YDR304C / CPR5

Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR304C / CPR5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.02|P-value:1.28E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.46|P-value:1.52E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.31|P-value:2.75E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.09|P-value:5.21E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:5.05|P-value:6.72E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.20|P-value:4.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.91|P-value:2.22E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.76|P-value:4.06E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.67|P-value:6.23E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:3.59|P-value:8.95E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.02|P-value:7.96E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.03|P-value:7.61E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.01|P-value:8.35E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.60|P-value:8.46E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.57|P-value:9.54E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.02|P-value:8.05E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.42|P-value:1.95E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:3.77|P-value:4.02E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.69|P-value:4.87E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.80|P-value:3.52E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.20|P-value:5.71E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.14|P-value:5.12E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.87|P-value:2.61E-5 ID:SGTC_1717|Compound:st033143|FD-Score:5.83|P-value:5.36E-10 ID:SGTC_1731|Compound:st035964|FD-Score:3.09|P-value:6.24E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.01|P-value:8.45E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.97|P-value:9.48E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.06|P-value:1.11E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.53|P-value:1.10E-6 ID:SGTC_1989|Compound:st071868|FD-Score:3.42|P-value:1.80E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.25|P-value:3.47E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.36|P-value:2.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.39|P-value:2.20E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.06|P-value:6.92E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.04|P-value:7.47E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.19|P-value:2.77E-14 ID:SGTC_2412|Compound:st077135|FD-Score:-4.29|P-value:3.49E-6 ID:SGTC_2413|Compound:inermin|FD-Score:7.81|P-value:1.65E-16 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.00|P-value:8.75E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.10|P-value:4.88E-8 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.16|P-value:4.85E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.66|P-value:6.31E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-3.47|P-value:1.40E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-7.14|P-value:3.83E-14 ID:SGTC_2945|Compound:9067681|FD-Score:-4.35|P-value:2.65E-6 ID:SGTC_2946|Compound:9065502|FD-Score:4.83|P-value:2.19E-7 ID:SGTC_3012|Compound:9080433|FD-Score:-3.58|P-value:9.05E-5 ID:SGTC_3109|Compound:9122853|FD-Score:-3.22|P-value:3.69E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.02|P-value:1.28E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:3.46|P-value:1.52E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.31|P-value:2.75E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.09|P-value:5.21E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:5.05|P-value:6.72E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.20|P-value:4.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.91|P-value:2.22E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.76|P-value:4.06E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.67|P-value:6.23E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:3.59|P-value:8.95E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.02|P-value:7.96E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.03|P-value:7.61E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.01|P-value:8.35E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.60|P-value:8.46E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.57|P-value:9.54E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.02|P-value:8.05E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.42|P-value:1.95E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:3.77|P-value:4.02E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.69|P-value:4.87E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.80|P-value:3.52E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.20|P-value:5.71E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.14|P-value:5.12E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.87|P-value:2.61E-5 ID:SGTC_1717|Compound:st033143|FD-Score:5.83|P-value:5.36E-10 ID:SGTC_1731|Compound:st035964|FD-Score:3.09|P-value:6.24E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.01|P-value:8.45E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.97|P-value:9.48E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.06|P-value:1.11E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.53|P-value:1.10E-6 ID:SGTC_1989|Compound:st071868|FD-Score:3.42|P-value:1.80E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.25|P-value:3.47E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.36|P-value:2.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.39|P-value:2.20E-6 ID:SGTC_2133|Compound:5320837|FD-Score:3.06|P-value:6.92E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.04|P-value:7.47E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.19|P-value:2.77E-14 ID:SGTC_2412|Compound:st077135|FD-Score:-4.29|P-value:3.49E-6 ID:SGTC_2413|Compound:inermin|FD-Score:7.81|P-value:1.65E-16 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.00|P-value:8.75E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.10|P-value:4.88E-8 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.16|P-value:4.85E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.66|P-value:6.31E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-3.47|P-value:1.40E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-7.14|P-value:3.83E-14 ID:SGTC_2945|Compound:9067681|FD-Score:-4.35|P-value:2.65E-6 ID:SGTC_2946|Compound:9065502|FD-Score:4.83|P-value:2.19E-7 ID:SGTC_3012|Compound:9080433|FD-Score:-3.58|P-value:9.05E-5 ID:SGTC_3109|Compound:9122853|FD-Score:-3.22|P-value:3.69E-4

Top fitness defect scores for YDR304C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2413 inermin 7.81 26.1 µM 1.65E-16 8 2.91E-15
2 SGTC_2409 alverine citrate 7.19 64.0 µM 2.77E-14 13 3.17E-13
3 SGTC_1717 st033143 5.83 58.0 µM 5.36E-10 13 2.69E-9
4 SGTC_2689 tacrolimus 5.10 100.0 µM 4.88E-8 22 1.69E-7
5 SGTC_143 4032-1194 5.09 15.7 µM 5.21E-8 29 1.79E-7
6 SGTC_145 3737-0113 5.05 38.4 µM 6.72E-8 DNA intercalators 43 2.26E-7
7 SGTC_2946 9065502 4.83 71.4 µM 2.19E-7 4 6.68E-7
8 SGTC_1128 3448-9350 4.69 235.0 µM 4.87E-7 15 1.39E-6
9 SGTC_1966 st070145 4.53 16.1 µM 1.10E-6 17 2.93E-6
10 SGTC_829 1635-0120 4.42 117.0 µM 1.95E-6 DNA damage response 30 4.99E-6
11 SGTC_2126 5251174 4.39 33.9 µM 2.20E-6 18 5.56E-6
12 SGTC_1356 1502-0781 4.20 85.8 µM 5.71E-6 fatty acid desaturase (OLE1) 11 1.34E-5
13 SGTC_1887 st057648 4.06 70.8 µM 1.11E-5 11 2.47E-5
14 SGTC_264 promethazine 3.91 12.5 mM 2.22E-5 DNA intercalators 55 4.66E-5
15 SGTC_1437 4092-1038 3.87 11.6 µM 2.61E-5 18 5.40E-5
16 SGTC_1133 3473-0247 3.80 50.0 µM 3.52E-5 RSC complex & mRNA processing 57 7.11E-5
17 SGTC_921 1561-0023 3.77 372.0 µM 4.02E-5 18 8.02E-5
18 SGTC_332 4112-0506 3.67 40.9 µM 6.23E-5 32 1.20E-4
19 SGTC_729 4092-0585 3.60 94.1 µM 8.46E-5 35 1.59E-4
20 SGTC_338 4055-0136 3.59 114.0 µM 8.95E-5 17 1.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.35E-33 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.204 5.04E-33 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.172 8.58E-24 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.162 2.86E-21 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 7.73E-18 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.145 2.75E-17 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.139 7.29E-16 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.136 3.01E-15 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 5.35E-15 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.133 9.21E-15 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.124 4.70E-13 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.122 1.43E-12 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.117 9.62E-12 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.114 3.47E-11 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.113 4.53E-11 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3