YDR314C / RAD34

Protein involved in nucleotide excision repair (NER); homologous to RAD4

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR314C / RAD34

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-2.84|P-value:8.23E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.22|P-value:1.84E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.58|P-value:7.03E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.60|P-value:6.53E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.16|P-value:4.10E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.05|P-value:6.09E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:-2.86|P-value:7.46E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:2.98|P-value:7.91E-4 ID:SGTC_264|Compound:promethazine|FD-Score:5.56|P-value:1.35E-9 ID:SGTC_318|Compound:1488-0629|FD-Score:2.99|P-value:7.67E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-2.87|P-value:7.26E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.17|P-value:2.27E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.53|P-value:9.04E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.76|P-value:3.25E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.97|P-value:4.97E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.97|P-value:4.97E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-2.89|P-value:6.74E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:-2.82|P-value:8.85E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:2.92|P-value:9.97E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.79|P-value:1.60E-7 ID:SGTC_1519|Compound:esterone|FD-Score:4.29|P-value:2.41E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.05|P-value:3.72E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.54|P-value:4.74E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.12|P-value:4.65E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.65|P-value:5.24E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.25|P-value:2.87E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.17|P-value:3.84E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.51|P-value:9.71E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.88|P-value:9.41E-8 ID:SGTC_2424|Compound:5537928|FD-Score:-3.17|P-value:2.30E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.12|P-value:4.83E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.19|P-value:3.59E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.19|P-value:2.12E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.82|P-value:1.28E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-5.66|P-value:2.74E-10 ID:SGTC_2970|Compound:9090938|FD-Score:3.34|P-value:2.01E-4 ID:SGTC_3055|Compound:9094636|FD-Score:4.26|P-value:2.84E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.93|P-value:7.50E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-5.84|P-value:7.91E-11 ID:SGTC_37|Compound:0566-0070|FD-Score:-2.84|P-value:8.23E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.22|P-value:1.84E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.58|P-value:7.03E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.60|P-value:6.53E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.16|P-value:4.10E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.05|P-value:6.09E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:-2.86|P-value:7.46E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:2.98|P-value:7.91E-4 ID:SGTC_264|Compound:promethazine|FD-Score:5.56|P-value:1.35E-9 ID:SGTC_318|Compound:1488-0629|FD-Score:2.99|P-value:7.67E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-2.87|P-value:7.26E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.17|P-value:2.27E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.53|P-value:9.04E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.76|P-value:3.25E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.97|P-value:4.97E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.97|P-value:4.97E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-2.89|P-value:6.74E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:-2.82|P-value:8.85E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:2.92|P-value:9.97E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.79|P-value:1.60E-7 ID:SGTC_1519|Compound:esterone|FD-Score:4.29|P-value:2.41E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.05|P-value:3.72E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.54|P-value:4.74E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.12|P-value:4.65E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.65|P-value:5.24E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.25|P-value:2.87E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.17|P-value:3.84E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.51|P-value:9.71E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.88|P-value:9.41E-8 ID:SGTC_2424|Compound:5537928|FD-Score:-3.17|P-value:2.30E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.12|P-value:4.83E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.19|P-value:3.59E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.19|P-value:2.12E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.82|P-value:1.28E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-5.66|P-value:2.74E-10 ID:SGTC_2970|Compound:9090938|FD-Score:3.34|P-value:2.01E-4 ID:SGTC_3055|Compound:9094636|FD-Score:4.26|P-value:2.84E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.93|P-value:7.50E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-5.84|P-value:7.91E-11

Top fitness defect scores for YDR314C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 5.56 12.5 mM 1.35E-9 DNA intercalators 24 1.34E-8
2 SGTC_2309 7664088 4.88 163.9 µM 9.41E-8 11 5.34E-7
3 SGTC_1515 3460-0031 4.79 42.1 µM 1.60E-7 DNA intercalators 9 8.48E-7
4 SGTC_1519 esterone 4.29 74.0 µM 2.41E-6 DNA intercalators 13 8.96E-6
5 SGTC_3055 9094636 4.26 49.5 µM 2.84E-6 5 1.03E-5
6 SGTC_780 0109-0199 3.76 192.0 µM 3.25E-5 19 8.65E-5
7 SGTC_1613 st002381 3.65 52.1 µM 5.24E-5 29 1.31E-4
8 SGTC_108 0509-0257 3.60 621.1 µM 6.53E-5 66 1.59E-4
9 SGTC_105 0111-0055 3.58 734.8 µM 7.03E-5 13 1.70E-4
10 SGTC_775 4577-0580 3.53 57.3 µM 9.04E-5 13 2.12E-4
11 SGTC_1926 methyl fluorone black 3.51 53.6 µM 9.71E-5 DNA intercalators 78 2.25E-4
12 SGTC_2970 9090938 3.34 41.9 µM 2.01E-4 RNA processing & uracil transport 78 4.26E-4
13 SGTC_1705 st027868 3.25 56.3 µM 2.87E-4 28 5.83E-4
14 SGTC_2586 curcumin 3.19 80.0 µM 3.59E-4 iron homeostasis 96 7.09E-4
15 SGTC_1789 tunicamycin 3.17 25.0 nM 3.84E-4 unfolded protein response 95 7.53E-4
16 SGTC_143 4032-1194 3.16 15.7 µM 4.10E-4 120 7.97E-4
17 SGTC_1611 st001856 3.12 99.4 µM 4.65E-4 55 8.90E-4
18 SGTC_2461 5755302 3.12 26.1 µM 4.83E-4 72 9.19E-4
19 SGTC_145 3737-0113 3.05 38.4 µM 6.09E-4 DNA intercalators 125 0.00113
20 SGTC_318 1488-0629 2.99 67.2 µM 7.67E-4 copper-dependent oxidative stress 60 0.00138

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 9.44E-47 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.228 1.10E-40 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.219 9.26E-38 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.213 1.65E-35 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.196 2.24E-30 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.195 3.63E-30 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.195 5.30E-30 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.186 1.40E-27 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.186 1.92E-27 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.169 5.09E-23 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.161 6.99E-21 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.158 2.94E-20 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.158 5.58E-20 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.157 5.12E-20 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.155 2.67E-19 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene