YDR261C / EXG2

Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR261C / EXG2

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.32|P-value:1.90E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-2.95|P-value:7.65E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.99|P-value:9.51E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.28|P-value:2.15E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.71|P-value:3.63E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.27|P-value:2.34E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.09|P-value:4.64E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.51|P-value:8.60E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.22|P-value:2.78E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.36|P-value:1.55E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.16|P-value:3.67E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.42|P-value:1.27E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:2.95|P-value:8.08E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.67|P-value:2.80E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.53|P-value:7.46E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:3.53|P-value:7.97E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.57|P-value:4.85E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:3.36|P-value:1.59E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.54|P-value:7.27E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.49|P-value:8.79E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.68|P-value:4.10E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-2.97|P-value:7.25E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.11|P-value:4.35E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-4.36|P-value:1.47E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:-2.90|P-value:9.19E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.95|P-value:7.92E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.72|P-value:2.12E-7 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.24|P-value:2.88E-6 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.08|P-value:4.89E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.27|P-value:2.32E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.44|P-value:1.16E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.92|P-value:1.37E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.44|P-value:1.14E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.79|P-value:2.49E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.16|P-value:3.65E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.62|P-value:5.36E-5 ID:SGTC_1651|Compound:st011928|FD-Score:-4.21|P-value:3.05E-6 ID:SGTC_1656|Compound:st012921|FD-Score:3.82|P-value:2.17E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.47|P-value:1.04E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.25|P-value:2.52E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.48|P-value:9.65E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.41|P-value:1.29E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.08|P-value:6.28E-6 ID:SGTC_2239|Compound:6685329|FD-Score:7.83|P-value:2.56E-17 ID:SGTC_2296|Compound:7971656|FD-Score:6.72|P-value:3.00E-13 ID:SGTC_2303|Compound:7774051|FD-Score:5.93|P-value:1.07E-10 ID:SGTC_2310|Compound:7668677|FD-Score:3.44|P-value:1.14E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.27|P-value:2.27E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.22|P-value:2.83E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.67|P-value:4.21E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.11|P-value:4.30E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.42|P-value:1.20E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.23|P-value:2.74E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.22|P-value:2.85E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.54|P-value:5.91E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.03|P-value:5.77E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:3.36E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.40|P-value:1.31E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.26|P-value:2.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-5.05|P-value:3.06E-8 ID:SGTC_2809|Compound:7964133|FD-Score:3.31|P-value:1.97E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.31|P-value:1.96E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.01|P-value:6.07E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.93|P-value:8.17E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.23|P-value:2.69E-4 ID:SGTC_3264|Compound:9137442|FD-Score:2.97|P-value:7.51E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.24|P-value:2.47E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.32|P-value:1.93E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.29|P-value:2.18E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.32|P-value:1.90E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-2.95|P-value:7.65E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.99|P-value:9.51E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.28|P-value:2.15E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.71|P-value:3.63E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.27|P-value:2.34E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.09|P-value:4.64E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.51|P-value:8.60E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.22|P-value:2.78E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.36|P-value:1.55E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.16|P-value:3.67E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.42|P-value:1.27E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:2.95|P-value:8.08E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.67|P-value:2.80E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.53|P-value:7.46E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:3.53|P-value:7.97E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:4.57|P-value:4.85E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:3.36|P-value:1.59E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.54|P-value:7.27E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.49|P-value:8.79E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.68|P-value:4.10E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-2.97|P-value:7.25E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.11|P-value:4.35E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-4.36|P-value:1.47E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:-2.90|P-value:9.19E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.95|P-value:7.92E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.72|P-value:2.12E-7 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.24|P-value:2.88E-6 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.08|P-value:4.89E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.27|P-value:2.32E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.44|P-value:1.16E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.92|P-value:1.37E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.44|P-value:1.14E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.79|P-value:2.49E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.16|P-value:3.65E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.62|P-value:5.36E-5 ID:SGTC_1651|Compound:st011928|FD-Score:-4.21|P-value:3.05E-6 ID:SGTC_1656|Compound:st012921|FD-Score:3.82|P-value:2.17E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.47|P-value:1.04E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.25|P-value:2.52E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.48|P-value:9.65E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.41|P-value:1.29E-4 ID:SGTC_2208|Compound:7283366|FD-Score:4.08|P-value:6.28E-6 ID:SGTC_2239|Compound:6685329|FD-Score:7.83|P-value:2.56E-17 ID:SGTC_2296|Compound:7971656|FD-Score:6.72|P-value:3.00E-13 ID:SGTC_2303|Compound:7774051|FD-Score:5.93|P-value:1.07E-10 ID:SGTC_2310|Compound:7668677|FD-Score:3.44|P-value:1.14E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.27|P-value:2.27E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.22|P-value:2.83E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.67|P-value:4.21E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.11|P-value:4.30E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.42|P-value:1.20E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.23|P-value:2.74E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.22|P-value:2.85E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.54|P-value:5.91E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.03|P-value:5.77E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:3.36E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.40|P-value:1.31E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.26|P-value:2.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-5.05|P-value:3.06E-8 ID:SGTC_2809|Compound:7964133|FD-Score:3.31|P-value:1.97E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.31|P-value:1.96E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.01|P-value:6.07E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-2.93|P-value:8.17E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.23|P-value:2.69E-4 ID:SGTC_3264|Compound:9137442|FD-Score:2.97|P-value:7.51E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.24|P-value:2.47E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.32|P-value:1.93E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.29|P-value:2.18E-4

Top fitness defect scores for YDR261C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2239 6685329 7.83 187.6 µM 2.56E-17 1 2.50E-15
2 SGTC_2296 7971656 6.72 126.5 µM 3.00E-13 8 8.91E-12
3 SGTC_2303 7774051 5.93 200.0 µM 1.07E-10 5 1.51E-9
4 SGTC_1388 3346-4487 4.72 254.0 µM 2.12E-7 7 1.15E-6
5 SGTC_669 0108-0021 4.67 26.2 µM 2.80E-7 fatty acid desaturase (OLE1) 51 1.48E-6
6 SGTC_815 1582-0027 4.57 36.9 µM 4.85E-7 12 2.39E-6
7 SGTC_2442 5158906 4.54 48.5 µM 5.91E-7 12 2.84E-6
8 SGTC_1409 3909-8004 4.24 61.9 µM 2.88E-6 9 1.14E-5
9 SGTC_2208 7283366 4.08 200.0 µM 6.28E-6 8 2.25E-5
10 SGTC_40 0327-0103 3.99 19.8 µM 9.51E-6 31 3.24E-5
11 SGTC_1551 6-bromo-3'-methylflavone 3.92 63.5 µM 1.37E-5 14 4.45E-5
12 SGTC_1656 st012921 3.82 11.0 µM 2.17E-5 35 6.70E-5
13 SGTC_1620 st003704 3.79 16.5 µM 2.49E-5 20 7.54E-5
14 SGTC_176 1486-1328 3.71 72.8 µM 3.63E-5 67 1.05E-4
15 SGTC_941 3237-0776 3.68 460.0 µM 4.10E-5 25 1.17E-4
16 SGTC_2344 7990960 3.67 77.0 µM 4.21E-5 32 1.19E-4
17 SGTC_1646 st011709 3.62 75.6 µM 5.36E-5 21 1.48E-4
18 SGTC_758 0868-0029 3.53 16.0 µM 7.97E-5 11 2.09E-4
19 SGTC_284 0988-0104 3.51 32.6 µM 8.60E-5 heme requiring 18 2.24E-4
20 SGTC_1900 st060200 3.48 72.8 µM 9.65E-5 31 2.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.69E-10 YCR075C ERS1 hom Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
0.096 2.75E-8 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.090 1.79E-7 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.088 3.34E-7 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.084 1.10E-6 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.083 1.63E-6 YHR132W-A IGO2 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p
0.080 3.41E-6 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.080 3.68E-6 YOR114W_p YOR114W_p hom Putative protein of unknown function; null mutant is viable
0.078 5.89E-6 YDR493W MZM1 hom Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog
0.078 7.00E-6 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.076 1.00E-5 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.076 1.03E-5 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.075 1.33E-5 YML027W YOX1 hom Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication
0.075 1.59E-5 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.074 1.59E-5 YOR326W MYO2 het Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication