YDR278C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR278C / YDR278C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.51|P-value:8.48E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.89|P-value:7.68E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.08|P-value:4.63E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.43|P-value:1.10E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.68|P-value:2.59E-7 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.74|P-value:2.97E-5 ID:SGTC_476|Compound:mead acid|FD-Score:3.43|P-value:1.18E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.53|P-value:7.28E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.91|P-value:8.56E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-2.90|P-value:8.95E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.89|P-value:7.88E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:4.80|P-value:1.29E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:3.04|P-value:5.55E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.11|P-value:4.28E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.38|P-value:1.36E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.01|P-value:6.28E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.02|P-value:6.00E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.09|P-value:4.41E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.56|P-value:6.22E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.69|P-value:3.82E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.98|P-value:9.74E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.11|P-value:4.23E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-2.93|P-value:8.08E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.00|P-value:8.76E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-3.18|P-value:3.07E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.42|P-value:1.22E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.03|P-value:5.79E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.89|P-value:9.85E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.46|P-value:9.85E-5 ID:SGTC_2691|Compound:st077356|FD-Score:-2.87|P-value:9.85E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.95|P-value:1.16E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.78|P-value:2.34E-5 ID:SGTC_2926|Compound:9010726|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.92|P-value:1.31E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.53|P-value:7.84E-5 ID:SGTC_3249|Compound:9135183|FD-Score:2.89|P-value:9.65E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.26|P-value:2.36E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.51|P-value:8.48E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.89|P-value:7.68E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.08|P-value:4.63E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.43|P-value:1.10E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.68|P-value:2.59E-7 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.74|P-value:2.97E-5 ID:SGTC_476|Compound:mead acid|FD-Score:3.43|P-value:1.18E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.53|P-value:7.28E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-2.91|P-value:8.56E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-2.90|P-value:8.95E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.89|P-value:7.88E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:4.80|P-value:1.29E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:3.04|P-value:5.55E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.11|P-value:4.28E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.38|P-value:1.36E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.01|P-value:6.28E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.02|P-value:6.00E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.09|P-value:4.41E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.56|P-value:6.22E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.69|P-value:3.82E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.98|P-value:9.74E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.11|P-value:4.23E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-2.93|P-value:8.08E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.00|P-value:8.76E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-3.18|P-value:3.07E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.42|P-value:1.22E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.03|P-value:5.79E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.89|P-value:9.85E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.46|P-value:9.85E-5 ID:SGTC_2691|Compound:st077356|FD-Score:-2.87|P-value:9.85E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.95|P-value:1.16E-5 ID:SGTC_2862|Compound:9027634|FD-Score:-3.78|P-value:2.34E-5 ID:SGTC_2926|Compound:9010726|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.92|P-value:1.31E-5 ID:SGTC_3100|Compound:9120536|FD-Score:3.53|P-value:7.84E-5 ID:SGTC_3249|Compound:9135183|FD-Score:2.89|P-value:9.65E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.26|P-value:2.36E-4

Top fitness defect scores for YDR278C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_46 0329-0187a 4.89 2.2 µM 7.68E-8 39 4.99E-7
2 SGTC_676 falcarinol 4.89 140.0 µM 7.88E-8 35 5.11E-7
3 SGTC_818 4072-2707 4.80 53.5 µM 1.29E-7 3 7.86E-7
4 SGTC_457 grayanotoxin iii 4.68 135.0 µM 2.59E-7 34 1.44E-6
5 SGTC_1979 st071809 4.00 45.3 µM 8.76E-6 RPP1 & pyrimidine depletion 12 3.11E-5
6 SGTC_1310 1188-0297 3.98 994.0 nM 9.74E-6 azole & statin 32 3.42E-5
7 SGTC_2823 7987624 3.95 58.4 µM 1.16E-5 31 3.97E-5
8 SGTC_2991 9074669 3.92 71.4 µM 1.31E-5 azole & statin 66 4.43E-5
9 SGTC_461 N-acetylfarnesylcysteine 3.74 136.0 µM 2.97E-5 5 9.06E-5
10 SGTC_1300 1094-0077 3.69 113.0 µM 3.82E-5 16 1.13E-4
11 SGTC_3100 9120536 3.53 49.5 µM 7.84E-5 22 2.11E-4
12 SGTC_8 0354-0001 3.51 70.0 µM 8.48E-5 100 2.27E-4
13 SGTC_476 mead acid 3.43 10.0 µM 1.18E-4 9 3.01E-4
14 SGTC_43 0570-0105 3.43 72.5 µM 1.19E-4 ERG2 140 3.05E-4
15 SGTC_2481 5478948 3.42 45.2 µM 1.22E-4 PDR1 58 3.12E-4
16 SGTC_2393 9031399 3.28 185.9 µM 2.22E-4 RNA processing & uracil transport 57 5.26E-4
17 SGTC_3341 9147222 3.26 25.9 µM 2.36E-4 RNA processing & uracil transport 35 5.54E-4
18 SGTC_1560 lithocholic acid 3.11 53.1 µM 4.23E-4 14 9.24E-4
19 SGTC_833 3852-0053 3.11 558.0 µM 4.28E-4 48 9.34E-4
20 SGTC_821 1114-0266 3.04 29.2 µM 5.55E-4 61 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.96E-15 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.133 1.10E-14 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.129 7.64E-14 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.123 8.80E-13 YDR321W ASP1 hom Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively
0.117 1.09E-11 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.114 4.29E-11 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.110 2.02E-10 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.106 8.02E-10 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.102 3.38E-9 YGR111W_p YGR111W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.101 4.69E-9 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.099 9.24E-9 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.097 1.71E-8 YDR265W PEX10 hom Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
0.094 4.31E-8 YHR083W SAM35 het Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
0.091 1.19E-7 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
0.090 1.61E-7 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT