YDR242W / AMD2

Putative amidase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR242W / AMD2

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:2.78|P-value:5.27E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.19|P-value:8.75E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:-2.86|P-value:6.14E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.83|P-value:6.97E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.76|P-value:9.12E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.36|P-value:1.80E-17 ID:SGTC_886|Compound:0866-0150|FD-Score:3.17|P-value:9.45E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:2.66|P-value:8.24E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.79|P-value:4.89E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.02|P-value:1.88E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.92|P-value:2.84E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.13|P-value:1.15E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.24|P-value:1.20E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.35|P-value:1.71E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.80|P-value:4.09E-6 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.63|P-value:9.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.20|P-value:1.54E-9 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.91|P-value:3.03E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.09|P-value:1.39E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.95|P-value:1.81E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-2.98|P-value:3.76E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.54|P-value:3.04E-5 ID:SGTC_1799|Compound:st045822|FD-Score:2.62|P-value:9.83E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.77|P-value:8.77E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.94|P-value:2.67E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.37|P-value:3.28E-7 ID:SGTC_2080|Compound:5212524|FD-Score:2.64|P-value:9.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.27|P-value:1.07E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.92|P-value:2.84E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.17|P-value:1.68E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.98|P-value:3.77E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.30|P-value:5.13E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.09|P-value:1.71E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.29|P-value:9.67E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.47|P-value:4.12E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.78|P-value:5.27E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.19|P-value:8.75E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:-2.86|P-value:6.14E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.83|P-value:6.97E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.76|P-value:9.12E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.36|P-value:1.80E-17 ID:SGTC_886|Compound:0866-0150|FD-Score:3.17|P-value:9.45E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:2.66|P-value:8.24E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.79|P-value:4.89E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.02|P-value:1.88E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.92|P-value:2.84E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.13|P-value:1.15E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.24|P-value:1.20E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.35|P-value:1.71E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.80|P-value:4.09E-6 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.63|P-value:9.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.20|P-value:1.54E-9 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.91|P-value:3.03E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.09|P-value:1.39E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.95|P-value:1.81E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-2.98|P-value:3.76E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.54|P-value:3.04E-5 ID:SGTC_1799|Compound:st045822|FD-Score:2.62|P-value:9.83E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.77|P-value:8.77E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.94|P-value:2.67E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.37|P-value:3.28E-7 ID:SGTC_2080|Compound:5212524|FD-Score:2.64|P-value:9.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.27|P-value:1.07E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.92|P-value:2.84E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.17|P-value:1.68E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.98|P-value:3.77E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.30|P-value:5.13E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-4.09|P-value:1.71E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.29|P-value:9.67E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.47|P-value:4.12E-5

Top fitness defect scores for YDR242W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 4.35 1.8 µM 1.71E-7 70 6.66E-6
2 SGTC_1620 st003704 3.95 16.5 µM 1.81E-6 16 3.90E-5
3 SGTC_1003 4049-0218 3.80 100.0 µM 4.09E-6 23 7.18E-5
4 SGTC_2625 euphol 3.30 100.0 µM 5.13E-5 59 4.79E-4
5 SGTC_284 0988-0104 3.19 32.6 µM 8.75E-5 heme requiring 29 7.15E-4
6 SGTC_886 0866-0150 3.17 153.0 µM 9.45E-5 54 7.58E-4
7 SGTC_994 3910-0338 3.13 138.0 µM 1.15E-4 calcium & mitochondrial duress 87 8.78E-4
8 SGTC_1618 st003135 3.09 44.5 µM 1.39E-4 43 0.00101
9 SGTC_940 3232-1287 3.02 54.8 µM 1.88E-4 NEO1 82 0.00127
10 SGTC_1924 st058459 2.94 75.1 µM 2.67E-4 46 0.00165
11 SGTC_2374 9071832 2.92 200.0 µM 2.84E-4 endomembrane recycling 38 0.00173
12 SGTC_968 1309-0633 2.92 340.0 µM 2.84E-4 54 0.00173
13 SGTC_1270 0831-1170 2.91 17.3 µM 3.03E-4 55 0.00182
14 SGTC_938 3126-1755 2.79 342.0 µM 4.89E-4 58 0.00261
15 SGTC_182 3448-4371 2.78 550.5 µM 5.27E-4 82 0.00276
16 SGTC_916 4466-0038 2.66 42.0 nM 8.24E-4 cell wall 184 0.00386
17 SGTC_2080 5212524 2.64 12.4 µM 9.18E-4 copper-dependent oxidative stress 71 0.00419
18 SGTC_1008 4106-0037 2.63 6.0 µM 9.37E-4 PDR1 74 0.00425
19 SGTC_1799 st045822 2.62 46.1 µM 9.83E-4 80 0.00441
20 SGTC_3214 9129694 2.57 49.5 µM 0.00118 111 0.00505

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 1.64E-55 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.266 5.33E-55 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.250 1.22E-48 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.248 3.02E-48 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.248 3.37E-48 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.248 6.21E-48 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.245 8.35E-47 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.231 7.36E-42 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.229 5.54E-41 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.222 9.82E-39 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.222 1.14E-38 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.222 1.80E-38 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.221 2.45E-38 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.212 2.60E-35 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.212 3.22E-35 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS