YDR371W_p / CTS2

Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR371W / CTS2

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.11|P-value:4.63E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.27|P-value:2.50E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.57|P-value:7.40E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:5.71|P-value:6.24E-10 ID:SGTC_615|Compound:k087-0205|FD-Score:3.07|P-value:5.40E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.98|P-value:7.68E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:7.07|P-value:2.59E-14 ID:SGTC_775|Compound:4577-0580|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.47|P-value:1.11E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.09|P-value:5.04E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.33|P-value:1.98E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.34|P-value:1.86E-4 ID:SGTC_1706|Compound:st031321|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.10|P-value:4.79E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.40|P-value:1.49E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.09|P-value:5.11E-4 ID:SGTC_2347|Compound:9049783|FD-Score:19.30|P-value:1.63E-94 ID:SGTC_2348|Compound:9022543|FD-Score:-5.79|P-value:3.69E-10 ID:SGTC_2349|Compound:9023730|FD-Score:3.45|P-value:1.22E-4 ID:SGTC_2350|Compound:9023895|FD-Score:6.01|P-value:8.06E-11 ID:SGTC_2396|Compound:5342950|FD-Score:-3.53|P-value:8.75E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.45|P-value:1.21E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-5.06|P-value:3.60E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.18|P-value:4.38E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.12|P-value:4.50E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.05|P-value:5.81E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.11|P-value:4.62E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.29|P-value:2.27E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.62|P-value:5.95E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.36|P-value:1.74E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.11|P-value:4.63E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.27|P-value:2.50E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.57|P-value:7.40E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:5.71|P-value:6.24E-10 ID:SGTC_615|Compound:k087-0205|FD-Score:3.07|P-value:5.40E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.98|P-value:7.68E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:7.07|P-value:2.59E-14 ID:SGTC_775|Compound:4577-0580|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.47|P-value:1.11E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.09|P-value:5.04E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.33|P-value:1.98E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.34|P-value:1.86E-4 ID:SGTC_1706|Compound:st031321|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.10|P-value:4.79E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.40|P-value:1.49E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.09|P-value:5.11E-4 ID:SGTC_2347|Compound:9049783|FD-Score:19.30|P-value:1.63E-94 ID:SGTC_2348|Compound:9022543|FD-Score:-5.79|P-value:3.69E-10 ID:SGTC_2349|Compound:9023730|FD-Score:3.45|P-value:1.22E-4 ID:SGTC_2350|Compound:9023895|FD-Score:6.01|P-value:8.06E-11 ID:SGTC_2396|Compound:5342950|FD-Score:-3.53|P-value:8.75E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.45|P-value:1.21E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-5.06|P-value:3.60E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.18|P-value:4.38E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.79|P-value:2.81E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.12|P-value:4.50E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.05|P-value:5.81E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.11|P-value:4.62E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.29|P-value:2.27E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.62|P-value:5.95E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.36|P-value:1.74E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.93|P-value:9.15E-4

Top fitness defect scores for YDR371W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2347 9049783 19.30 174.8 µM 1.63E-94 1 1.04E-83
2 SGTC_773 4358-1457 7.07 44.6 µM 2.59E-14 10 7.59E-13
3 SGTC_2350 9023895 6.01 38.9 µM 8.06E-11 ergosterol biosynthesis 11 9.36E-10
4 SGTC_225 nsc-122657 5.71 1.0 µM 6.24E-10 5 5.74E-9
5 SGTC_2541 muurolladie-3-one 4.18 83.1 µM 4.38E-6 excess fatty acid 22 1.47E-5
6 SGTC_2546 rhodinyl acetate 3.79 100.0 µM 2.81E-5 14 7.68E-5
7 SGTC_224 benfluorex 3.57 43.9 µM 7.40E-5 9 1.82E-4
8 SGTC_775 4577-0580 3.45 57.3 µM 1.21E-4 14 2.82E-4
9 SGTC_2349 9023730 3.45 187.1 µM 1.22E-4 53 2.83E-4
10 SGTC_2333 9017922 3.40 200.0 µM 1.49E-4 44 3.38E-4
11 SGTC_1706 st031321 3.38 10.0 µM 1.63E-4 TSC3-RPN4 22 3.67E-4
12 SGTC_3304 9125678 3.36 46.1 µM 1.74E-4 81 3.88E-4
13 SGTC_1315 1237-0019 3.34 3.7 µM 1.86E-4 21 4.12E-4
14 SGTC_1252 0493-0875 3.33 34.8 µM 1.98E-4 51 4.37E-4
15 SGTC_223 busulfan 3.27 5.0 mM 2.50E-4 16 5.37E-4
16 SGTC_1790 st045711 3.12 43.5 µM 4.43E-4 36 8.92E-4
17 SGTC_1993 st073995 3.10 70.8 µM 4.79E-4 46 9.57E-4
18 SGTC_615 k087-0205 3.07 167.0 µM 5.40E-4 43 0.00106
19 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.05 70.0 µM 5.81E-4 redox potentiating 130 0.00114
20 SGTC_737 1950-0117 2.98 57.9 µM 7.68E-4 62 0.00146

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 1.54E-68 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.245 9.84E-47 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.245 7.65E-47 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.227 3.05E-40 YMR125W STO1 hom Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
0.180 8.42E-26 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.180 1.33E-25 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.177 5.77E-25 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
0.169 8.26E-23 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.164 1.59E-21 YPR115W RGC1 hom Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.142 1.68E-16 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.137 1.50E-15 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.132 1.96E-14 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.131 3.11E-14 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.127 2.13E-13 YCR027C RHB1 hom Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
0.123 8.49E-13 YPL162C_p YPL162C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology