YDR231C / COX20

Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR231C / COX20

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.34|P-value:4.45E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.21|P-value:2.93E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.27|P-value:7.35E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:3.40|P-value:3.56E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.61|P-value:2.20E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:8.27E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:24.60|P-value:2.67E-133 ID:SGTC_149|Compound:3970-0822|FD-Score:7.42|P-value:7.11E-14 ID:SGTC_150|Compound:3970-0969|FD-Score:8.03|P-value:6.12E-16 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.83|P-value:2.88E-9 ID:SGTC_157|Compound:1348-1695|FD-Score:4.06|P-value:2.59E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.88|P-value:5.78E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.39|P-value:3.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:22.70|P-value:7.72E-114 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.47|P-value:2.44E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:3.91|P-value:4.86E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:3.56|P-value:1.96E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.29|P-value:5.16E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:16.90|P-value:3.53E-64 ID:SGTC_394|Compound:menadione|FD-Score:-3.22|P-value:6.59E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.30|P-value:9.16E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.18|P-value:7.34E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.35|P-value:4.05E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.42|P-value:3.17E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.93|P-value:4.56E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.30|P-value:5.00E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.55|P-value:2.73E-6 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.55|P-value:2.01E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.71|P-value:1.07E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.27|P-value:5.41E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.33|P-value:4.43E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.70|P-value:5.92E-37 ID:SGTC_1731|Compound:st035964|FD-Score:-3.30|P-value:4.99E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.67|P-value:1.22E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.23|P-value:6.27E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.16|P-value:7.87E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.65|P-value:1.39E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.68|P-value:1.20E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-4.84|P-value:6.67E-7 ID:SGTC_2077|Compound:5212015|FD-Score:-3.33|P-value:4.35E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.22|P-value:6.74E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.57|P-value:1.89E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.35|P-value:4.27E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.17|P-value:7.86E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.97|P-value:3.85E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.59|P-value:1.75E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.42|P-value:3.15E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.34|P-value:4.45E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.21|P-value:2.93E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.27|P-value:7.35E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:3.40|P-value:3.56E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.61|P-value:2.20E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:8.27E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:24.60|P-value:2.67E-133 ID:SGTC_149|Compound:3970-0822|FD-Score:7.42|P-value:7.11E-14 ID:SGTC_150|Compound:3970-0969|FD-Score:8.03|P-value:6.12E-16 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.83|P-value:2.88E-9 ID:SGTC_157|Compound:1348-1695|FD-Score:4.06|P-value:2.59E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.88|P-value:5.78E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.39|P-value:3.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:22.70|P-value:7.72E-114 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.47|P-value:2.44E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:3.91|P-value:4.86E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:3.56|P-value:1.96E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.29|P-value:5.16E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:16.90|P-value:3.53E-64 ID:SGTC_394|Compound:menadione|FD-Score:-3.22|P-value:6.59E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.30|P-value:9.16E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.18|P-value:7.34E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.35|P-value:4.05E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.42|P-value:3.17E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.93|P-value:4.56E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.30|P-value:5.00E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.55|P-value:2.73E-6 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.55|P-value:2.01E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.71|P-value:1.07E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:-3.27|P-value:5.41E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.33|P-value:4.43E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.70|P-value:5.92E-37 ID:SGTC_1731|Compound:st035964|FD-Score:-3.30|P-value:4.99E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.67|P-value:1.22E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.23|P-value:6.27E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.16|P-value:7.87E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.65|P-value:1.39E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.68|P-value:1.20E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-4.84|P-value:6.67E-7 ID:SGTC_2077|Compound:5212015|FD-Score:-3.33|P-value:4.35E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.22|P-value:6.74E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.57|P-value:1.89E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.35|P-value:4.27E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.17|P-value:7.86E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.97|P-value:3.85E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.59|P-value:1.75E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.42|P-value:3.15E-4

Top fitness defect scores for YDR231C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 24.60 6.9 µM 2.67E-133 1 5.65E-134
2 SGTC_236 1509-0011 22.70 5.3 µM 7.72E-114 41 2.05E-114
3 SGTC_386 1509-0011 16.90 3.1 µM 3.53E-64 16 1.66E-64
4 SGTC_1635 st007035 12.70 42.4 µM 5.92E-37 52 3.81E-37
5 SGTC_150 3970-0969 8.03 77.2 µM 6.12E-16 7 5.06E-16
6 SGTC_149 3970-0822 7.42 46.1 µM 7.11E-14 tubulin folding & SWR complex 17 6.03E-14
7 SGTC_59 0330-0160 6.21 1.3 µM 2.93E-10 33 2.59E-10
8 SGTC_275 trichlorophene 5.47 5.7 µM 2.44E-8 mitochondrial stress 140 2.21E-8
9 SGTC_87 0100-0052 5.27 35.5 µM 7.35E-8 46 6.71E-8
10 SGTC_119 0121-0043 5.25 24.8 µM 8.27E-8 mitochondrial stress 46 7.55E-8
11 SGTC_168 3970-0862 4.88 530.5 µM 5.78E-7 74 5.34E-7
12 SGTC_118 0083-0097 4.61 135.3 µM 2.20E-6 translation 80 2.04E-6
13 SGTC_533 1222-0222 4.30 6.7 µM 9.16E-6 PDR1 23 8.59E-6
14 SGTC_157 1348-1695 4.06 65.8 µM 2.59E-5 iron homeostasis 67 2.44E-5
15 SGTC_3094 9117742 3.97 49.5 µM 3.85E-5 19 3.63E-5
16 SGTC_1133 3473-0247 3.93 50.0 µM 4.56E-5 RSC complex & mRNA processing 50 4.31E-5
17 SGTC_310 1273-0058 3.91 1.1 µM 4.86E-5 mitochondrial stress 247 4.60E-5
18 SGTC_495 decylubiquinone 3.72 155.0 µM 1.06E-4 copper-dependent oxidative stress 30 1.00E-4
19 SGTC_1511 0906-3109 3.71 28.5 µM 1.07E-4 excess fatty acid 59 1.02E-4
20 SGTC_1948 st076329 3.68 66.6 µM 1.20E-4 39 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.750 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.705 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.682 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.677 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.673 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.666 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.662 0 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.657 0 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.654 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.651 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.651 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.649 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.646 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.645 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.642 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases