HIPHOP chemogenomics database
YDR261C / EXG2 
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YDR261C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.110 | 1.69E-10 | YCR075C | ERS1 | hom | Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains |
| 0.096 | 2.75E-8 | YPR096C | YPR096C | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments |
| 0.090 | 1.79E-7 | YGR152C | RSR1 | hom | GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases |
| 0.088 | 3.34E-7 | YBL066C | SEF1 | hom | Putative transcription factor, has homolog in Kluyveromyces lactis |
| 0.084 | 1.10E-6 | YER075C | PTP3 | hom | Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm |
| 0.083 | 1.63E-6 | YHR132W-A | IGO2 | hom | Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p |
| 0.080 | 3.41E-6 | YJR053W | BFA1 | hom | Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis |
| 0.080 | 3.68E-6 | YOR114W_p | YOR114W_p | hom | Putative protein of unknown function; null mutant is viable |
| 0.078 | 5.89E-6 | YDR493W | MZM1 | hom | Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog |
| 0.078 | 7.00E-6 | YIL154C | IMP2' | hom | Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat |
| 0.076 | 1.00E-5 | YLL011W | SOF1 | het | Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p |
| 0.076 | 1.03E-5 | YDL133C-A | RPL41B | hom | Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication |
| 0.075 | 1.33E-5 | YML027W | YOX1 | hom | Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication |
| 0.075 | 1.59E-5 | YIR013C | GAT4 | hom | Protein containing GATA family zinc finger motifs |
| 0.074 | 1.59E-5 | YOR326W | MYO2 | het | Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication |