YDR252W / BTT1

Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR252W / BTT1

Click on Significant Values for Screen Details ID:SGTC_248|Compound:streptozotocin|FD-Score:4.50|P-value:1.45E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.27|P-value:3.50E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.36|P-value:2.44E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.98|P-value:2.60E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.84|P-value:3.34E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.45|P-value:1.53E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.67|P-value:7.09E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.44|P-value:1.56E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.51|P-value:1.20E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.09|P-value:6.81E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.06|P-value:6.69E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.29|P-value:2.91E-4 ID:SGTC_1983|Compound:st071813|FD-Score:-3.21|P-value:3.86E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.06|P-value:6.78E-4 ID:SGTC_2343|Compound:7990716|FD-Score:2.99|P-value:9.84E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.15|P-value:4.88E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.01|P-value:8.10E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.70|P-value:6.25E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.12|P-value:5.50E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.30|P-value:3.99E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.39|P-value:2.18E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.69|P-value:5.65E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.28|P-value:3.37E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.14|P-value:5.03E-4 ID:SGTC_2969|Compound:9091408|FD-Score:2.99|P-value:9.76E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.14|P-value:5.15E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.11|P-value:5.65E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.91|P-value:2.12E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.50|P-value:1.45E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.27|P-value:3.50E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.36|P-value:2.44E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.98|P-value:2.60E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.84|P-value:3.34E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.45|P-value:1.53E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.67|P-value:7.09E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.44|P-value:1.56E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.51|P-value:1.20E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.09|P-value:6.81E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.06|P-value:6.69E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.29|P-value:2.91E-4 ID:SGTC_1983|Compound:st071813|FD-Score:-3.21|P-value:3.86E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.06|P-value:6.78E-4 ID:SGTC_2343|Compound:7990716|FD-Score:2.99|P-value:9.84E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.15|P-value:4.88E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.01|P-value:8.10E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.70|P-value:6.25E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.12|P-value:5.50E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.30|P-value:3.99E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.39|P-value:2.18E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.69|P-value:5.65E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.28|P-value:3.37E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.14|P-value:5.03E-4 ID:SGTC_2969|Compound:9091408|FD-Score:2.99|P-value:9.76E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.14|P-value:5.15E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.11|P-value:5.65E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.91|P-value:2.12E-5

Top fitness defect scores for YDR252W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_381 3461-2219 5.98 42.7 µM 2.60E-10 copper-dependent oxidative stress 1 1.13E-9
2 SGTC_248 streptozotocin 4.50 5.2 mM 1.45E-6 DNA damage response 17 3.33E-6
3 SGTC_2568 diosmetin 4.30 100.0 µM 3.99E-6 20 8.50E-6
4 SGTC_457 grayanotoxin iii 3.84 135.0 µM 3.34E-5 75 6.11E-5
5 SGTC_2516 gossypol 3.70 71.5 µM 6.25E-5 17 1.09E-4
6 SGTC_647 0140-0236 3.67 81.0 µM 7.09E-5 15 1.23E-4
7 SGTC_311 1315-0136 3.46 58.0 µM 1.63E-4 22 2.66E-4
8 SGTC_2675 theaflavin digallate 3.39 100.0 µM 2.18E-4 iron homeostasis 51 3.49E-4
9 SGTC_374 0880-0231 3.36 82.3 µM 2.44E-4 iron homeostasis 51 3.88E-4
10 SGTC_2930 9013230 3.28 14.9 µM 3.37E-4 heme biosynthesis & mitochondrial translocase 69 5.23E-4
11 SGTC_334 1502-1024 3.27 68.5 µM 3.50E-4 27 5.42E-4
12 SGTC_1230 0170-0365 3.09 3.8 µM 6.81E-4 endomembrane recycling 129 0.00101
13 SGTC_2969 9091408 2.99 28.7 µM 9.76E-4 80 0.00141
14 SGTC_2343 7990716 2.99 14.8 µM 9.84E-4 53 0.00142
15 SGTC_620 0109-0052 2.96 432.0 µM 0.00108 59 0.00155
16 SGTC_1229 0139-0193 2.92 12.2 µM 0.00125 RSC complex & mRNA processing 55 0.00177
17 SGTC_2956 9076196 2.87 2.5 µM 0.00148 79 0.00208
18 SGTC_2788 5282734 2.86 71.4 µM 0.00153 122 0.00214
19 SGTC_1466 k213-0079 2.82 57.5 µM 0.00175 73 0.00242
20 SGTC_521 r062-0005 2.80 13.8 µM 0.00186 70 0.00257

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 8.28E-19 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.146 1.91E-17 YBL089W AVT5 hom Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication
0.119 4.77E-12 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.118 7.86E-12 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.114 3.06E-11 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.113 5.63E-11 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.110 1.89E-10 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.107 4.69E-10 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.106 7.68E-10 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.103 1.90E-9 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.103 2.66E-9 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.102 3.43E-9 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.102 3.60E-9 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.102 3.80E-9 YBR088C POL30 het Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.101 5.38E-9 YOR203W_d YOR203W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation