YDR262W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR262W / YDR262W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-2.92|P-value:4.41E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.22|P-value:1.20E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.91|P-value:4.53E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.33|P-value:4.10E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:2.74|P-value:8.89E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.01|P-value:2.98E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.11|P-value:1.44E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:2.97|P-value:3.63E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.12|P-value:1.86E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.49|P-value:1.58E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:3.58|P-value:2.23E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.58|P-value:2.25E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:-2.85|P-value:5.92E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:2.77|P-value:8.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.68|P-value:1.38E-5 ID:SGTC_1634|Compound:st006576|FD-Score:2.87|P-value:5.35E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.11|P-value:1.99E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.50|P-value:1.52E-7 ID:SGTC_1731|Compound:st035964|FD-Score:3.46|P-value:4.06E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.87|P-value:5.22E-6 ID:SGTC_1891|Compound:st059073|FD-Score:2.99|P-value:3.30E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.00|P-value:3.17E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.17|P-value:1.50E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.13|P-value:1.78E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-3.99|P-value:2.75E-6 ID:SGTC_2378|Compound:9074213|FD-Score:-2.90|P-value:4.87E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.80|P-value:7.04E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.96|P-value:3.28E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.04|P-value:2.69E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.92|P-value:4.39E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.27|P-value:5.80E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:2.85|P-value:5.82E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.01|P-value:5.59E-9 ID:SGTC_2798|Compound:7813637|FD-Score:2.88|P-value:5.08E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.28|P-value:5.57E-7 ID:SGTC_2848|Compound:9016370|FD-Score:2.75|P-value:8.70E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-2.87|P-value:5.46E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.75|P-value:8.53E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.92|P-value:4.41E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.22|P-value:1.20E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:2.91|P-value:4.53E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:4.33|P-value:4.10E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:2.74|P-value:8.89E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.01|P-value:2.98E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.11|P-value:1.44E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:2.97|P-value:3.63E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.12|P-value:1.86E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.49|P-value:1.58E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:3.58|P-value:2.23E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.58|P-value:2.25E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:-2.85|P-value:5.92E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:2.77|P-value:8.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.68|P-value:1.38E-5 ID:SGTC_1634|Compound:st006576|FD-Score:2.87|P-value:5.35E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.11|P-value:1.99E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.50|P-value:1.52E-7 ID:SGTC_1731|Compound:st035964|FD-Score:3.46|P-value:4.06E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.87|P-value:5.22E-6 ID:SGTC_1891|Compound:st059073|FD-Score:2.99|P-value:3.30E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.00|P-value:3.17E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.17|P-value:1.50E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.13|P-value:1.78E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-3.99|P-value:2.75E-6 ID:SGTC_2378|Compound:9074213|FD-Score:-2.90|P-value:4.87E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.80|P-value:7.04E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.96|P-value:3.28E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.04|P-value:2.69E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.92|P-value:4.39E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.27|P-value:5.80E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:2.85|P-value:5.82E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.01|P-value:5.59E-9 ID:SGTC_2798|Compound:7813637|FD-Score:2.88|P-value:5.08E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.28|P-value:5.57E-7 ID:SGTC_2848|Compound:9016370|FD-Score:2.75|P-value:8.70E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-2.87|P-value:5.46E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.75|P-value:8.53E-4

Top fitness defect scores for YDR262W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2760 etidronate 5.01 98.0 µM 5.59E-9 11 2.67E-7
2 SGTC_602 3130-1533 4.49 38.1 µM 1.58E-7 9 3.58E-6
3 SGTC_51 1013-0126 4.33 23.4 µM 4.10E-7 25 7.53E-6
4 SGTC_212 3807-4682 4.11 38.8 µM 1.44E-6 tubulin folding & SWR complex 63 2.00E-5
5 SGTC_2568 diosmetin 3.96 100.0 µM 3.28E-6 25 3.80E-5
6 SGTC_1451 4152-0210 3.68 104.0 µM 1.38E-5 35 1.16E-4
7 SGTC_933 2914-0560 3.58 114.0 µM 2.23E-5 34 1.70E-4
8 SGTC_1170 0310-0127 3.58 64.8 µM 2.25E-5 40 1.70E-4
9 SGTC_1731 st035964 3.46 63.0 µM 4.06E-5 49 2.71E-4
10 SGTC_43 0570-0105 3.22 72.5 µM 1.20E-4 ERG2 159 6.33E-4
11 SGTC_2067 5224629 3.17 34.1 µM 1.50E-4 53 7.55E-4
12 SGTC_2333 9017922 3.13 200.0 µM 1.78E-4 59 8.60E-4
13 SGTC_457 grayanotoxin iii 3.12 135.0 µM 1.86E-4 134 8.90E-4
14 SGTC_186 3455-3465 3.01 67.3 µM 2.98E-4 11 0.00129
15 SGTC_1891 st059073 2.99 26.2 µM 3.30E-4 TSC3-RPN4 69 0.00140
16 SGTC_214 4373-3496 2.97 70.0 µM 3.63E-4 135 0.00150
17 SGTC_46 0329-0187a 2.91 2.2 µM 4.53E-4 144 0.00179
18 SGTC_2798 7813637 2.88 45.5 µM 5.08E-4 91 0.00196
19 SGTC_1634 st006576 2.87 41.0 µM 5.35E-4 TSC3-RPN4 71 0.00204
20 SGTC_2639 lactacystin 2.85 53.0 µM 5.82E-4 81 0.00218

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 7.25E-19 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.150 2.75E-18 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.132 1.32E-14 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.128 8.34E-14 YOL075C_p YOL075C_p hom Putative ABC transporter
0.126 2.87E-13 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.124 5.94E-13 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.123 1.04E-12 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
0.120 2.91E-12 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.116 1.55E-11 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.108 3.30E-10 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.103 2.15E-9 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.102 3.01E-9 YKR032W_d YKR032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.77E-9 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.100 6.48E-9 YGR161C_p RTS3_p hom Putative component of the protein phosphatase type 2A complex
0.098 1.30E-8 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3