YDR272W / GLO2

Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR272W / GLO2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.02|P-value:8.99E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:11.60|P-value:2.40E-34 ID:SGTC_331|Compound:k048-0133|FD-Score:3.10|P-value:6.69E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.65|P-value:4.90E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:6.19|P-value:5.39E-11 ID:SGTC_412|Compound:gemfibrozil|FD-Score:5.19|P-value:3.33E-8 ID:SGTC_413|Compound:propylparaben|FD-Score:3.83|P-value:3.53E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:-2.92|P-value:9.03E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.37|P-value:2.37E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.08|P-value:7.33E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.42|P-value:2.01E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.69|P-value:4.19E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.30|P-value:3.91E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.55|P-value:1.14E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.45|P-value:1.77E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.02|P-value:6.26E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.14|P-value:5.89E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.46|P-value:1.65E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.17|P-value:7.41E-6 ID:SGTC_1856|Compound:st057054|FD-Score:-3.94|P-value:1.38E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.36|P-value:1.65E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.57|P-value:7.10E-5 ID:SGTC_2083|Compound:5306046|FD-Score:-3.11|P-value:4.35E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.02|P-value:1.49E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.70|P-value:6.23E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.13|P-value:6.03E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.29|P-value:2.21E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.26|P-value:4.87E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.79|P-value:2.70E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.90|P-value:2.59E-5 ID:SGTC_2701|Compound:st077767|FD-Score:3.75|P-value:5.00E-5 ID:SGTC_2710|Compound:st078562|FD-Score:3.64|P-value:8.13E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-3.41|P-value:1.39E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.94|P-value:2.19E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.65|P-value:7.63E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-2.95|P-value:7.95E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.55|P-value:7.69E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.48|P-value:1.63E-6 ID:SGTC_2980|Compound:9014342|FD-Score:3.59|P-value:9.78E-5 ID:SGTC_3009|Compound:9080819|FD-Score:-3.10|P-value:4.68E-4 ID:SGTC_3081|Compound:9117243|FD-Score:5.29|P-value:1.83E-8 ID:SGTC_3140|Compound:9094243|FD-Score:-2.96|P-value:7.77E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.47|P-value:1.62E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.81|P-value:2.47E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.02|P-value:8.99E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:11.60|P-value:2.40E-34 ID:SGTC_331|Compound:k048-0133|FD-Score:3.10|P-value:6.69E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.65|P-value:4.90E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:6.19|P-value:5.39E-11 ID:SGTC_412|Compound:gemfibrozil|FD-Score:5.19|P-value:3.33E-8 ID:SGTC_413|Compound:propylparaben|FD-Score:3.83|P-value:3.53E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:-2.92|P-value:9.03E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.37|P-value:2.37E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.08|P-value:7.33E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.42|P-value:2.01E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.69|P-value:4.19E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.30|P-value:3.91E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.55|P-value:1.14E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.45|P-value:1.77E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.02|P-value:6.26E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.14|P-value:5.89E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.46|P-value:1.65E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.17|P-value:7.41E-6 ID:SGTC_1856|Compound:st057054|FD-Score:-3.94|P-value:1.38E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.36|P-value:1.65E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.57|P-value:7.10E-5 ID:SGTC_2083|Compound:5306046|FD-Score:-3.11|P-value:4.35E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.02|P-value:1.49E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.70|P-value:6.23E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.13|P-value:6.03E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.29|P-value:2.21E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.26|P-value:4.87E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.79|P-value:2.70E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.90|P-value:2.59E-5 ID:SGTC_2701|Compound:st077767|FD-Score:3.75|P-value:5.00E-5 ID:SGTC_2710|Compound:st078562|FD-Score:3.64|P-value:8.13E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-3.41|P-value:1.39E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.94|P-value:2.19E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.65|P-value:7.63E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-2.95|P-value:7.95E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.55|P-value:7.69E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.48|P-value:1.63E-6 ID:SGTC_2980|Compound:9014342|FD-Score:3.59|P-value:9.78E-5 ID:SGTC_3009|Compound:9080819|FD-Score:-3.10|P-value:4.68E-4 ID:SGTC_3081|Compound:9117243|FD-Score:5.29|P-value:1.83E-8 ID:SGTC_3140|Compound:9094243|FD-Score:-2.96|P-value:7.77E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.47|P-value:1.62E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.81|P-value:2.47E-5

Top fitness defect scores for YDR272W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_81 0411-0046 11.60 10.0 µM 2.40E-34 1 1.65E-31
2 SGTC_407 eburnamonine 6.19 100.0 µM 5.39E-11 3 3.00E-10
3 SGTC_3081 9117243 5.29 49.5 µM 1.83E-8 fatty acid desaturase (OLE1) 8 6.19E-8
4 SGTC_412 gemfibrozil 5.19 100.0 µM 3.33E-8 DNA intercalators 2 1.07E-7
5 SGTC_1230 0170-0365 4.55 3.8 µM 1.14E-6 endomembrane recycling 42 2.74E-6
6 SGTC_2957 9076800 4.48 11.5 µM 1.63E-6 17 3.79E-6
7 SGTC_1044 1222-0021 4.30 1.8 µM 3.91E-6 heme biosynthesis & mitochondrial translocase 29 8.47E-6
8 SGTC_2537 larixol 4.26 68.9 µM 4.87E-6 17 1.04E-5
9 SGTC_1782 st039423 4.17 80.6 µM 7.41E-6 16 1.52E-5
10 SGTC_2712 st079126 4.10 47.7 µM 1.05E-5 12 2.10E-5
11 SGTC_2102 5377816 4.02 72.8 µM 1.49E-5 27 2.90E-5
12 SGTC_2853 9015042 3.94 58.4 µM 2.19E-5 24 4.12E-5
13 SGTC_2654 protoveratrine a 3.90 100.0 µM 2.59E-5 7 4.81E-5
14 SGTC_413 propylparaben 3.83 100.0 µM 3.53E-5 amide catabolism 25 6.39E-5
15 SGTC_2701 st077767 3.75 14.7 µM 5.00E-5 47 8.80E-5
16 SGTC_2126 5251174 3.70 33.9 µM 6.23E-5 49 1.08E-4
17 SGTC_2930 9013230 3.65 14.9 µM 7.63E-5 heme biosynthesis & mitochondrial translocase 51 1.30E-4
18 SGTC_2710 st078562 3.64 53.7 µM 8.13E-5 28 1.38E-4
19 SGTC_2980 9014342 3.59 25.3 µM 9.78E-5 47 1.63E-4
20 SGTC_3217 9129673 3.56 49.5 µM 1.12E-4 56 1.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 8.84E-27 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.182 2.03E-26 YPR094W RDS3 het Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
0.155 1.80E-19 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.135 4.65E-15 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.127 1.66E-13 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.125 3.40E-13 YML004C GLO1 hom Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
0.118 7.63E-12 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.102 2.93E-9 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.102 3.13E-9 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.098 1.36E-8 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.095 3.26E-8 YPL128C TBF1 het Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation
0.093 6.37E-8 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.090 1.53E-7 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.088 2.85E-7 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.084 1.03E-6 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole