YDR362C / TFC6

One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR362C / TFC6

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:3.35|P-value:4.91E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.22|P-value:7.55E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.00|P-value:4.35E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.40|P-value:4.07E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.59|P-value:3.51E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.35|P-value:7.07E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.37|P-value:6.70E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.28|P-value:6.36E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.69|P-value:1.44E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.25|P-value:7.02E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.72|P-value:1.30E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.46|P-value:3.38E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.79|P-value:1.35E-6 ID:SGTC_633|Compound:0437-0093|FD-Score:5.07|P-value:3.52E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:3.38|P-value:4.46E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.27|P-value:1.43E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:7.64|P-value:4.85E-14 ID:SGTC_858|Compound:0438-0351|FD-Score:3.56|P-value:2.33E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:9.41|P-value:2.60E-20 ID:SGTC_874|Compound:0599-0792|FD-Score:4.40|P-value:7.96E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.26|P-value:9.68E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.74|P-value:1.78E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.15|P-value:9.54E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.01|P-value:4.15E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.54|P-value:2.50E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.80|P-value:9.65E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.25|P-value:1.52E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.72|P-value:1.93E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.19|P-value:8.45E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.52|P-value:3.41E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.42|P-value:3.80E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.80|P-value:9.66E-5 ID:SGTC_1773|Compound:st048542|FD-Score:3.89|P-value:6.86E-5 ID:SGTC_1776|Compound:st049249|FD-Score:4.04|P-value:3.76E-5 ID:SGTC_1794|Compound:st048918|FD-Score:4.48|P-value:5.70E-6 ID:SGTC_1892|Compound:st058411|FD-Score:3.61|P-value:1.93E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.36|P-value:4.79E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.95|P-value:6.54E-7 ID:SGTC_1962|Compound:st076595|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_1966|Compound:st070145|FD-Score:7.81|P-value:1.32E-14 ID:SGTC_1984|Compound:st072354|FD-Score:3.67|P-value:1.57E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.59|P-value:3.43E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.28|P-value:6.18E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.15|P-value:2.38E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.48|P-value:5.63E-6 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.75|P-value:1.77E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:8.09|P-value:1.66E-15 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.18|P-value:2.03E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.58|P-value:2.17E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.18|P-value:2.08E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.25|P-value:7.00E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.94|P-value:8.53E-5 ID:SGTC_2785|Compound:7756463|FD-Score:5.94|P-value:3.38E-9 ID:SGTC_2789|Compound:5281112|FD-Score:3.81|P-value:9.17E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.54|P-value:2.53E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.58|P-value:2.21E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.48|P-value:5.77E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.66|P-value:1.64E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.66|P-value:1.60E-8 ID:SGTC_3062|Compound:9077494|FD-Score:3.56|P-value:2.36E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.59|P-value:2.14E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.30|P-value:5.79E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-4.52|P-value:7.76E-6 ID:SGTC_3283|Compound:9109332|FD-Score:5.19|P-value:1.96E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.35|P-value:4.91E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.22|P-value:7.55E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.00|P-value:4.35E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.40|P-value:4.07E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.59|P-value:3.51E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.35|P-value:7.07E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.37|P-value:6.70E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.28|P-value:6.36E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.69|P-value:1.44E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.25|P-value:7.02E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.72|P-value:1.30E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.46|P-value:3.38E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.79|P-value:1.35E-6 ID:SGTC_633|Compound:0437-0093|FD-Score:5.07|P-value:3.52E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:3.38|P-value:4.46E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.27|P-value:1.43E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:7.64|P-value:4.85E-14 ID:SGTC_858|Compound:0438-0351|FD-Score:3.56|P-value:2.33E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:9.41|P-value:2.60E-20 ID:SGTC_874|Compound:0599-0792|FD-Score:4.40|P-value:7.96E-6 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.26|P-value:9.68E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.74|P-value:1.78E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.15|P-value:9.54E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.01|P-value:4.15E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.54|P-value:2.50E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.80|P-value:9.65E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.25|P-value:1.52E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.72|P-value:1.93E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.19|P-value:8.45E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.52|P-value:3.41E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.42|P-value:3.80E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.80|P-value:9.66E-5 ID:SGTC_1773|Compound:st048542|FD-Score:3.89|P-value:6.86E-5 ID:SGTC_1776|Compound:st049249|FD-Score:4.04|P-value:3.76E-5 ID:SGTC_1794|Compound:st048918|FD-Score:4.48|P-value:5.70E-6 ID:SGTC_1892|Compound:st058411|FD-Score:3.61|P-value:1.93E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.36|P-value:4.79E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.95|P-value:6.54E-7 ID:SGTC_1962|Compound:st076595|FD-Score:3.52|P-value:2.72E-4 ID:SGTC_1966|Compound:st070145|FD-Score:7.81|P-value:1.32E-14 ID:SGTC_1984|Compound:st072354|FD-Score:3.67|P-value:1.57E-4 ID:SGTC_1985|Compound:st071382|FD-Score:4.59|P-value:3.43E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.28|P-value:6.18E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.15|P-value:2.38E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.48|P-value:5.63E-6 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.75|P-value:1.77E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:8.09|P-value:1.66E-15 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.18|P-value:2.03E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.58|P-value:2.17E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.18|P-value:2.08E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.25|P-value:7.00E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.94|P-value:8.53E-5 ID:SGTC_2785|Compound:7756463|FD-Score:5.94|P-value:3.38E-9 ID:SGTC_2789|Compound:5281112|FD-Score:3.81|P-value:9.17E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.54|P-value:2.53E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.58|P-value:2.21E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.48|P-value:5.77E-6 ID:SGTC_3004|Compound:9076122|FD-Score:3.66|P-value:1.64E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.66|P-value:1.60E-8 ID:SGTC_3062|Compound:9077494|FD-Score:3.56|P-value:2.36E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.59|P-value:2.14E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.30|P-value:5.79E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-4.52|P-value:7.76E-6 ID:SGTC_3283|Compound:9109332|FD-Score:5.19|P-value:1.96E-7

Top fitness defect scores for YDR362C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_867 0518-0118 9.41 155.0 µM 2.60E-20 DNA intercalators 1 2.47E-21 1.78
2 SGTC_2638 epoxomicin 8.09 18.0 µM 1.66E-15 1 3.08E-16 3.20
3 SGTC_1966 st070145 7.81 16.1 µM 1.32E-14 1 2.78E-15 2.33
4 SGTC_852 0418-0143 7.64 439.0 µM 4.85E-14 calcium & mitochondrial duress 2 1.10E-14 1.47
5 SGTC_2785 7756463 5.94 72.7 µM 3.38E-9 3 1.47E-9 0.47
6 SGTC_3040 9091894 5.66 49.5 µM 1.60E-8 DNA intercalators 3 7.55E-9 0.06
7 SGTC_1459 k035-0031 5.52 35.7 µM 3.41E-8 DNA intercalators 3 1.68E-8 0.43
8 SGTC_3283 9109332 5.19 35.8 µM 1.96E-7 DNA intercalators 1 1.07E-7 0.64
9 SGTC_2639 lactacystin 5.18 53.0 µM 2.03E-7 4 1.11E-7 0.65
10 SGTC_2666 tannic acid 5.18 100.0 µM 2.08E-7 iron homeostasis 7 1.14E-7 0.22
11 SGTC_633 0437-0093 5.07 97.7 µM 3.52E-7 DNA intercalators 4 1.98E-7 0.76
12 SGTC_1926 methyl fluorone black 4.95 53.6 µM 6.54E-7 DNA intercalators 18 3.80E-7 0.01
13 SGTC_632 0781-2353 4.79 4.7 µM 1.35E-6 Golgi 10 8.17E-7 5.04E-4
14 SGTC_1415 3966-0071 4.72 78.1 µM 1.93E-6 DNA intercalators 4 1.19E-6 0.46
15 SGTC_1985 st071382 4.59 65.5 µM 3.43E-6 1 2.18E-6 0.47
16 SGTC_412 gemfibrozil 4.59 100.0 µM 3.51E-6 DNA intercalators 3 2.23E-6 0.35
17 SGTC_2128 5255449 4.48 168.5 µM 5.63E-6 3 3.67E-6 0.38
18 SGTC_1794 st048918 4.48 76.9 µM 5.70E-6 1 3.72E-6 0.78
19 SGTC_2958 9077254 4.48 16.7 µM 5.77E-6 3 3.77E-6 0.24
20 SGTC_874 0599-0792 4.40 117.0 µM 7.96E-6 2 5.29E-6 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 1.01E-74 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.286 4.66E-64 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.275 3.08E-59 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.252 9.07E-50 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.225 1.52E-39 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.213 1.44E-35 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.204 6.27E-33 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.204 7.38E-33 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.196 3.79E-30 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.192 4.44E-29 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.177 7.24E-25 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.164 1.23E-21 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.151 1.24E-18 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.143 9.36E-17 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 3.90E-16 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque