HIPHOP chemogenomics database

YDR281C / PHM6

Protein of unknown function, expression is regulated by phosphate levels

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR281C / PHM6

Click on Significant Values for Screen Details

Top fitness defect scores for YDR281C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2810	7959871	9.27	45.5 µM	1.35E-17	copper-dependent oxidative stress	4	9.71E-21
2	SGTC_625	k213-0058	9.19	121.0 µM	2.41E-17	translation	6	1.95E-20
3	SGTC_1650	st011916	6.11	45.8 µM	1.20E-8		1	4.89E-10
4	SGTC_3296	9122258	5.45	64.0 µM	3.26E-7	redox potentiating	10	2.52E-8
5	SGTC_1353	1498-1206	5.12	8.1 µM	1.50E-6	mitochondrial response to ROS	28	1.56E-7
6	SGTC_1635	st007035	4.65	42.4 µM	1.09E-5		179	1.65E-6
7	SGTC_800	3448-7362	4.42	155.0 µM	2.77E-5	translation	125	5.02E-6
8	SGTC_1448	4255-0083	4.38	152.0 µM	3.18E-5	ERG2	11	5.91E-6
9	SGTC_2037	5169046	4.36	200.0 µM	3.43E-5	60S ribosome export	8	6.47E-6
10	SGTC_2559	tetrahydrosappanone a trimethyl ether	4.33	100.0 µM	3.92E-5		7	7.59E-6
11	SGTC_1198	1612-1005	4.31	86.7 µM	4.23E-5		5	8.29E-6
12	SGTC_1889	st059080	4.02	5.2 µM	1.22E-4		13	2.94E-5
13	SGTC_2925	9010536	3.97	32.5 µM	1.46E-4	azole & statin	50	3.62E-5
14	SGTC_2567	aureobasidin a	3.97	60.0 nM	1.47E-4		97	3.65E-5
15	SGTC_1622	st003707	3.95	19.4 µM	1.53E-4	calcium & mitochondrial duress	39	3.83E-5
16	SGTC_762	1165-0429	3.88	115.0 µM	1.97E-4	TSC3-RPN4	20	5.15E-5
17	SGTC_2134	5324836	3.83	1.5 µM	2.34E-4		17	6.35E-5
18	SGTC_1225	1216-0074	3.83	20.6 µM	2.36E-4		27	6.41E-5
19	SGTC_266	formosanin C	3.77	406.0 nM	2.89E-4	sphingolipid biosynthesis & PDR1	73	8.14E-5
20	SGTC_2106	5357045	3.74	167.3 µM	3.20E-4		24	9.21E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.190	1.79E-28	YDR516C	EMI2	hom	Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.163	2.15E-21	YER016W	BIM1	hom	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.152	9.09E-19	YOR305W	RRG7	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.138	1.14E-15	YIR021W-A_p	YIR021W-A_p	hom	Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.135	3.49E-15	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.135	4.05E-15	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.134	5.64E-15	YDR414C	ERD1	hom	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.133	1.26E-14	YIL039W	TED1	hom	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.132	1.62E-14	YGL251C	HFM1	hom	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.132	1.96E-14	YMR138W	CIN4	hom	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.131	2.69E-14	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.130	4.26E-14	YOR085W	OST3	hom	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.129	5.28E-14	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.129	8.28E-14	YBR162C	TOS1	hom	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.128	1.08E-13	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit