YDR294C / DPL1

Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR294C / DPL1

Click on Significant Values for Screen Details ID:SGTC_133|Compound:0724-0033|FD-Score:3.06|P-value:4.47E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.61|P-value:6.60E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-2.96|P-value:8.95E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.85|P-value:1.60E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.72|P-value:2.86E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.62|P-value:4.40E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.21|P-value:3.38E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.28|P-value:1.90E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:32.50|P-value:4.35E-266 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.08|P-value:5.29E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:9.16|P-value:3.37E-23 ID:SGTC_677|Compound:0929-0063|FD-Score:3.34|P-value:1.48E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.13|P-value:3.46E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.54|P-value:6.32E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.63|P-value:6.12E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.11|P-value:5.04E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.74|P-value:2.63E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:4.07|P-value:5.36E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.57|P-value:7.78E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.96|P-value:8.80E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.13|P-value:1.53E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.53|P-value:9.30E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.59|P-value:7.31E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.99|P-value:5.83E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-4.41|P-value:1.41E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.18|P-value:2.88E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.52|P-value:9.85E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.85|P-value:9.88E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.98|P-value:8.22E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.98|P-value:8.09E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.53|P-value:9.34E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-3.07|P-value:5.86E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.01|P-value:7.42E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.08|P-value:4.14E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.08|P-value:5.71E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.98|P-value:1.22E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.40|P-value:1.16E-4 ID:SGTC_2248|Compound:tofa|FD-Score:2.85|P-value:9.87E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.01|P-value:5.46E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.69|P-value:3.25E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.37|P-value:1.81E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.18|P-value:2.81E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.96|P-value:6.55E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.52|P-value:6.93E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.43|P-value:1.03E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.03|P-value:5.10E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.23|P-value:3.11E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.50|P-value:1.06E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.28|P-value:2.60E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.57|P-value:4.02E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:3.06|P-value:4.47E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.61|P-value:6.60E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-2.96|P-value:8.95E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.85|P-value:1.60E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.72|P-value:2.86E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.62|P-value:4.40E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.21|P-value:3.38E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.28|P-value:1.90E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:32.50|P-value:4.35E-266 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.08|P-value:5.29E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:9.16|P-value:3.37E-23 ID:SGTC_677|Compound:0929-0063|FD-Score:3.34|P-value:1.48E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.13|P-value:3.46E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.54|P-value:6.32E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.63|P-value:6.12E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.11|P-value:5.04E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.74|P-value:2.63E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:4.07|P-value:5.36E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.57|P-value:7.78E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.96|P-value:8.80E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.13|P-value:1.53E-8 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.53|P-value:9.30E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.59|P-value:7.31E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.99|P-value:5.83E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-4.41|P-value:1.41E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.18|P-value:2.88E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.52|P-value:9.85E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.85|P-value:9.88E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.98|P-value:8.22E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.98|P-value:8.09E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.53|P-value:9.34E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-3.07|P-value:5.86E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.01|P-value:7.42E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.08|P-value:4.14E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.08|P-value:5.71E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.98|P-value:1.22E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.40|P-value:1.16E-4 ID:SGTC_2248|Compound:tofa|FD-Score:2.85|P-value:9.87E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.01|P-value:5.46E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.69|P-value:3.25E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.37|P-value:1.81E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.18|P-value:2.81E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.96|P-value:6.55E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.52|P-value:6.93E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.43|P-value:1.03E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.03|P-value:5.10E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.23|P-value:3.11E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.50|P-value:1.06E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.28|P-value:2.60E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.57|P-value:4.02E-7

Top fitness defect scores for YDR294C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_438 sphingosine 32.50 6.7 µM 4.35E-266 1 6.79E-232
2 SGTC_669 0108-0021 9.16 26.2 µM 3.37E-23 fatty acid desaturase (OLE1) 7 2.53E-20
3 SGTC_1004 4084-0029 5.13 199.0 µM 1.53E-8 4 1.42E-7
4 SGTC_3331 9141060 4.57 2.0 µM 4.02E-7 cell wall 20 2.44E-6
5 SGTC_457 grayanotoxin iii 4.08 135.0 µM 5.29E-6 60 2.30E-5
6 SGTC_910 3454-3003 4.07 490.0 µM 5.36E-6 12 2.33E-5
7 SGTC_310 1273-0058 3.85 1.1 µM 1.60E-5 mitochondrial stress 252 6.01E-5
8 SGTC_828 2074-0507 3.74 139.0 µM 2.63E-5 RPP1 & pyrimidine depletion 27 9.26E-5
9 SGTC_349 k015-0014 3.72 24.0 µM 2.86E-5 24 9.99E-5
10 SGTC_2309 7664088 3.69 163.9 µM 3.25E-5 45 1.12E-4
11 SGTC_363 0455-0021 3.62 3.1 µM 4.40E-5 azole & statin 79 1.45E-4
12 SGTC_763 3453-1109 3.54 128.0 µM 6.32E-5 32 1.99E-4
13 SGTC_2586 curcumin 3.52 80.0 µM 6.93E-5 iron homeostasis 75 2.16E-4
14 SGTC_2621 lithochol-11-enic acid 3.43 100.0 µM 1.03E-4 45 3.04E-4
15 SGTC_2021 4019055 3.40 173.0 µM 1.16E-4 endomembrane recycling 171 3.38E-4
16 SGTC_677 0929-0063 3.34 136.0 µM 1.48E-4 23 4.17E-4
17 SGTC_374 0880-0231 3.28 82.3 µM 1.90E-4 iron homeostasis 54 5.18E-4
18 SGTC_2416 tofa 3.18 880.0 nM 2.81E-4 sphingolipid biosynthesis & PDR1 88 7.30E-4
19 SGTC_1333 1482-0047 3.18 286.0 µM 2.88E-4 45 7.46E-4
20 SGTC_684 1140-0066 3.13 328.0 µM 3.46E-4 Golgi 72 8.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 3.88E-43 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.190 1.25E-28 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.185 4.10E-27 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.176 9.15E-25 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.158 3.41E-20 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.155 1.90E-19 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.150 1.86E-18 YEL010W_d YEL010W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 6.73E-18 YGR225W AMA1 hom Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
0.146 1.84E-17 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.144 4.95E-17 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.144 5.69E-17 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.143 8.16E-17 YGL057C GEP7 hom Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.134 5.50E-15 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.132 1.34E-14 YML003W_p YML003W_p hom Putative protein of unknown function
0.132 1.37E-14 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds