YDR256C / CTA1

Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR256C / CTA1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.03|P-value:1.98E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.21|P-value:5.51E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.12|P-value:7.42E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.48|P-value:2.47E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.33|P-value:3.45E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.21|P-value:5.48E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.17|P-value:6.93E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:4.86|P-value:3.66E-7 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.34|P-value:3.49E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.11|P-value:7.99E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.10|P-value:1.45E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.17|P-value:6.36E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.14|P-value:1.19E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.33|P-value:3.63E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.96|P-value:2.86E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.14|P-value:6.85E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.84|P-value:4.59E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.24|P-value:4.84E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.78|P-value:6.18E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.51|P-value:1.83E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.03|P-value:9.91E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.33|P-value:3.67E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-4.14|P-value:1.28E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.09|P-value:8.05E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.13|P-value:6.96E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.32|P-value:3.52E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.48|P-value:2.02E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.24|P-value:4.81E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.20|P-value:9.43E-6 ID:SGTC_1920|Compound:st075728|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-4.69|P-value:9.27E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.46|P-value:2.17E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.70|P-value:8.19E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.05|P-value:9.19E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.88|P-value:3.90E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.80|P-value:5.24E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.57|P-value:1.58E-6 ID:SGTC_2344|Compound:7990960|FD-Score:-3.23|P-value:5.15E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:2.33E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.28|P-value:4.18E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.18|P-value:5.99E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.40|P-value:2.82E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:5.55|P-value:7.78E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.43|P-value:2.51E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.28|P-value:4.12E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.35|P-value:4.72E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.73|P-value:7.26E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.76|P-value:6.21E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.26|P-value:6.91E-6 ID:SGTC_2796|Compound:7949634|FD-Score:5.46|P-value:1.29E-8 ID:SGTC_2797|Compound:7859098|FD-Score:4.43|P-value:3.17E-6 ID:SGTC_3011|Compound:9081274|FD-Score:3.27|P-value:4.20E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.33|P-value:3.38E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.13|P-value:7.15E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.06|P-value:8.96E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.22|P-value:5.12E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.03|P-value:1.98E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.21|P-value:5.51E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.12|P-value:7.42E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.48|P-value:2.47E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.33|P-value:3.45E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.21|P-value:5.48E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.17|P-value:6.93E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:4.86|P-value:3.66E-7 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.34|P-value:3.49E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.11|P-value:7.99E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.10|P-value:1.45E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.17|P-value:6.36E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.14|P-value:1.19E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.33|P-value:3.63E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.96|P-value:2.86E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.14|P-value:6.85E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.84|P-value:4.59E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.24|P-value:4.84E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.78|P-value:6.18E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.51|P-value:1.83E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.03|P-value:9.91E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.33|P-value:3.67E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-4.14|P-value:1.28E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.09|P-value:8.05E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.13|P-value:6.96E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.32|P-value:3.52E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.48|P-value:2.02E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.24|P-value:4.81E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.20|P-value:9.43E-6 ID:SGTC_1920|Compound:st075728|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-4.69|P-value:9.27E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.46|P-value:2.17E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.70|P-value:8.19E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.05|P-value:9.19E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.88|P-value:3.90E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.80|P-value:5.24E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.57|P-value:1.58E-6 ID:SGTC_2344|Compound:7990960|FD-Score:-3.23|P-value:5.15E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:2.33E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.28|P-value:4.18E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.18|P-value:5.99E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.40|P-value:2.82E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:5.55|P-value:7.78E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.43|P-value:2.51E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.28|P-value:4.12E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.35|P-value:4.72E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.73|P-value:7.26E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.76|P-value:6.21E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.26|P-value:6.91E-6 ID:SGTC_2796|Compound:7949634|FD-Score:5.46|P-value:1.29E-8 ID:SGTC_2797|Compound:7859098|FD-Score:4.43|P-value:3.17E-6 ID:SGTC_3011|Compound:9081274|FD-Score:3.27|P-value:4.20E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.33|P-value:3.38E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.13|P-value:7.15E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.06|P-value:8.96E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.22|P-value:5.12E-4

Top fitness defect scores for YDR256C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2586 curcumin 5.55 80.0 µM 7.78E-9 iron homeostasis 24 1.43E-8
2 SGTC_2796 7949634 5.46 45.5 µM 1.29E-8 8 2.32E-8
3 SGTC_64 000l-0018 5.21 272.1 µM 5.51E-8 ubiquinone biosynthesis & proteasome 102 9.44E-8
4 SGTC_868 0527-0199 5.17 213.0 µM 6.93E-8 fatty acid desaturase (OLE1) 13 1.18E-7
5 SGTC_872 0588-0139 4.86 234.0 µM 3.66E-7 16 5.87E-7
6 SGTC_2291 7917025 4.57 104.3 µM 1.58E-6 iron homeostasis 34 2.40E-6
7 SGTC_431 k089-0097 4.48 107.0 µM 2.47E-6 iron homeostasis 22 3.72E-6
8 SGTC_2797 7859098 4.43 81.8 µM 3.17E-6 22 4.72E-6
9 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.35 100.0 µM 4.72E-6 26 6.94E-6
10 SGTC_2795 7780010 4.26 54.5 µM 6.91E-6 21 1.00E-5
11 SGTC_1759 st043059 4.20 70.0 µM 9.43E-6 amide catabolism 18 1.35E-5
12 SGTC_1920 st075728 4.15 45.7 µM 1.15E-5 19 1.63E-5
13 SGTC_1035 k081-0041 4.14 55.2 µM 1.19E-5 Golgi 17 1.70E-5
14 SGTC_967 1306-0166 4.10 352.0 µM 1.45E-5 29 2.05E-5
15 SGTC_8 0354-0001 4.03 70.0 µM 1.98E-5 75 2.77E-5
16 SGTC_2249 haloperidol 3.88 116.4 µM 3.90E-5 ergosterol depletion effects on membrane 120 5.32E-5
17 SGTC_1214 0358-0031 3.84 63.7 µM 4.59E-5 23 6.24E-5
18 SGTC_2275 7947463 3.80 200.0 µM 5.24E-5 iron homeostasis 39 7.09E-5
19 SGTC_2768 sulfasalazine 3.76 50.2 µM 6.21E-5 21 8.36E-5
20 SGTC_2640 pentamidine 3.73 10.4 µM 7.26E-5 mitochondrial processes 39 9.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 1.89E-36 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.170 3.04E-23 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.168 1.37E-22 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.139 5.28E-16 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 7.46E-14 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.119 3.76E-12 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.114 3.69E-11 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.112 8.87E-11 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.112 9.49E-11 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.106 6.59E-10 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.106 7.79E-10 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.105 1.05E-9 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.37E-9 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.104 1.37E-9 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.101 3.94E-9 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly