YDR244W / PEX5

Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR244W / PEX5

Click on Significant Values for Screen Details ID:SGTC_335|Compound:4077-0256|FD-Score:-4.47|P-value:2.21E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.93|P-value:1.70E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.76|P-value:2.93E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.65|P-value:1.05E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.87|P-value:2.10E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.59|P-value:5.09E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.38|P-value:3.14E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.97|P-value:1.44E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.49|P-value:7.03E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.47|P-value:7.93E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.89|P-value:1.89E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.74|P-value:3.30E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.53|P-value:6.26E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.50|P-value:6.83E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.40|P-value:9.69E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.84|P-value:2.26E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.25|P-value:5.42E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-4.61|P-value:1.26E-5 ID:SGTC_2469|Compound:5655019|FD-Score:-3.41|P-value:8.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.54|P-value:6.19E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.51|P-value:6.68E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.12|P-value:8.76E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.62|P-value:4.79E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.43|P-value:8.67E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-4.16|P-value:7.20E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.47|P-value:2.21E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.93|P-value:1.70E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.76|P-value:2.93E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-4.65|P-value:1.05E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.87|P-value:2.10E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.59|P-value:5.09E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.38|P-value:3.14E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.97|P-value:1.44E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.49|P-value:7.03E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.47|P-value:7.93E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.89|P-value:1.89E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.74|P-value:3.30E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.53|P-value:6.26E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.50|P-value:6.83E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.40|P-value:9.69E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.84|P-value:2.26E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.25|P-value:5.42E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-4.61|P-value:1.26E-5 ID:SGTC_2469|Compound:5655019|FD-Score:-3.41|P-value:8.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.54|P-value:6.19E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.51|P-value:6.68E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.12|P-value:8.76E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.62|P-value:4.79E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.43|P-value:8.67E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-4.16|P-value:7.20E-5

Top fitness defect scores for YDR244W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2018 5133068 4.25 143.0 µM 5.42E-5 16 1.09E-5
2 SGTC_2805 7950783 4.12 58.4 µM 8.76E-5 27 1.93E-5
3 SGTC_358 0075-0058 3.93 9.4 µM 1.70E-4 63 4.24E-5
4 SGTC_636 0kpi-0074 3.87 126.0 µM 2.10E-4 21 5.46E-5
5 SGTC_1437 4092-1038 3.74 11.6 µM 3.30E-4 21 9.34E-5
6 SGTC_2929 9013348 3.62 24.6 µM 4.79E-4 35 1.46E-4
7 SGTC_2582 agaric acid 3.54 100.0 µM 6.19E-4 redox potentiating 362 1.97E-4
8 SGTC_1282 0886-0010 3.47 32.4 µM 7.93E-4 endomembrane recycling 48 2.65E-4
9 SGTC_1743 st037606 3.40 46.4 µM 9.69E-4 38 3.36E-4
10 SGTC_1887 st057648 3.37 70.8 µM 0.00106 30 3.73E-4
11 SGTC_3304 9125678 3.37 46.1 µM 0.00106 80 3.75E-4
12 SGTC_1905 st060207 3.37 84.5 µM 0.00107 22 3.77E-4
13 SGTC_2930 9013230 3.36 14.9 µM 0.00109 heme biosynthesis & mitochondrial translocase 63 3.85E-4
14 SGTC_2023 5144124 3.34 124.0 µM 0.00117 40 4.18E-4
15 SGTC_624 k048-0052 3.25 28.0 µM 0.00151 Golgi 35 5.69E-4
16 SGTC_1718 roemerine 3.24 11.9 µM 0.00156 redox potentiating 94 5.91E-4
17 SGTC_2279 7948423 3.19 32.9 µM 0.00181 33 7.07E-4
18 SGTC_2857 9024691 3.11 58.4 µM 0.00232 64 9.46E-4
19 SGTC_2390 9097792 3.08 176.6 µM 0.00248 49 0.00103
20 SGTC_2016 5121758 3.07 140.0 µM 0.00256 redox potentiating 101 0.00106

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.11E-18 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.149 5.13E-18 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.143 9.32E-17 YPL274W SAM3 hom High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.137 1.67E-15 YKR071C DRE2 het Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
0.135 3.71E-15 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.128 9.97E-14 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.127 1.81E-13 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.119 3.93E-12 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.116 1.32E-11 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.113 5.21E-11 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.111 1.12E-10 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.110 1.61E-10 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.109 2.23E-10 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.108 2.96E-10 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.108 3.62E-10 YDL048C STP4 hom Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress