YDR296W / MHR1

Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR296W / MHR1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.29|P-value:6.39E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.64|P-value:5.73E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.64|P-value:5.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.70|P-value:4.92E-30 ID:SGTC_204|Compound:1543-0184|FD-Score:3.72|P-value:4.48E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.60|P-value:3.25E-34 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.66|P-value:2.24E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:5.23E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.08|P-value:1.49E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.53|P-value:2.94E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.32|P-value:1.20E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.58|P-value:2.61E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.55|P-value:8.44E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.96|P-value:2.27E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.17|P-value:9.87E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.62|P-value:6.12E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.27|P-value:7.65E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:4.48|P-value:3.18E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.68|P-value:5.00E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.07|P-value:3.44E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.82|P-value:3.65E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.19|P-value:8.98E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.93|P-value:2.23E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.53|P-value:9.01E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.74|P-value:4.71E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.47|P-value:9.47E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.69|P-value:4.85E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.96|P-value:2.01E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.79|P-value:3.50E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.07|P-value:1.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.47|P-value:3.77E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.69|P-value:5.36E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.65|P-value:5.51E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.06|P-value:1.45E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.94|P-value:5.22E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.88|P-value:2.95E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.65|P-value:1.67E-5 ID:SGTC_2094|Compound:5332512|FD-Score:4.29|P-value:6.42E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.40|P-value:4.31E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.35|P-value:7.48E-9 ID:SGTC_2297|Compound:7971671|FD-Score:-3.96|P-value:2.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-5.48|P-value:5.95E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:3.94|P-value:2.19E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.57|P-value:7.87E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:3.89|P-value:2.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.66|P-value:5.93E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-4.06|P-value:1.62E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.52|P-value:1.92E-14 ID:SGTC_2995|Compound:9067767|FD-Score:7.06|P-value:1.56E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.10|P-value:1.42E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.65|P-value:1.93E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.67|P-value:5.17E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.29|P-value:6.39E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.64|P-value:5.73E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.64|P-value:5.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.70|P-value:4.92E-30 ID:SGTC_204|Compound:1543-0184|FD-Score:3.72|P-value:4.48E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.60|P-value:3.25E-34 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.66|P-value:2.24E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:7.24|P-value:5.23E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.08|P-value:1.49E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.53|P-value:2.94E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.32|P-value:1.20E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.58|P-value:2.61E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.55|P-value:8.44E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.96|P-value:2.27E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.17|P-value:9.87E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.62|P-value:6.12E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.27|P-value:7.65E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:4.48|P-value:3.18E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.68|P-value:5.00E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.07|P-value:3.44E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.82|P-value:3.65E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.19|P-value:8.98E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.93|P-value:2.23E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.53|P-value:9.01E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.74|P-value:4.71E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.47|P-value:9.47E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.69|P-value:4.85E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.96|P-value:2.01E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.79|P-value:3.50E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.07|P-value:1.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.47|P-value:3.77E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.69|P-value:5.36E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.65|P-value:5.51E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.06|P-value:1.45E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.94|P-value:5.22E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.88|P-value:2.95E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.65|P-value:1.67E-5 ID:SGTC_2094|Compound:5332512|FD-Score:4.29|P-value:6.42E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.40|P-value:4.31E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.35|P-value:7.48E-9 ID:SGTC_2297|Compound:7971671|FD-Score:-3.96|P-value:2.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-5.48|P-value:5.95E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:3.94|P-value:2.19E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.57|P-value:7.87E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:3.89|P-value:2.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.66|P-value:5.93E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-4.06|P-value:1.62E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.52|P-value:1.92E-14 ID:SGTC_2995|Compound:9067767|FD-Score:7.06|P-value:1.56E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.10|P-value:1.42E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.65|P-value:1.93E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.67|P-value:5.17E-4

Top fitness defect scores for YDR296W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.60 5.3 µM 3.25E-34 127 1.33E-42
2 SGTC_173 1273-0061 12.70 2.7 µM 4.92E-30 mitochondrial stress 18 2.47E-37
3 SGTC_310 1273-0058 7.24 1.1 µM 5.23E-11 mitochondrial stress 110 2.17E-13
4 SGTC_2995 9067767 7.06 71.4 µM 1.56E-10 1 8.57E-13
5 SGTC_2250 alverine citrate 6.35 130.0 µM 7.48E-9 45 1.09E-10
6 SGTC_275 trichlorophene 5.66 5.7 µM 2.24E-7 mitochondrial stress 131 7.74E-9
7 SGTC_1922 5578187 4.94 25.0 µM 5.22E-6 TRP & mitochondrial translation 10 3.95E-7
8 SGTC_2087 5276107 4.65 200.0 µM 1.67E-5 9 1.69E-6
9 SGTC_933 2914-0560 4.48 114.0 µM 3.18E-5 18 3.76E-6
10 SGTC_2232 chlorophetanol 4.40 41.5 µM 4.31E-5 TRP & mitochondrial translation 103 5.51E-6
11 SGTC_28 pentachloropyridine N-oxide 4.29 1.6 µM 6.39E-5 TSC3-RPN4 58 8.98E-6
12 SGTC_2094 5332512 4.29 191.7 µM 6.42E-5 18 9.04E-6
13 SGTC_965 1291-5240 4.19 308.0 µM 8.98E-5 27 1.37E-5
14 SGTC_876 0720-0963 4.17 56.8 µM 9.87E-5 10 1.54E-5
15 SGTC_1627 st003713 4.07 25.6 µM 1.40E-4 calcium & mitochondrial duress 69 2.38E-5
16 SGTC_1883 5-benzylidenerhodanine 4.06 20.0 µM 1.45E-4 TRP & mitochondrial translation 66 2.49E-5
17 SGTC_1622 st003707 3.96 19.4 µM 2.01E-4 calcium & mitochondrial duress 37 3.74E-5
18 SGTC_2533 agelasine 3.94 13.7 µM 2.19E-4 ERG2 49 4.16E-5
19 SGTC_967 1306-0166 3.93 352.0 µM 2.23E-4 36 4.25E-5
20 SGTC_2669 eugenol 3.89 100.0 µM 2.52E-4 12 4.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 9.74E-201 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.470 1.25E-183 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.469 3.68E-183 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.463 1.14E-177 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.456 1.54E-171 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.455 2.92E-171 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.451 1.95E-167 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.449 1.51E-166 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.440 7.72E-159 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.437 2.86E-156 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.433 3.01E-153 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.432 1.87E-152 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.430 6.41E-151 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.426 8.22E-148 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.422 2.97E-145 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit