YDR307W_p / PMT7

Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR307W / PMT7

Click on Significant Values for Screen Details ID:SGTC_228|Compound:caffeine|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.75|P-value:5.12E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.04|P-value:7.95E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.18|P-value:7.46E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.43|P-value:1.94E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.02|P-value:8.69E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-2.98|P-value:9.75E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.88|P-value:2.87E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.91|P-value:2.56E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:3.13|P-value:5.88E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.78|P-value:4.50E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.07|P-value:7.41E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.63|P-value:8.11E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.44|P-value:2.11E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:2.99|P-value:9.86E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.03|P-value:1.49E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.69|P-value:5.69E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.23|P-value:4.15E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.76|P-value:4.91E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.85|P-value:3.33E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.10|P-value:1.09E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.99|P-value:9.81E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-5.38|P-value:1.18E-8 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.17|P-value:5.13E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.90|P-value:2.53E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.23|P-value:4.12E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.43|P-value:1.92E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.54|P-value:1.24E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.08|P-value:7.10E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.99|P-value:1.81E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-4.04|P-value:1.34E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.24|P-value:5.71E-6 ID:SGTC_2030|Compound:5175110|FD-Score:4.47|P-value:1.80E-6 ID:SGTC_2108|Compound:5365811|FD-Score:-3.13|P-value:5.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.60|P-value:9.46E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.68|P-value:1.90E-9 ID:SGTC_2394|Compound:5221648|FD-Score:3.42|P-value:1.99E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.16|P-value:5.40E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.10|P-value:6.72E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.21|P-value:4.46E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.28|P-value:3.39E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.26|P-value:3.62E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.25|P-value:3.71E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.15|P-value:5.32E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.80|P-value:3.98E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.73|P-value:5.50E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-4.97|P-value:1.27E-7 ID:SGTC_2991|Compound:9074669|FD-Score:4.19|P-value:7.02E-6 ID:SGTC_3154|Compound:9100113|FD-Score:3.04|P-value:8.35E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-8.80|P-value:3.51E-20 ID:SGTC_3206|Compound:9114350|FD-Score:-4.76|P-value:3.90E-7 ID:SGTC_3208|Compound:9114115|FD-Score:-4.19|P-value:6.87E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.25|P-value:3.86E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.09|P-value:6.90E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.75|P-value:5.12E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.04|P-value:7.95E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.18|P-value:7.46E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:3.43|P-value:1.94E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.02|P-value:8.69E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-2.98|P-value:9.75E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.88|P-value:2.87E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.91|P-value:2.56E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:3.13|P-value:5.88E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.78|P-value:4.50E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.07|P-value:7.41E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.63|P-value:8.11E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.44|P-value:2.11E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:2.99|P-value:9.86E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.03|P-value:1.49E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.69|P-value:5.69E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.23|P-value:4.15E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.76|P-value:4.91E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.85|P-value:3.33E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.10|P-value:1.09E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.99|P-value:9.81E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-5.38|P-value:1.18E-8 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.17|P-value:5.13E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.90|P-value:2.53E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.23|P-value:4.12E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.43|P-value:1.92E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.54|P-value:1.24E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.08|P-value:7.10E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.99|P-value:1.81E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-4.04|P-value:1.34E-5 ID:SGTC_1903|Compound:st060211|FD-Score:4.24|P-value:5.71E-6 ID:SGTC_2030|Compound:5175110|FD-Score:4.47|P-value:1.80E-6 ID:SGTC_2108|Compound:5365811|FD-Score:-3.13|P-value:5.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.60|P-value:9.46E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.68|P-value:1.90E-9 ID:SGTC_2394|Compound:5221648|FD-Score:3.42|P-value:1.99E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.16|P-value:5.40E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.10|P-value:6.72E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.21|P-value:4.46E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.28|P-value:3.39E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.26|P-value:3.62E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.25|P-value:3.71E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.15|P-value:5.32E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.80|P-value:3.98E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.73|P-value:5.50E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.48|P-value:1.59E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-4.97|P-value:1.27E-7 ID:SGTC_2991|Compound:9074669|FD-Score:4.19|P-value:7.02E-6 ID:SGTC_3154|Compound:9100113|FD-Score:3.04|P-value:8.35E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-8.80|P-value:3.51E-20 ID:SGTC_3206|Compound:9114350|FD-Score:-4.76|P-value:3.90E-7 ID:SGTC_3208|Compound:9114115|FD-Score:-4.19|P-value:6.87E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.25|P-value:3.86E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.09|P-value:6.90E-4

Top fitness defect scores for YDR307W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2030 5175110 4.47 200.0 µM 1.80E-6 Golgi 19 3.87E-6
2 SGTC_940 3232-1287 4.44 54.8 µM 2.11E-6 NEO1 23 4.48E-6
3 SGTC_1903 st060211 4.24 78.3 µM 5.71E-6 20 1.14E-5
4 SGTC_2991 9074669 4.19 71.4 µM 7.02E-6 azole & statin 49 1.38E-5
5 SGTC_604 1000-0114 4.18 314.0 µM 7.46E-6 14 1.46E-5
6 SGTC_1193 1488-0126 4.10 41.5 µM 1.09E-5 22 2.08E-5
7 SGTC_1122 capsaicin 4.03 818.6 nM 1.49E-5 26 2.78E-5
8 SGTC_1633 st005664 3.99 67.9 µM 1.81E-5 28 3.33E-5
9 SGTC_746 1095-0025 3.91 46.6 µM 2.56E-5 RSC & ERG11 15 4.62E-5
10 SGTC_701 4424-0219 3.88 185.0 µM 2.87E-5 calcium & mitochondrial duress 19 5.13E-5
11 SGTC_1174 0739-0097 3.85 51.1 µM 3.33E-5 redox potentiating 37 5.89E-5
12 SGTC_893 0958-0369 3.78 48.9 µM 4.50E-5 30 7.81E-5
13 SGTC_1433 4060-0023 3.77 7.6 µM 4.79E-5 tubulin folding & SWR complex 24 8.28E-5
14 SGTC_1150 3909-7983 3.76 10.9 µM 4.91E-5 32 8.48E-5
15 SGTC_292 k038-0015 3.75 474.0 µM 5.12E-5 9 8.82E-5
16 SGTC_2978 9011784 3.73 43.0 µM 5.50E-5 38 9.42E-5
17 SGTC_1416 3966-0321 3.54 25.3 µM 1.24E-4 31 2.01E-4
18 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 3.51 61.8 µM 1.42E-4 ergosterol biosynthesis 17 2.28E-4
19 SGTC_2980 9014342 3.48 25.3 µM 1.59E-4 54 2.54E-4
20 SGTC_1394 3474-0001 3.43 65.7 µM 1.92E-4 endomembrane recycling 57 3.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.65E-19 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.130 4.40E-14 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.123 8.87E-13 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.122 1.15E-12 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.116 1.62E-11 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.109 2.45E-10 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.107 5.20E-10 YDR109C_p YDR109C_p hom Putative kinase
0.106 8.40E-10 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.104 1.50E-9 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.102 5.37E-9 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.093 6.41E-8 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.092 8.69E-8 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.092 9.53E-8 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.090 1.87E-7 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.089 2.27E-7 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p