HIPHOP chemogenomics database

YDR345C / HXT3

Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR345C / HXT3

Click on Significant Values for Screen Details

Top fitness defect scores for YDR345C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2584	androsterone	9.14	48.7 µM	2.22E-18	cell wall	20	3.06E-20
2	SGTC_2619	obliquin	6.11	87.9 µM	3.80E-9	cell wall	71	4.89E-10
3	SGTC_72	0744-0168	5.42	198.4 µM	1.55E-7	RPP1 & pyrimidine depletion	9	2.96E-8
4	SGTC_2833	9001315	5.33	45.5 µM	2.46E-7	amide catabolism	26	4.94E-8
5	SGTC_91	0417-1751	4.93	58.4 µM	1.71E-6	Golgi	25	4.21E-7
6	SGTC_161	4065-0411	4.74	162.2 µM	4.01E-6		46	1.08E-6
7	SGTC_1367	1812-0510	4.65	76.9 µM	5.96E-6		8	1.68E-6
8	SGTC_2340	7987427	4.62	183.4 µM	6.82E-6		19	1.95E-6
9	SGTC_2302	7771753	4.50	200.0 µM	1.13E-5		28	3.41E-6
10	SGTC_1055	3448-0672	4.48	86.0 µM	1.25E-5		19	3.80E-6
11	SGTC_2137	5261020	4.40	140.0 µM	1.70E-5		31	5.34E-6
12	SGTC_3054	9094397	4.31	49.5 µM	2.46E-5	fatty acid desaturase (OLE1)	22	8.07E-6
13	SGTC_2290	7904846	4.25	200.0 µM	3.13E-5		15	1.05E-5
14	SGTC_2098	5376439	4.25	882.5 nM	3.21E-5		10	1.08E-5
15	SGTC_2924	9010168	4.20	62.8 µM	3.95E-5	cell wall signaling	30	1.36E-5
16	SGTC_1230	0170-0365	4.05	3.8 µM	6.94E-5	endomembrane recycling	61	2.54E-5
17	SGTC_514	4466-0038	4.02	2.6 nM	7.77E-5	cell wall	149	2.89E-5
18	SGTC_759	3486-0358	4.01	89.3 µM	8.10E-5		18	3.02E-5
19	SGTC_1469	k284-2957	3.98	126.0 µM	9.11E-5		9	3.44E-5
20	SGTC_31	0508-1974	3.89	57.2 µM	1.29E-4		27	5.05E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.232	2.74E-42	YBL085W	BOI1	hom	Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.192	4.13E-29	YJL159W	HSP150	hom	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.177	5.03E-25	YLR102C	APC9	hom	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.173	6.27E-24	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.161	6.22E-21	YML048W	GSF2	hom	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.155	2.03E-19	YGL033W	HOP2	hom	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.148	7.53E-18	YGL042C_d	YGL042C_d	hom	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.142	1.26E-16	YKL036C_d	YKL036C_d	het	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.137	1.38E-15	YNL229C	URE2	hom	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.137	1.67E-15	YBR134W_d	YBR134W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130	4.18E-14	YKL035W	UGP1	het	UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.126	1.96E-13	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.124	4.88E-13	YBR023C	CHS3	hom	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.123	7.91E-13	YML119W_p	YML119W_p	hom	Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.121	1.76E-12	YLR212C	TUB4	het	Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress