YDR317W / HIM1

Protein of unknown function involved in DNA repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR317W / HIM1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:6.01|P-value:4.50E-11 ID:SGTC_16|Compound:erodoxin|FD-Score:4.27|P-value:1.93E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:3.11|P-value:3.85E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.05|P-value:4.79E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.78|P-value:2.15E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.39|P-value:1.07E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.10|P-value:4.54E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-5.31|P-value:5.82E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:2.89|P-value:8.86E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.58|P-value:5.32E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.73|P-value:3.84E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.25|P-value:7.65E-12 ID:SGTC_486|Compound:niguldipine|FD-Score:6.38|P-value:2.92E-12 ID:SGTC_515|Compound:4092-1064|FD-Score:4.02|P-value:6.95E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.96|P-value:7.62E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.31|P-value:1.95E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:2.98|P-value:6.29E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:2.94|P-value:7.25E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.36|P-value:1.24E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.98|P-value:9.67E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:7.96|P-value:4.63E-18 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.56|P-value:6.76E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.01|P-value:6.29E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.98|P-value:7.12E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.56|P-value:5.81E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.11|P-value:3.78E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.55|P-value:6.99E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.32|P-value:1.78E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.18|P-value:2.85E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.31|P-value:5.01E-9 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.67|P-value:3.70E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:2.98|P-value:6.29E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:9.31|P-value:5.18E-24 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.23|P-value:2.40E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.05|P-value:4.86E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.04|P-value:6.23E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.28|P-value:2.22E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.48|P-value:8.52E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.58|P-value:5.45E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.50|P-value:5.70E-7 ID:SGTC_1800|Compound:st050079|FD-Score:5.05|P-value:2.52E-8 ID:SGTC_1803|Compound:st050068|FD-Score:4.56|P-value:4.13E-7 ID:SGTC_1818|Compound:st052136|FD-Score:4.11|P-value:4.39E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.64|P-value:4.20E-5 ID:SGTC_1963|Compound:st076565|FD-Score:-3.47|P-value:1.02E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.79|P-value:2.12E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.39|P-value:2.96E-9 ID:SGTC_2049|Compound:5262831|FD-Score:-3.25|P-value:2.50E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.29|P-value:1.88E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.48|P-value:8.34E-5 ID:SGTC_2202|Compound:7226349|FD-Score:-2.94|P-value:8.04E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.21|P-value:9.45E-9 ID:SGTC_2378|Compound:9074213|FD-Score:-4.09|P-value:5.61E-6 ID:SGTC_2398|Compound:5228213|FD-Score:6.85|P-value:7.07E-14 ID:SGTC_2487|Compound:5918373|FD-Score:2.88|P-value:9.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.91|P-value:8.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.74|P-value:3.50E-10 ID:SGTC_2602|Compound:kawain|FD-Score:2.94|P-value:7.18E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.05|P-value:4.87E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-2.93|P-value:8.53E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.66|P-value:5.07E-10 ID:SGTC_2694|Compound:st077685|FD-Score:-3.94|P-value:1.17E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.67|P-value:4.23E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.53|P-value:7.60E-5 ID:SGTC_2807|Compound:7945238|FD-Score:2.97|P-value:6.42E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.35|P-value:1.43E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.44|P-value:1.12E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.33|P-value:1.74E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.01|P-value:6.28E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-5.27|P-value:7.54E-9 ID:SGTC_3153|Compound:9100258|FD-Score:-3.83|P-value:2.02E-5 ID:SGTC_3228|Compound:9131799|FD-Score:-3.06|P-value:5.19E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.12|P-value:4.16E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.09|P-value:4.65E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.01|P-value:4.50E-11 ID:SGTC_16|Compound:erodoxin|FD-Score:4.27|P-value:1.93E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:3.11|P-value:3.85E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.05|P-value:4.79E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.78|P-value:2.15E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.39|P-value:1.07E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.10|P-value:4.54E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-5.31|P-value:5.82E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:2.89|P-value:8.86E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.58|P-value:5.32E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.73|P-value:3.84E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.25|P-value:7.65E-12 ID:SGTC_486|Compound:niguldipine|FD-Score:6.38|P-value:2.92E-12 ID:SGTC_515|Compound:4092-1064|FD-Score:4.02|P-value:6.95E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-2.96|P-value:7.62E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.31|P-value:1.95E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:2.98|P-value:6.29E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:2.94|P-value:7.25E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.36|P-value:1.24E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.98|P-value:9.67E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:7.96|P-value:4.63E-18 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.56|P-value:6.76E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.01|P-value:6.29E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-2.98|P-value:7.12E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.56|P-value:5.81E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.11|P-value:3.78E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.55|P-value:6.99E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.32|P-value:1.78E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.18|P-value:2.85E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.31|P-value:5.01E-9 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.67|P-value:3.70E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:2.98|P-value:6.29E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:9.31|P-value:5.18E-24 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.23|P-value:2.40E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.05|P-value:4.86E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.04|P-value:6.23E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.28|P-value:2.22E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.48|P-value:8.52E-5 ID:SGTC_1697|Compound:st025554|FD-Score:3.58|P-value:5.45E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.41|P-value:1.14E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.50|P-value:5.70E-7 ID:SGTC_1800|Compound:st050079|FD-Score:5.05|P-value:2.52E-8 ID:SGTC_1803|Compound:st050068|FD-Score:4.56|P-value:4.13E-7 ID:SGTC_1818|Compound:st052136|FD-Score:4.11|P-value:4.39E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.64|P-value:4.20E-5 ID:SGTC_1963|Compound:st076565|FD-Score:-3.47|P-value:1.02E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.79|P-value:2.12E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.39|P-value:2.96E-9 ID:SGTC_2049|Compound:5262831|FD-Score:-3.25|P-value:2.50E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.29|P-value:1.88E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.48|P-value:8.34E-5 ID:SGTC_2202|Compound:7226349|FD-Score:-2.94|P-value:8.04E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.21|P-value:9.45E-9 ID:SGTC_2378|Compound:9074213|FD-Score:-4.09|P-value:5.61E-6 ID:SGTC_2398|Compound:5228213|FD-Score:6.85|P-value:7.07E-14 ID:SGTC_2487|Compound:5918373|FD-Score:2.88|P-value:9.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.91|P-value:8.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.74|P-value:3.50E-10 ID:SGTC_2602|Compound:kawain|FD-Score:2.94|P-value:7.18E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.05|P-value:4.87E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-2.93|P-value:8.53E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.66|P-value:5.07E-10 ID:SGTC_2694|Compound:st077685|FD-Score:-3.94|P-value:1.17E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.67|P-value:4.23E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.53|P-value:7.60E-5 ID:SGTC_2807|Compound:7945238|FD-Score:2.97|P-value:6.42E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.35|P-value:1.43E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.44|P-value:1.12E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.33|P-value:1.74E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.01|P-value:6.28E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-5.27|P-value:7.54E-9 ID:SGTC_3153|Compound:9100258|FD-Score:-3.83|P-value:2.02E-5 ID:SGTC_3228|Compound:9131799|FD-Score:-3.06|P-value:5.19E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.12|P-value:4.16E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.09|P-value:4.65E-4

Top fitness defect scores for YDR317W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1308 1187-1617 9.31 41.4 µM 5.18E-24 fatty acid desaturase (OLE1) 4 6.55E-21
2 SGTC_788 1182-0090 7.96 188.0 µM 4.63E-18 endomembrane recycling 20 8.91E-16
3 SGTC_2398 5228213 6.85 48.8 µM 7.07E-14 iron homeostasis 5 3.63E-12
4 SGTC_486 niguldipine 6.38 82.0 µM 2.92E-12 amide catabolism 6 9.01E-11
5 SGTC_457 grayanotoxin iii 6.25 135.0 µM 7.65E-12 21 2.07E-10
6 SGTC_15 0266-0086 6.01 27.1 µM 4.50E-11 endomembrane recycling 20 9.54E-10
7 SGTC_2688 kanamycin b 5.66 96.7 µM 5.07E-10 calcium & mitochondrial duress 186 7.72E-9
8 SGTC_2021 4019055 5.39 173.0 µM 2.96E-9 endomembrane recycling 56 3.54E-8
9 SGTC_1230 0170-0365 5.31 3.8 µM 5.01E-9 endomembrane recycling 31 5.59E-8
10 SGTC_2322 7413319 5.21 38.2 µM 9.45E-9 ERAD & cell cycle 87 9.66E-8
11 SGTC_1800 st050079 5.05 29.1 µM 2.52E-8 NEO1-PIK1 72 2.26E-7
12 SGTC_1803 st050068 4.56 52.4 µM 4.13E-7 NEO1-PIK1 136 2.53E-6
13 SGTC_1754 st042065 4.50 16.1 µM 5.70E-7 NEO1-PIK1 151 3.34E-6
14 SGTC_114 0364-0001 4.39 490.3 µM 1.07E-6 34 5.74E-6
15 SGTC_649 1123-0311 4.36 367.0 µM 1.24E-6 endomembrane recycling 54 6.54E-6
16 SGTC_16 erodoxin 4.27 22.8 µM 1.93E-6 unfolded protein response 56 9.59E-6
17 SGTC_1818 st052136 4.11 56.3 µM 4.39E-6 NEO1-PIK1 43 1.95E-5
18 SGTC_1339 1486-1321 4.04 22.7 µM 6.23E-6 ERG2 19 2.64E-5
19 SGTC_515 4092-1064 4.02 102.0 µM 6.95E-6 plasma membrane duress 59 2.91E-5
20 SGTC_2006 4011487 3.79 200.0 µM 2.12E-5 endomembrane recycling 87 7.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.315 4.49E-78 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.288 7.29E-65 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.264 1.46E-54 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.247 7.63E-48 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.234 4.96E-43 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.226 3.71E-40 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.223 5.80E-39 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.222 8.32E-39 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.220 5.38E-38 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.216 1.17E-36 YEL048C TCA17 hom Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
0.214 3.97E-36 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.212 2.15E-35 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.210 1.26E-34 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.209 1.85E-34 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.207 8.26E-34 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress