YDR345C / HXT3

Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR345C / HXT3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.52|P-value:4.72E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.58|P-value:3.95E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.09|P-value:3.76E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:5.42|P-value:1.55E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:4.93|P-value:1.71E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:4.74|P-value:4.01E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.02|P-value:7.77E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:4.01|P-value:8.10E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.47|P-value:5.60E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.72|P-value:2.40E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.18|P-value:2.70E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.72|P-value:1.56E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.48|P-value:1.25E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.43|P-value:6.57E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.44|P-value:6.24E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.05|P-value:6.94E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.65|P-value:5.96E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.98|P-value:9.11E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.32|P-value:6.28E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.36|P-value:8.26E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-3.19|P-value:9.86E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.34|P-value:5.89E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.67|P-value:2.87E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.25|P-value:3.21E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.53|P-value:4.59E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.29|P-value:7.15E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.39|P-value:1.12E-5 ID:SGTC_2290|Compound:7904846|FD-Score:4.25|P-value:3.13E-5 ID:SGTC_2302|Compound:7771753|FD-Score:4.50|P-value:1.13E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.57|P-value:3.96E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.62|P-value:6.82E-6 ID:SGTC_2344|Compound:7990960|FD-Score:-3.36|P-value:5.54E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.37|P-value:1.22E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.84|P-value:1.01E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:9.14|P-value:2.22E-18 ID:SGTC_2619|Compound:obliquin|FD-Score:6.11|P-value:3.80E-9 ID:SGTC_2701|Compound:st077767|FD-Score:3.65|P-value:3.01E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.33|P-value:2.46E-7 ID:SGTC_2914|Compound:7968218|FD-Score:-3.50|P-value:3.48E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.20|P-value:3.95E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.52|P-value:3.18E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.48|P-value:5.40E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.31|P-value:2.46E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.48|P-value:5.51E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.38|P-value:7.73E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.21|P-value:9.02E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.52|P-value:4.72E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.58|P-value:3.95E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.09|P-value:3.76E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:5.42|P-value:1.55E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:4.93|P-value:1.71E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:4.74|P-value:4.01E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.02|P-value:7.77E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:4.01|P-value:8.10E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.47|P-value:5.60E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.72|P-value:2.40E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.18|P-value:2.70E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.72|P-value:1.56E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.48|P-value:1.25E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.43|P-value:6.57E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.44|P-value:6.24E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.05|P-value:6.94E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.65|P-value:5.96E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.98|P-value:9.11E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:-3.32|P-value:6.28E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.36|P-value:8.26E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-3.19|P-value:9.86E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.34|P-value:5.89E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.67|P-value:2.87E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.25|P-value:3.21E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.53|P-value:4.59E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.29|P-value:7.15E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.39|P-value:1.12E-5 ID:SGTC_2290|Compound:7904846|FD-Score:4.25|P-value:3.13E-5 ID:SGTC_2302|Compound:7771753|FD-Score:4.50|P-value:1.13E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.57|P-value:3.96E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.62|P-value:6.82E-6 ID:SGTC_2344|Compound:7990960|FD-Score:-3.36|P-value:5.54E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.37|P-value:1.22E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.84|P-value:1.01E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:9.14|P-value:2.22E-18 ID:SGTC_2619|Compound:obliquin|FD-Score:6.11|P-value:3.80E-9 ID:SGTC_2701|Compound:st077767|FD-Score:3.65|P-value:3.01E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.33|P-value:2.46E-7 ID:SGTC_2914|Compound:7968218|FD-Score:-3.50|P-value:3.48E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.20|P-value:3.95E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.52|P-value:3.18E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.48|P-value:5.40E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.31|P-value:2.46E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.48|P-value:5.51E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.38|P-value:7.73E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.21|P-value:9.02E-4

Top fitness defect scores for YDR345C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 9.14 48.7 µM 2.22E-18 cell wall 20 3.06E-20
2 SGTC_2619 obliquin 6.11 87.9 µM 3.80E-9 cell wall 71 4.89E-10
3 SGTC_72 0744-0168 5.42 198.4 µM 1.55E-7 RPP1 & pyrimidine depletion 9 2.96E-8
4 SGTC_2833 9001315 5.33 45.5 µM 2.46E-7 amide catabolism 26 4.94E-8
5 SGTC_91 0417-1751 4.93 58.4 µM 1.71E-6 Golgi 25 4.21E-7
6 SGTC_161 4065-0411 4.74 162.2 µM 4.01E-6 46 1.08E-6
7 SGTC_1367 1812-0510 4.65 76.9 µM 5.96E-6 8 1.68E-6
8 SGTC_2340 7987427 4.62 183.4 µM 6.82E-6 19 1.95E-6
9 SGTC_2302 7771753 4.50 200.0 µM 1.13E-5 28 3.41E-6
10 SGTC_1055 3448-0672 4.48 86.0 µM 1.25E-5 19 3.80E-6
11 SGTC_2137 5261020 4.40 140.0 µM 1.70E-5 31 5.34E-6
12 SGTC_3054 9094397 4.31 49.5 µM 2.46E-5 fatty acid desaturase (OLE1) 22 8.07E-6
13 SGTC_2290 7904846 4.25 200.0 µM 3.13E-5 15 1.05E-5
14 SGTC_2098 5376439 4.25 882.5 nM 3.21E-5 10 1.08E-5
15 SGTC_2924 9010168 4.20 62.8 µM 3.95E-5 cell wall signaling 30 1.36E-5
16 SGTC_1230 0170-0365 4.05 3.8 µM 6.94E-5 endomembrane recycling 61 2.54E-5
17 SGTC_514 4466-0038 4.02 2.6 nM 7.77E-5 cell wall 149 2.89E-5
18 SGTC_759 3486-0358 4.01 89.3 µM 8.10E-5 18 3.02E-5
19 SGTC_1469 k284-2957 3.98 126.0 µM 9.11E-5 9 3.44E-5
20 SGTC_31 0508-1974 3.89 57.2 µM 1.29E-4 27 5.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.74E-42 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.192 4.13E-29 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.177 5.03E-25 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.173 6.27E-24 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.161 6.22E-21 YML048W GSF2 hom ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.155 2.03E-19 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.148 7.53E-18 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.142 1.26E-16 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.137 1.38E-15 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.137 1.67E-15 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130 4.18E-14 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.126 1.96E-13 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.124 4.88E-13 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.123 7.91E-13 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.121 1.76E-12 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress