | YDL109C_p | YDL109C_p | hom | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication |
| 0.095 | 4.15E-8 | YPR183W | DPM1 | het | Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation |