YDR289C / RTT103

Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR289C / RTT103

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.44|P-value:8.03E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.15|P-value:1.16E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:-5.14|P-value:1.17E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.91|P-value:1.61E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.46|P-value:2.11E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:4.20|P-value:5.74E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:5.53|P-value:1.96E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.38|P-value:9.70E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.61|P-value:1.33E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.62|P-value:4.57E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.91|P-value:1.12E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.46|P-value:7.45E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.53|P-value:6.12E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.01|P-value:2.11E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:5.69|P-value:8.79E-8 ID:SGTC_559|Compound:1550-0661|FD-Score:3.51|P-value:6.51E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.68|P-value:9.37E-8 ID:SGTC_603|Compound:3794-0023|FD-Score:3.49|P-value:6.77E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.54|P-value:5.85E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.03|P-value:1.08E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.54|P-value:5.80E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.40|P-value:2.14E-9 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.60|P-value:1.42E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.46|P-value:7.54E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.35|P-value:3.29E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.73|P-value:7.27E-8 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.98|P-value:2.43E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.42|P-value:2.50E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.77|P-value:2.70E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.45|P-value:7.89E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.68|P-value:8.93E-6 ID:SGTC_1163|Compound:k060-0048|FD-Score:-4.00|P-value:1.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.70|P-value:3.42E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.77|P-value:5.96E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-5.03|P-value:1.91E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.40|P-value:2.72E-5 ID:SGTC_1604|Compound:st002052|FD-Score:4.22|P-value:5.44E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-4.34|P-value:3.36E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.74|P-value:2.96E-4 ID:SGTC_1614|Compound:st002383|FD-Score:4.34|P-value:3.45E-5 ID:SGTC_1621|Compound:st003705|FD-Score:6.93|P-value:1.04E-10 ID:SGTC_1623|Compound:st003709|FD-Score:4.18|P-value:6.28E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.66|P-value:3.94E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.55|P-value:5.63E-4 ID:SGTC_1745|Compound:st081495|FD-Score:11.50|P-value:2.90E-26 ID:SGTC_1786|Compound:berberine|FD-Score:-4.35|P-value:3.25E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.52|P-value:6.10E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.83|P-value:2.19E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.09|P-value:1.50E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-4.33|P-value:3.42E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.18|P-value:6.33E-5 ID:SGTC_2192|Compound:5915882|FD-Score:9.98|P-value:2.61E-20 ID:SGTC_2220|Compound:6782180|FD-Score:4.04|P-value:1.04E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:12.00|P-value:2.61E-28 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.79|P-value:1.32E-19 ID:SGTC_2342|Compound:7990637|FD-Score:4.36|P-value:3.15E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-4.40|P-value:2.62E-5 ID:SGTC_2377|Compound:9073351|FD-Score:-3.89|P-value:1.76E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.85|P-value:2.06E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.49|P-value:6.88E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.51|P-value:6.35E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.48|P-value:7.07E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.11|P-value:8.17E-5 ID:SGTC_2896|Compound:9052656|FD-Score:9.59|P-value:6.55E-19 ID:SGTC_2954|Compound:9074818|FD-Score:3.79|P-value:2.55E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.50|P-value:6.61E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.60|P-value:4.86E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.07|P-value:1.62E-6 ID:SGTC_3149|Compound:9097855|FD-Score:4.76|P-value:6.36E-6 ID:SGTC_3155|Compound:9099265|FD-Score:4.61|P-value:1.17E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.96|P-value:1.43E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.44|P-value:8.03E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.15|P-value:1.16E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:-5.14|P-value:1.17E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.91|P-value:1.61E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.46|P-value:2.11E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:4.20|P-value:5.74E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:5.53|P-value:1.96E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:3.38|P-value:9.70E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.61|P-value:1.33E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:3.62|P-value:4.57E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.91|P-value:1.12E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.46|P-value:7.45E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.53|P-value:6.12E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.01|P-value:2.11E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:5.69|P-value:8.79E-8 ID:SGTC_559|Compound:1550-0661|FD-Score:3.51|P-value:6.51E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.68|P-value:9.37E-8 ID:SGTC_603|Compound:3794-0023|FD-Score:3.49|P-value:6.77E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.54|P-value:5.85E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.03|P-value:1.08E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.54|P-value:5.80E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.40|P-value:2.14E-9 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.60|P-value:1.42E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.46|P-value:7.54E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.35|P-value:3.29E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.73|P-value:7.27E-8 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.98|P-value:2.43E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.42|P-value:2.50E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.77|P-value:2.70E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.45|P-value:7.89E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.68|P-value:8.93E-6 ID:SGTC_1163|Compound:k060-0048|FD-Score:-4.00|P-value:1.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.70|P-value:3.42E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.77|P-value:5.96E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-5.03|P-value:1.91E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.40|P-value:2.72E-5 ID:SGTC_1604|Compound:st002052|FD-Score:4.22|P-value:5.44E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-4.34|P-value:3.36E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.74|P-value:2.96E-4 ID:SGTC_1614|Compound:st002383|FD-Score:4.34|P-value:3.45E-5 ID:SGTC_1621|Compound:st003705|FD-Score:6.93|P-value:1.04E-10 ID:SGTC_1623|Compound:st003709|FD-Score:4.18|P-value:6.28E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.66|P-value:3.94E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.55|P-value:5.63E-4 ID:SGTC_1745|Compound:st081495|FD-Score:11.50|P-value:2.90E-26 ID:SGTC_1786|Compound:berberine|FD-Score:-4.35|P-value:3.25E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.52|P-value:6.10E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.83|P-value:2.19E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.09|P-value:1.50E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-4.33|P-value:3.42E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.18|P-value:6.33E-5 ID:SGTC_2192|Compound:5915882|FD-Score:9.98|P-value:2.61E-20 ID:SGTC_2220|Compound:6782180|FD-Score:4.04|P-value:1.04E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:12.00|P-value:2.61E-28 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.79|P-value:1.32E-19 ID:SGTC_2342|Compound:7990637|FD-Score:4.36|P-value:3.15E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-4.40|P-value:2.62E-5 ID:SGTC_2377|Compound:9073351|FD-Score:-3.89|P-value:1.76E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.85|P-value:2.06E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.49|P-value:6.88E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.51|P-value:6.35E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.48|P-value:7.07E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.11|P-value:8.17E-5 ID:SGTC_2896|Compound:9052656|FD-Score:9.59|P-value:6.55E-19 ID:SGTC_2954|Compound:9074818|FD-Score:3.79|P-value:2.55E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.50|P-value:6.61E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.60|P-value:4.86E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.07|P-value:1.62E-6 ID:SGTC_3149|Compound:9097855|FD-Score:4.76|P-value:6.36E-6 ID:SGTC_3155|Compound:9099265|FD-Score:4.61|P-value:1.17E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.96|P-value:1.43E-4

Top fitness defect scores for YDR289C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2249 haloperidol 12.00 116.4 µM 2.61E-28 ergosterol depletion effects on membrane 7 3.07E-33
2 SGTC_1745 st081495 11.50 74.0 µM 2.90E-26 RNA processing & uracil transport 5 8.14E-31
3 SGTC_2192 5915882 9.98 198.5 µM 2.61E-20 RNA processing & uracil transport 2 9.29E-24
4 SGTC_2250 alverine citrate 9.79 130.0 µM 1.32E-19 10 6.34E-23
5 SGTC_2896 9052656 9.59 71.4 µM 6.55E-19 endomembrane recycling 10 4.23E-22
6 SGTC_1621 st003705 6.93 32.4 µM 1.04E-10 calcium & mitochondrial duress 5 2.17E-12
7 SGTC_312 4092-0653 6.91 6.8 µM 1.12E-10 ergosterol depletion effects on membrane 24 2.35E-12
8 SGTC_1019 4262-0212 6.40 3.4 µM 2.14E-9 ergosterol depletion effects on membrane 21 7.75E-11
9 SGTC_1058 3448-5425 5.73 97.3 µM 7.27E-8 17 5.00E-9
10 SGTC_539 4859-0462 5.69 2.5 µM 8.79E-8 RNA pol III & RNase P/MRP 4 6.25E-9
11 SGTC_568 1193-0097 5.68 7.5 µM 9.37E-8 ERAD & cell cycle 66 6.74E-9
12 SGTC_218 alverine citrate 5.61 93.8 µM 1.33E-7 fatty acid desaturase (OLE1) 15 1.02E-8
13 SGTC_1026 k007-1105 5.60 30.6 µM 1.42E-7 ERAD & cell cycle 49 1.10E-8
14 SGTC_201 4262-0159 5.53 12.8 µM 1.96E-7 ergosterol depletion effects on membrane 20 1.61E-8
15 SGTC_87 0100-0052 5.15 35.5 µM 1.16E-6 48 1.31E-7
16 SGTC_1894 3',6'-dihydroxyflavone 5.09 78.7 µM 1.50E-6 5 1.79E-7
17 SGTC_2997 9067075 5.07 71.4 µM 1.62E-6 unfolded protein response 28 1.96E-7
18 SGTC_398 bronopol 5.01 33.3 µM 2.11E-6 RNA processing & uracil transport 15 2.66E-7
19 SGTC_1072 oxiconazole 4.98 14.9 nM 2.43E-6 ergosterol depletion effects on membrane 33 3.14E-7
20 SGTC_1456 k015-0012 4.77 13.0 µM 5.96E-6 14 9.06E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.394 5.99E-125 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.213 8.68E-36 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.212 2.43E-35 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.203 1.88E-32 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.198 3.87E-31 YDR176W NGG1 hom Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
0.191 5.56E-29 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.188 4.93E-28 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.183 1.36E-26 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.182 1.99E-26 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.175 1.42E-24 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.173 7.42E-24 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.172 9.18E-24 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.169 4.90E-23 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.165 8.65E-22 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.163 2.72E-21 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31