YDR259C / YAP6

Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR259C / YAP6

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:5.13|P-value:1.08E-8 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.46|P-value:9.28E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.74|P-value:2.20E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.45|P-value:7.95E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:2.93|P-value:6.83E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.13|P-value:3.14E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.87|P-value:9.87E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.83|P-value:9.87E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.44|P-value:8.49E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-2.94|P-value:7.69E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.34|P-value:1.09E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.99|P-value:5.36E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.21|P-value:2.72E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.39|P-value:1.07E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.01|P-value:7.55E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:2.98|P-value:5.60E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.52|P-value:5.97E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.84|P-value:1.39E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.08|P-value:4.45E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.05|P-value:4.21E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.86|P-value:1.50E-5 ID:SGTC_1802|Compound:st050112|FD-Score:-3.58|P-value:5.50E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.26|P-value:2.14E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.63|P-value:3.63E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.73|P-value:2.77E-5 ID:SGTC_2017|Compound:5132927|FD-Score:2.90|P-value:7.39E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.89|P-value:6.30E-8 ID:SGTC_2090|Compound:5301565|FD-Score:-3.65|P-value:4.00E-5 ID:SGTC_2476|Compound:5806916|FD-Score:2.94|P-value:6.43E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.66|P-value:3.94E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-2.87|P-value:9.83E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.88|P-value:9.67E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.76|P-value:1.03E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-2.97|P-value:6.92E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.24|P-value:2.00E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.51|P-value:6.34E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-3.14|P-value:3.52E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.94|P-value:8.55E-6 ID:SGTC_3193|Compound:9111931|FD-Score:3.66|P-value:3.15E-5 ID:SGTC_3203|Compound:9113543|FD-Score:4.75|P-value:1.09E-7 ID:SGTC_3207|Compound:9114163|FD-Score:3.99|P-value:6.65E-6 ID:SGTC_3289|Compound:9119912|FD-Score:4.01|P-value:5.84E-6 ID:SGTC_3290|Compound:9121031|FD-Score:5.75|P-value:1.83E-10 ID:SGTC_3298|Compound:9116858|FD-Score:2.88|P-value:8.21E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.21|P-value:2.28E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_3330|Compound:9141424|FD-Score:2.84|P-value:9.50E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:5.13|P-value:1.08E-8 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.46|P-value:9.28E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.74|P-value:2.20E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.45|P-value:7.95E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:2.93|P-value:6.83E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.13|P-value:3.14E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.87|P-value:9.87E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.83|P-value:9.87E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.44|P-value:8.49E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-2.94|P-value:7.69E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.34|P-value:1.09E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.99|P-value:5.36E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.21|P-value:2.72E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.39|P-value:1.07E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.01|P-value:7.55E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:2.98|P-value:5.60E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.52|P-value:5.97E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.84|P-value:1.39E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.08|P-value:4.45E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.05|P-value:4.21E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.86|P-value:1.50E-5 ID:SGTC_1802|Compound:st050112|FD-Score:-3.58|P-value:5.50E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.26|P-value:2.14E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.63|P-value:3.63E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.73|P-value:2.77E-5 ID:SGTC_2017|Compound:5132927|FD-Score:2.90|P-value:7.39E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.89|P-value:6.30E-8 ID:SGTC_2090|Compound:5301565|FD-Score:-3.65|P-value:4.00E-5 ID:SGTC_2476|Compound:5806916|FD-Score:2.94|P-value:6.43E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.66|P-value:3.94E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-2.87|P-value:9.83E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.88|P-value:9.67E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.76|P-value:1.03E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-2.97|P-value:6.92E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.24|P-value:2.00E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.51|P-value:6.34E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-3.14|P-value:3.52E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.94|P-value:8.55E-6 ID:SGTC_3193|Compound:9111931|FD-Score:3.66|P-value:3.15E-5 ID:SGTC_3203|Compound:9113543|FD-Score:4.75|P-value:1.09E-7 ID:SGTC_3207|Compound:9114163|FD-Score:3.99|P-value:6.65E-6 ID:SGTC_3289|Compound:9119912|FD-Score:4.01|P-value:5.84E-6 ID:SGTC_3290|Compound:9121031|FD-Score:5.75|P-value:1.83E-10 ID:SGTC_3298|Compound:9116858|FD-Score:2.88|P-value:8.21E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.21|P-value:2.28E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_3330|Compound:9141424|FD-Score:2.84|P-value:9.50E-4

Top fitness defect scores for YDR259C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3290 9121031 5.75 71.4 µM 1.83E-10 1 4.51E-9
2 SGTC_180 1486-1293 5.13 102.8 µM 1.08E-8 20 1.43E-7
3 SGTC_2794 7785382 4.76 27.3 µM 1.03E-7 10 9.71E-7
4 SGTC_3203 9113543 4.75 49.5 µM 1.09E-7 13 1.02E-6
5 SGTC_1170 0310-0127 4.34 64.8 µM 1.09E-6 15 7.22E-6
6 SGTC_3289 9119912 4.01 71.4 µM 5.84E-6 14 3.00E-5
7 SGTC_3207 9114163 3.99 49.5 µM 6.65E-6 30 3.35E-5
8 SGTC_3082 9117008 3.94 49.5 µM 8.55E-6 15 4.14E-5
9 SGTC_1730 st033808 3.84 45.1 µM 1.39E-5 36 6.24E-5
10 SGTC_1728 st035614 3.77 33.8 µM 1.87E-5 60 8.07E-5
11 SGTC_183 3914-0051 3.74 30.6 µM 2.20E-5 60S ribosome export 29 9.25E-5
12 SGTC_3193 9111931 3.66 49.5 µM 3.15E-5 32 1.26E-4
13 SGTC_1883 5-benzylidenerhodanine 3.63 20.0 µM 3.63E-5 TRP & mitochondrial translation 86 1.42E-4
14 SGTC_1583 clindamycin 3.52 39.6 µM 5.97E-5 mitochondrial processes 29 2.16E-4
15 SGTC_2871 9038510 3.51 13.0 µM 6.34E-5 35 2.27E-4
16 SGTC_184 1494-0393 3.45 24.7 µM 7.95E-5 85 2.76E-4
17 SGTC_1014 4130-3005 3.44 69.3 µM 8.49E-5 34 2.92E-4
18 SGTC_1446 4239-0190 3.39 62.0 µM 1.07E-4 57 3.55E-4
19 SGTC_2867 9039098 3.24 71.4 µM 2.00E-4 iron homeostasis 69 6.04E-4
20 SGTC_3305 9127027 3.21 53.8 µM 2.28E-4 45 6.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.18E-21 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.123 1.05E-12 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.121 2.15E-12 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.107 4.32E-10 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.105 9.31E-10 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.100 6.84E-9 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.100 7.96E-9 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.099 1.10E-8 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.098 1.37E-8 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.090 1.88E-7 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.088 3.86E-7 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.087 4.70E-7 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.085 8.71E-7 YGL158W RCK1 hom Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
0.085 9.58E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.084 1.31E-6 YDR113C PDS1 het Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation