HIPHOP chemogenomics database
YDR262W_p 
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR262W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.152 | 7.25E-19 | YKL106C-A_p | YKL106C-A_p | hom | Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi |
| 0.150 | 2.75E-18 | YBL034C | STU1 | het | Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles |
| 0.132 | 1.32E-14 | YMR308C | PSE1 | het | Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p |
| 0.128 | 8.34E-14 | YOL075C_p | YOL075C_p | hom | Putative ABC transporter |
| 0.126 | 2.87E-13 | YDR105C | TMS1 | hom | Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance |
| 0.124 | 5.94E-13 | YOR047C | STD1 | hom | Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] |
| 0.123 | 1.04E-12 | YHR063C | PAN5 | hom | 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE |
| 0.120 | 2.91E-12 | YGR067C_p | YGR067C_p | hom | Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
| 0.116 | 1.55E-11 | YML064C | TEM1 | het | GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis |
| 0.108 | 3.30E-10 | YDR277C | MTH1 | hom | Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
| 0.103 | 2.15E-9 | YJL135W_d | YJL135W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 |
| 0.102 | 3.01E-9 | YKR032W_d | YKR032W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.102 | 3.77E-9 | YGR295C | COS6 | hom | Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
| 0.100 | 6.48E-9 | YGR161C_p | RTS3_p | hom | Putative component of the protein phosphatase type 2A complex |
| 0.098 | 1.30E-8 | YDR252W | BTT1 | hom | Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 |