YDR315C / IPK1

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR315C / IPK1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.75|P-value:7.30E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:11.70|P-value:4.18E-24 ID:SGTC_263|Compound:alizarin|FD-Score:4.66|P-value:3.65E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.68|P-value:5.98E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:-4.01|P-value:2.12E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.91|P-value:4.54E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:4.09|P-value:2.52E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.73|P-value:7.82E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.64|P-value:6.65E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.30|P-value:1.29E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.15|P-value:2.09E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-5.19|P-value:2.72E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.74|P-value:7.60E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.79|P-value:6.47E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.98|P-value:3.62E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:29.90|P-value:3.20E-147 ID:SGTC_1246|Compound:0422-0085|FD-Score:8.83|P-value:1.77E-14 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.52|P-value:5.94E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.85|P-value:5.49E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.87|P-value:5.09E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.56|P-value:8.54E-4 ID:SGTC_1563|Compound:conessine|FD-Score:5.78|P-value:3.92E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.71|P-value:3.04E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.26|P-value:1.46E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.85|P-value:5.47E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.80|P-value:4.08E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.55|P-value:5.39E-5 ID:SGTC_1766|Compound:st045414|FD-Score:-3.89|P-value:3.09E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.54|P-value:1.13E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.83|P-value:3.69E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.85|P-value:1.81E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-4.27|P-value:8.75E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.42|P-value:1.83E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.82|P-value:3.88E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:16.20|P-value:1.33E-44 ID:SGTC_2791|Compound:5663188|FD-Score:-3.83|P-value:3.74E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.73|P-value:7.75E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.61|P-value:7.73E-9 ID:SGTC_2956|Compound:9076196|FD-Score:4.68|P-value:3.41E-5 ID:SGTC_2961|Compound:9083290|FD-Score:4.68|P-value:3.40E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.08|P-value:2.62E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.52|P-value:9.51E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.75|P-value:7.30E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:11.70|P-value:4.18E-24 ID:SGTC_263|Compound:alizarin|FD-Score:4.66|P-value:3.65E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.68|P-value:5.98E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:-4.01|P-value:2.12E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.91|P-value:4.54E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:4.09|P-value:2.52E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.73|P-value:7.82E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.64|P-value:6.65E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.30|P-value:1.29E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.15|P-value:2.09E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-5.19|P-value:2.72E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.74|P-value:7.60E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.79|P-value:6.47E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.98|P-value:3.62E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:29.90|P-value:3.20E-147 ID:SGTC_1246|Compound:0422-0085|FD-Score:8.83|P-value:1.77E-14 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.52|P-value:5.94E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.85|P-value:5.49E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.87|P-value:5.09E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.56|P-value:8.54E-4 ID:SGTC_1563|Compound:conessine|FD-Score:5.78|P-value:3.92E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.71|P-value:3.04E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.26|P-value:1.46E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.85|P-value:5.47E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.80|P-value:4.08E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.55|P-value:5.39E-5 ID:SGTC_1766|Compound:st045414|FD-Score:-3.89|P-value:3.09E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.54|P-value:1.13E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.83|P-value:3.69E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.85|P-value:1.81E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-4.27|P-value:8.75E-5 ID:SGTC_2322|Compound:7413319|FD-Score:5.42|P-value:1.83E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.82|P-value:3.88E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:16.20|P-value:1.33E-44 ID:SGTC_2791|Compound:5663188|FD-Score:-3.83|P-value:3.74E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.73|P-value:7.75E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.61|P-value:7.73E-9 ID:SGTC_2956|Compound:9076196|FD-Score:4.68|P-value:3.41E-5 ID:SGTC_2961|Compound:9083290|FD-Score:4.68|P-value:3.40E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.08|P-value:2.62E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.52|P-value:9.51E-4

Top fitness defect scores for YDR315C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1121 fusaric acid 29.90 630.5 nM 3.20E-147 1 5.07E-197
2 SGTC_2615 purpurogallin-4-carboxylic acid 16.20 100.0 µM 1.33E-44 redox potentiating 3 1.92E-59
3 SGTC_255 tunicamycin 11.70 200.5 nM 4.18E-24 unfolded protein response 10 6.11E-32
4 SGTC_1246 0422-0085 8.83 105.0 µM 1.77E-14 2 5.12E-19
5 SGTC_2858 9025781 6.61 9.0 µM 7.73E-9 sphingolipid biosynthesis & PDR1 39 1.90E-11
6 SGTC_1563 conessine 5.78 56.1 µM 3.92E-7 2 3.68E-9
7 SGTC_1789 tunicamycin 5.54 25.0 nM 1.13E-6 unfolded protein response 21 1.51E-8
8 SGTC_2322 7413319 5.42 38.2 µM 1.83E-6 ERAD & cell cycle 77 2.91E-8
9 SGTC_1999 st074831 4.85 12.5 µM 1.81E-5 plasma membrane duress 16 6.27E-7
10 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 4.71 85.4 µM 3.04E-5 13 1.25E-6
11 SGTC_2961 9083290 4.68 32.5 µM 3.40E-5 10 1.46E-6
12 SGTC_2956 9076196 4.68 2.5 µM 3.41E-5 8 1.46E-6
13 SGTC_263 alizarin 4.66 107.9 µM 3.65E-5 iron homeostasis 41 1.60E-6
14 SGTC_1718 roemerine 4.55 11.9 µM 5.39E-5 redox potentiating 30 2.70E-6
15 SGTC_1257 0669-0121 4.52 16.0 µM 5.94E-5 15 3.08E-6
16 SGTC_805 3852-0218 4.30 479.0 µM 1.29E-4 ERAD & cell cycle 57 8.72E-6
17 SGTC_1571 st070080 4.26 73.4 µM 1.46E-4 8 1.03E-5
18 SGTC_922 1866-0035 4.15 480.0 µM 2.09E-4 excess fatty acid 48 1.66E-5
19 SGTC_677 0929-0063 4.09 136.0 µM 2.52E-4 14 2.13E-5
20 SGTC_2962 9082311 4.08 13.2 µM 2.62E-4 18 2.24E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.361 5.28E-104 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.344 8.62E-94 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.340 2.76E-91 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.311 5.80E-76 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.216 8.85E-37 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.206 1.81E-33 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.166 4.15E-22 YDR173C ARG82 hom Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
0.159 2.46E-20 YGL159W_p YGL159W_p hom Putative protein of unknown function; deletion mutant has no detectable phenotype
0.157 6.37E-20 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.155 1.71E-19 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.153 4.29E-19 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.153 5.26E-19 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.149 3.90E-18 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.138 1.14E-15 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.135 4.78E-15 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication