YDR337W / MRPS28

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR337W / MRPS28

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.44|P-value:3.75E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.52|P-value:8.48E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.88|P-value:2.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.82|P-value:1.45E-12 ID:SGTC_116|Compound:0155-0182|FD-Score:3.56|P-value:7.52E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.65|P-value:5.69E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.15|P-value:1.06E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.34|P-value:5.29E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.69|P-value:4.96E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.07|P-value:1.43E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.14|P-value:2.24E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.34|P-value:5.03E-14 ID:SGTC_214|Compound:4373-3496|FD-Score:3.58|P-value:7.14E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.53|P-value:8.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.70|P-value:4.65E-30 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.40|P-value:7.18E-21 ID:SGTC_283|Compound:0987-0079|FD-Score:3.55|P-value:7.82E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.07|P-value:1.38E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.50|P-value:2.91E-21 ID:SGTC_311|Compound:1315-0136|FD-Score:3.53|P-value:8.25E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.51|P-value:8.45E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.53|P-value:8.12E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.43|P-value:6.27E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.53|P-value:8.15E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.54|P-value:7.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.75|P-value:8.10E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.72|P-value:4.44E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.57|P-value:7.23E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.02|P-value:1.61E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.78|P-value:1.23E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:3.71|P-value:4.69E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.57|P-value:7.05E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.63|P-value:5.99E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.85|P-value:2.99E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.63|P-value:1.80E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.64|P-value:1.74E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.67|P-value:5.10E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.62|P-value:6.00E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.45|P-value:3.58E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:9.27|P-value:6.65E-17 ID:SGTC_911|Compound:3456-4043|FD-Score:3.98|P-value:1.93E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.89|P-value:2.52E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.04|P-value:1.53E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.27|P-value:1.28E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.80|P-value:3.53E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.70|P-value:4.90E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.64|P-value:1.74E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.73|P-value:4.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.35|P-value:5.16E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.28|P-value:6.56E-5 ID:SGTC_1742|Compound:st038235|FD-Score:6.46|P-value:4.10E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.58|P-value:6.77E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.60|P-value:6.67E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.94|P-value:2.23E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.93|P-value:2.26E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-5.40|P-value:7.07E-7 ID:SGTC_1983|Compound:st071813|FD-Score:3.89|P-value:2.64E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.63|P-value:1.79E-5 ID:SGTC_1987|Compound:st072290|FD-Score:4.01|P-value:1.73E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.33|P-value:5.69E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.95|P-value:2.06E-4 ID:SGTC_2052|Compound:5265182|FD-Score:5.17|P-value:1.95E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.67|P-value:5.29E-4 ID:SGTC_2099|Compound:5377090|FD-Score:5.95|P-value:5.58E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.72|P-value:1.27E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.40|P-value:7.18E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-5.00|P-value:3.88E-6 ID:SGTC_2294|Compound:7971431|FD-Score:3.68|P-value:5.21E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.39|P-value:4.47E-5 ID:SGTC_2299|Compound:7976368|FD-Score:4.01|P-value:1.76E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-5.20|P-value:1.65E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.69|P-value:5.05E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.63|P-value:5.88E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.72|P-value:4.47E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:7.69|P-value:3.26E-12 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.57|P-value:7.09E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.38|P-value:4.47E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:4.13|P-value:1.16E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.15|P-value:1.93E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.63|P-value:6.10E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-5.79|P-value:1.16E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-3.82|P-value:3.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.48|P-value:4.88E-7 ID:SGTC_2932|Compound:9016711|FD-Score:3.72|P-value:4.58E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.80|P-value:3.45E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.23|P-value:1.32E-8 ID:SGTC_3296|Compound:9122258|FD-Score:-5.71|P-value:1.72E-7 ID:SGTC_10|Compound:0279-0212|FD-Score:4.44|P-value:3.75E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.52|P-value:8.48E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.88|P-value:2.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.82|P-value:1.45E-12 ID:SGTC_116|Compound:0155-0182|FD-Score:3.56|P-value:7.52E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.65|P-value:5.69E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.15|P-value:1.06E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.34|P-value:5.29E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.69|P-value:4.96E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.07|P-value:1.43E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.14|P-value:2.24E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.34|P-value:5.03E-14 ID:SGTC_214|Compound:4373-3496|FD-Score:3.58|P-value:7.14E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.53|P-value:8.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.70|P-value:4.65E-30 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.40|P-value:7.18E-21 ID:SGTC_283|Compound:0987-0079|FD-Score:3.55|P-value:7.82E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.07|P-value:1.38E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.50|P-value:2.91E-21 ID:SGTC_311|Compound:1315-0136|FD-Score:3.53|P-value:8.25E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.51|P-value:8.45E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.53|P-value:8.12E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.43|P-value:6.27E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.53|P-value:8.15E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.54|P-value:7.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.75|P-value:8.10E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.72|P-value:4.44E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.57|P-value:7.23E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.02|P-value:1.61E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.78|P-value:1.23E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:3.71|P-value:4.69E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.57|P-value:7.05E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.63|P-value:5.99E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.85|P-value:2.99E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.63|P-value:1.80E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.64|P-value:1.74E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.67|P-value:5.10E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.62|P-value:6.00E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.45|P-value:3.58E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:9.27|P-value:6.65E-17 ID:SGTC_911|Compound:3456-4043|FD-Score:3.98|P-value:1.93E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.89|P-value:2.52E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.04|P-value:1.53E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.27|P-value:1.28E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.80|P-value:3.53E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.70|P-value:4.90E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.64|P-value:1.74E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.73|P-value:4.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.35|P-value:5.16E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.28|P-value:6.56E-5 ID:SGTC_1742|Compound:st038235|FD-Score:6.46|P-value:4.10E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.58|P-value:6.77E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.60|P-value:6.67E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.94|P-value:2.23E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.93|P-value:2.26E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-5.40|P-value:7.07E-7 ID:SGTC_1983|Compound:st071813|FD-Score:3.89|P-value:2.64E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.63|P-value:1.79E-5 ID:SGTC_1987|Compound:st072290|FD-Score:4.01|P-value:1.73E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.33|P-value:5.69E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.95|P-value:2.06E-4 ID:SGTC_2052|Compound:5265182|FD-Score:5.17|P-value:1.95E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.67|P-value:5.29E-4 ID:SGTC_2099|Compound:5377090|FD-Score:5.95|P-value:5.58E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.72|P-value:1.27E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.40|P-value:7.18E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-5.00|P-value:3.88E-6 ID:SGTC_2294|Compound:7971431|FD-Score:3.68|P-value:5.21E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.39|P-value:4.47E-5 ID:SGTC_2299|Compound:7976368|FD-Score:4.01|P-value:1.76E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-5.20|P-value:1.65E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.69|P-value:5.05E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.63|P-value:5.88E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.72|P-value:4.47E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:7.69|P-value:3.26E-12 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.57|P-value:7.09E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.38|P-value:4.47E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:4.13|P-value:1.16E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.15|P-value:1.93E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.63|P-value:6.10E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-5.79|P-value:1.16E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-3.82|P-value:3.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.48|P-value:4.88E-7 ID:SGTC_2932|Compound:9016711|FD-Score:3.72|P-value:4.58E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.80|P-value:3.45E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.23|P-value:1.32E-8 ID:SGTC_3296|Compound:9122258|FD-Score:-5.71|P-value:1.72E-7

Top fitness defect scores for YDR337W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.70 5.3 µM 4.65E-30 135 3.26E-37
2 SGTC_310 1273-0058 10.50 1.1 µM 2.91E-21 mitochondrial stress 36 3.38E-26
3 SGTC_275 trichlorophene 10.40 5.7 µM 7.18E-21 mitochondrial stress 40 1.05E-25
4 SGTC_908 3448-7491 9.27 47.7 µM 6.65E-17 mitochondrial stress 11 9.63E-21
5 SGTC_173 1273-0061 8.34 2.7 µM 5.03E-14 mitochondrial stress 60 3.85E-17
6 SGTC_70 0141-0289 7.82 43.3 µM 1.45E-12 mitochondrial stress 42 2.57E-15
7 SGTC_2603 homopterocarpin 7.69 100.0 µM 3.26E-12 2 7.08E-15
8 SGTC_1742 st038235 6.46 28.9 µM 4.10E-9 mitochondrial stress 37 5.26E-11
9 SGTC_3152 9099253 6.23 49.5 µM 1.32E-8 NEO1-PIK1 53 2.26E-10
10 SGTC_2099 5377090 5.95 177.4 µM 5.58E-8 3 1.36E-9
11 SGTC_581 0958-0271 5.78 211.0 µM 1.23E-7 18 3.67E-9
12 SGTC_386 1509-0011 5.43 3.1 µM 6.27E-7 99 2.79E-8
13 SGTC_2250 alverine citrate 5.40 130.0 µM 7.18E-7 78 3.30E-8
14 SGTC_1188 1403-0014 5.27 4.6 µM 1.28E-6 mitochondrial stress 23 6.76E-8
15 SGTC_2052 5265182 5.17 7.1 µM 1.95E-6 8 1.15E-7
16 SGTC_168 3970-0862 5.14 530.5 µM 2.24E-6 67 1.36E-7
17 SGTC_2232 chlorophetanol 4.72 41.5 µM 1.27E-5 TRP & mitochondrial translation 89 1.18E-6
18 SGTC_1576 erythromycin ethylsuccinate 4.64 23.2 µM 1.74E-5 13 1.74E-6
19 SGTC_820 1582-0060 4.64 59.9 µM 1.74E-5 17 1.74E-6
20 SGTC_1984 st072354 4.63 53.1 µM 1.79E-5 4 1.81E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.524 2.70E-236 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.523 8.19E-235 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.506 1.03E-217 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.490 5.05E-202 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.486 3.43E-198 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.471 1.36E-184 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.468 2.60E-182 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.468 1.57E-181 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.458 1.99E-173 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.457 9.20E-173 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.456 1.00E-171 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.453 2.09E-169 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.444 6.54E-162 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.441 3.26E-159 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.434 3.23E-153 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs