YDR286C_p

Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR286C / YDR286C

Click on Significant Values for Screen Details ID:SGTC_458|Compound:nppb|FD-Score:3.58|P-value:3.09E-5 ID:SGTC_490|Compound:phenamil|FD-Score:2.79|P-value:9.23E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.87|P-value:7.58E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.47|P-value:5.25E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.16|P-value:2.08E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:2.89|P-value:6.30E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.06|P-value:3.11E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.89|P-value:6.98E-6 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.91|P-value:5.76E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-4.30|P-value:7.70E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-3.51|P-value:4.42E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.88|P-value:6.44E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.57|P-value:3.33E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.39|P-value:7.58E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.51|P-value:3.67E-10 ID:SGTC_2809|Compound:7964133|FD-Score:-2.77|P-value:9.68E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.46|P-value:3.03E-7 ID:SGTC_2931|Compound:9014674|FD-Score:3.68|P-value:1.91E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.38|P-value:8.01E-5 ID:SGTC_3199|Compound:9111318|FD-Score:2.90|P-value:5.98E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.53|P-value:3.97E-5 ID:SGTC_3308|Compound:9128332|FD-Score:2.91|P-value:5.65E-4 ID:SGTC_3320|Compound:9137005|FD-Score:2.83|P-value:7.70E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.58|P-value:3.09E-5 ID:SGTC_490|Compound:phenamil|FD-Score:2.79|P-value:9.23E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.87|P-value:7.58E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.47|P-value:5.25E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.16|P-value:2.08E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:2.89|P-value:6.30E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.06|P-value:3.11E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.89|P-value:6.98E-6 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.91|P-value:5.76E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-4.30|P-value:7.70E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-3.51|P-value:4.42E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.88|P-value:6.44E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.57|P-value:3.33E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.39|P-value:7.58E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.51|P-value:3.67E-10 ID:SGTC_2809|Compound:7964133|FD-Score:-2.77|P-value:9.68E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.46|P-value:3.03E-7 ID:SGTC_2931|Compound:9014674|FD-Score:3.68|P-value:1.91E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.38|P-value:8.01E-5 ID:SGTC_3199|Compound:9111318|FD-Score:2.90|P-value:5.98E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.53|P-value:3.97E-5 ID:SGTC_3308|Compound:9128332|FD-Score:2.91|P-value:5.65E-4 ID:SGTC_3320|Compound:9137005|FD-Score:2.83|P-value:7.70E-4

Top fitness defect scores for YDR286C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2586 curcumin 5.51 80.0 µM 3.67E-10 iron homeostasis 25 1.80E-8
2 SGTC_2930 9013230 4.46 14.9 µM 3.03E-7 heme biosynthesis & mitochondrial translocase 21 4.03E-6
3 SGTC_1216 1165-0504 3.89 9.7 µM 6.98E-6 14 5.07E-5
4 SGTC_548 1436-0017 3.87 110.0 µM 7.58E-6 TSC3-RPN4 38 5.43E-5
5 SGTC_2931 9014674 3.68 55.7 µM 1.91E-5 29 1.14E-4
6 SGTC_458 nppb 3.58 133.0 µM 3.09E-5 21 1.69E-4
7 SGTC_2447 5741742 3.39 33.8 µM 7.58E-5 45 3.50E-4
8 SGTC_2935 9038016 3.38 30.0 µM 8.01E-5 35 3.66E-4
9 SGTC_3308 9128332 2.91 17.6 µM 5.65E-4 plasma membrane duress 149 0.00179
10 SGTC_1579 chlormadinone acetate 2.91 49.4 µM 5.76E-4 51 0.00182
11 SGTC_3199 9111318 2.90 49.5 µM 5.98E-4 62 0.00187
12 SGTC_943 3253-1379 2.89 105.0 µM 6.30E-4 76 0.00195
13 SGTC_2354 9060492 2.88 162.0 µM 6.44E-4 73 0.00199
14 SGTC_3320 9137005 2.83 35.1 µM 7.70E-4 endomembrane recycling 58 0.00230
15 SGTC_490 phenamil 2.79 164.0 µM 9.23E-4 heme requiring 41 0.00267
16 SGTC_407 eburnamonine 2.76 100.0 µM 0.00102 67 0.00289
17 SGTC_2255 7941087 2.75 197.4 µM 0.00104 100 0.00294
18 SGTC_1227 3909-8010 2.56 46.6 µM 0.00212 109 0.00525
19 SGTC_1330 1469-0054 2.54 61.8 µM 0.00230 iron homeostasis 100 0.00562
20 SGTC_2816 7982706 2.53 58.4 µM 0.00234 azole & statin 147 0.00570

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.09E-24 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.172 1.11E-23 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.125 4.42E-13 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.121 1.99E-12 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.112 6.47E-11 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
0.112 7.93E-11 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.11E-10 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.111 1.21E-10 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.105 9.78E-10 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.104 1.67E-9 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.103 1.90E-9 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.102 3.40E-9 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.101 4.69E-9 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.100 5.68E-9 YBR137W YBR137W hom Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene
0.098 1.16E-8 YDR256C CTA1 hom Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation