YDR306C_p

F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR306C / YDR306C

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:-3.60|P-value:3.65E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.63|P-value:7.31E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.35|P-value:8.83E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.86|P-value:1.56E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.55|P-value:4.27E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.63|P-value:3.41E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.28|P-value:3.10E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.66|P-value:3.08E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.75|P-value:2.24E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.52|P-value:5.03E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:5.26|P-value:4.40E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.33|P-value:8.86E-4 ID:SGTC_1563|Compound:conessine|FD-Score:9.06|P-value:1.12E-17 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.83|P-value:1.70E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:6.80|P-value:9.65E-11 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:10.50|P-value:4.07E-23 ID:SGTC_1608|Compound:st001473|FD-Score:-3.83|P-value:1.60E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.17|P-value:4.76E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.39|P-value:7.75E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.87|P-value:2.43E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.56|P-value:4.35E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.00|P-value:8.55E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.99|P-value:9.40E-5 ID:SGTC_2284|Compound:7945075|FD-Score:5.50|P-value:1.35E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.51|P-value:5.14E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.86|P-value:1.56E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.23|P-value:3.53E-5 ID:SGTC_2681|Compound:menadione|FD-Score:4.57|P-value:9.68E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-4.43|P-value:1.61E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-4.54|P-value:1.00E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.67|P-value:2.80E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.00|P-value:9.19E-5 ID:SGTC_3068|Compound:9116768|FD-Score:4.01|P-value:8.78E-5 ID:SGTC_3162|Compound:9099653|FD-Score:-3.81|P-value:1.73E-4 ID:SGTC_3168|Compound:9103419|FD-Score:4.38|P-value:2.09E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.84|P-value:1.55E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.76|P-value:4.29E-6 ID:SGTC_3323|Compound:9138564|FD-Score:5.44|P-value:1.79E-7 ID:SGTC_3324|Compound:9138759|FD-Score:5.64|P-value:6.58E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-3.71|P-value:2.42E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.60|P-value:3.65E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.63|P-value:7.31E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.35|P-value:8.83E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.86|P-value:1.56E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.55|P-value:4.27E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.63|P-value:3.41E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:4.28|P-value:3.10E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.66|P-value:3.08E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.75|P-value:2.24E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.52|P-value:5.03E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:5.26|P-value:4.40E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.33|P-value:8.86E-4 ID:SGTC_1563|Compound:conessine|FD-Score:9.06|P-value:1.12E-17 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.83|P-value:1.70E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:6.80|P-value:9.65E-11 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:10.50|P-value:4.07E-23 ID:SGTC_1608|Compound:st001473|FD-Score:-3.83|P-value:1.60E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.17|P-value:4.76E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.39|P-value:7.75E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.87|P-value:2.43E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.56|P-value:4.35E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.00|P-value:8.55E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.99|P-value:9.40E-5 ID:SGTC_2284|Compound:7945075|FD-Score:5.50|P-value:1.35E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.51|P-value:5.14E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.86|P-value:1.56E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.23|P-value:3.53E-5 ID:SGTC_2681|Compound:menadione|FD-Score:4.57|P-value:9.68E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-4.43|P-value:1.61E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-4.54|P-value:1.00E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.67|P-value:2.80E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.00|P-value:9.19E-5 ID:SGTC_3068|Compound:9116768|FD-Score:4.01|P-value:8.78E-5 ID:SGTC_3162|Compound:9099653|FD-Score:-3.81|P-value:1.73E-4 ID:SGTC_3168|Compound:9103419|FD-Score:4.38|P-value:2.09E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.84|P-value:1.55E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.76|P-value:4.29E-6 ID:SGTC_3323|Compound:9138564|FD-Score:5.44|P-value:1.79E-7 ID:SGTC_3324|Compound:9138759|FD-Score:5.64|P-value:6.58E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-3.71|P-value:2.42E-4

Top fitness defect scores for YDR306C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1572 epiandrosterone 10.50 68.9 µM 4.07E-23 7 4.24E-26
2 SGTC_1563 conessine 9.06 56.1 µM 1.12E-17 1 6.60E-20
3 SGTC_1569 carminic acid 6.80 40.6 µM 9.65E-11 2 5.12E-12
4 SGTC_3324 9138759 5.64 60.8 µM 6.58E-8 4 8.52E-9
5 SGTC_2284 7945075 5.50 39.2 µM 1.35E-7 mitochondrial processes 6 1.93E-8
6 SGTC_3323 9138564 5.44 53.9 µM 1.79E-7 3 2.66E-8
7 SGTC_1300 1094-0077 5.26 113.0 µM 4.40E-7 3 7.36E-8
8 SGTC_3313 9133968 4.76 57.0 µM 4.29E-6 3 9.78E-7
9 SGTC_114 0364-0001 4.63 490.3 µM 7.31E-6 24 1.79E-6
10 SGTC_2681 menadione 4.57 3.2 µM 9.68E-6 superoxide 24 2.46E-6
11 SGTC_3168 9103419 4.38 49.5 µM 2.09E-5 60S ribosome export 5 5.90E-6
12 SGTC_848 0368-0089 4.28 85.6 µM 3.10E-5 iron homeostasis 8 9.24E-6
13 SGTC_1777 st045864 4.17 34.8 µM 4.76E-5 7 1.50E-5
14 SGTC_3068 9116768 4.01 49.5 µM 8.78E-5 18 3.00E-5
15 SGTC_2980 9014342 4.00 25.3 µM 9.19E-5 33 3.16E-5
16 SGTC_2280 7785178 3.99 200.0 µM 9.40E-5 10 3.24E-5
17 SGTC_2552 juarezic acid 3.86 87.0 µM 1.56E-4 TSC3-RPN4 41 5.74E-5
18 SGTC_122 0236-0016 3.86 402.4 µM 1.56E-4 RNA processing & uracil transport 35 5.76E-5
19 SGTC_1769 st044406 3.84 64.4 µM 1.64E-4 18 6.09E-5
20 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.83 85.4 µM 1.70E-4 25 6.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 7.93E-41 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.216 7.24E-37 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.175 1.63E-24 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.173 5.52E-24 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.151 1.13E-18 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.149 3.82E-18 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.147 1.41E-17 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.145 2.38E-17 YLR287C_p YLR287C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
0.145 2.60E-17 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.140 4.04E-16 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.135 3.93E-15 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.44E-13 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.126 2.67E-13 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.118 6.17E-12 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.116 1.69E-11 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis