YDR372C / VPS74

Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR372C / VPS74

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:9.94|P-value:4.49E-20 ID:SGTC_43|Compound:0570-0105|FD-Score:5.65|P-value:1.31E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.92|P-value:2.11E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.81|P-value:6.15E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.89|P-value:2.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.06|P-value:5.74E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:4.97|P-value:3.10E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:22.00|P-value:5.51E-91 ID:SGTC_197|Compound:4544-0043|FD-Score:6.67|P-value:5.90E-10 ID:SGTC_206|Compound:4546-0025|FD-Score:18.10|P-value:2.45E-62 ID:SGTC_207|Compound:4185-0010|FD-Score:4.53|P-value:1.99E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:7.27|P-value:1.55E-11 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.07|P-value:6.77E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.30|P-value:2.60E-25 ID:SGTC_232|Compound:clozapine|FD-Score:8.60|P-value:1.82E-15 ID:SGTC_245|Compound:methotrexate|FD-Score:3.44|P-value:9.32E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:11.50|P-value:3.38E-26 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.23|P-value:8.68E-12 ID:SGTC_313|Compound:3474-0040|FD-Score:5.19|P-value:1.18E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:4.54|P-value:1.86E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.05|P-value:1.23E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.11|P-value:1.65E-6 ID:SGTC_459|Compound:nigericin|FD-Score:7.50|P-value:3.69E-12 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.04|P-value:1.24E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.88|P-value:1.37E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-5.15|P-value:7.57E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:4.76|P-value:7.72E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.54|P-value:2.29E-7 ID:SGTC_570|Compound:0987-0065|FD-Score:3.44|P-value:9.44E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.87|P-value:2.29E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:10.20|P-value:6.04E-21 ID:SGTC_649|Compound:1123-0311|FD-Score:7.03|P-value:7.11E-11 ID:SGTC_658|Compound:3253-0951|FD-Score:4.10|P-value:1.02E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.09|P-value:1.43E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:3.44|P-value:9.40E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.04|P-value:1.27E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.48|P-value:2.40E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.78|P-value:3.17E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.79|P-value:3.04E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.21|P-value:6.83E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.89|P-value:2.17E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:14.00|P-value:5.06E-38 ID:SGTC_962|Compound:1254-0300|FD-Score:3.97|P-value:1.59E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.48|P-value:8.39E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.46|P-value:5.82E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.02|P-value:2.03E-8 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.71|P-value:4.54E-10 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.68|P-value:4.43E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.66|P-value:4.69E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.32|P-value:9.01E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:7.36|P-value:9.18E-12 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.57|P-value:1.94E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.80|P-value:1.82E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.65|P-value:4.79E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.18|P-value:7.48E-5 ID:SGTC_1760|Compound:st045453|FD-Score:8.71|P-value:8.57E-16 ID:SGTC_1781|Compound:st038725|FD-Score:7.47|P-value:4.64E-12 ID:SGTC_1797|Compound:st048695|FD-Score:9.21|P-value:1.75E-17 ID:SGTC_1800|Compound:st050079|FD-Score:5.71|P-value:1.00E-7 ID:SGTC_1801|Compound:st050089|FD-Score:4.56|P-value:1.77E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.10|P-value:1.32E-8 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.52|P-value:7.28E-4 ID:SGTC_1991|Compound:st073000|FD-Score:9.52|P-value:1.53E-18 ID:SGTC_1993|Compound:st073995|FD-Score:4.07|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.55|P-value:1.80E-5 ID:SGTC_2036|Compound:5160441|FD-Score:7.30|P-value:1.29E-11 ID:SGTC_2058|Compound:5236698|FD-Score:3.52|P-value:7.30E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.45|P-value:9.13E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.95|P-value:1.71E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.88|P-value:4.55E-6 ID:SGTC_2440|Compound:5628896|FD-Score:7.50|P-value:3.76E-12 ID:SGTC_2485|Compound:5633444|FD-Score:4.51|P-value:2.08E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.70|P-value:1.03E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.34|P-value:8.47E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:18.30|P-value:2.35E-63 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.58|P-value:1.00E-9 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.57|P-value:1.69E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:10.70|P-value:4.82E-23 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.45|P-value:9.08E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.45|P-value:2.67E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.84|P-value:2.57E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.59|P-value:5.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.31|P-value:4.65E-5 ID:SGTC_2937|Compound:9044753|FD-Score:5.70|P-value:1.05E-7 ID:SGTC_3037|Compound:9091026|FD-Score:4.95|P-value:3.37E-6 ID:SGTC_3145|Compound:9085516|FD-Score:3.59|P-value:5.78E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.35|P-value:3.90E-5 ID:SGTC_3152|Compound:9099253|FD-Score:12.50|P-value:1.82E-30 ID:SGTC_3188|Compound:9110789|FD-Score:4.38|P-value:3.55E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:9.94|P-value:4.49E-20 ID:SGTC_43|Compound:0570-0105|FD-Score:5.65|P-value:1.31E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.92|P-value:2.11E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.81|P-value:6.15E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.89|P-value:2.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.06|P-value:5.74E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:4.97|P-value:3.10E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:22.00|P-value:5.51E-91 ID:SGTC_197|Compound:4544-0043|FD-Score:6.67|P-value:5.90E-10 ID:SGTC_206|Compound:4546-0025|FD-Score:18.10|P-value:2.45E-62 ID:SGTC_207|Compound:4185-0010|FD-Score:4.53|P-value:1.99E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:7.27|P-value:1.55E-11 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.07|P-value:6.77E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.30|P-value:2.60E-25 ID:SGTC_232|Compound:clozapine|FD-Score:8.60|P-value:1.82E-15 ID:SGTC_245|Compound:methotrexate|FD-Score:3.44|P-value:9.32E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:11.50|P-value:3.38E-26 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.23|P-value:8.68E-12 ID:SGTC_313|Compound:3474-0040|FD-Score:5.19|P-value:1.18E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:4.54|P-value:1.86E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.05|P-value:1.23E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.11|P-value:1.65E-6 ID:SGTC_459|Compound:nigericin|FD-Score:7.50|P-value:3.69E-12 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.04|P-value:1.24E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.88|P-value:1.37E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-5.15|P-value:7.57E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:4.76|P-value:7.72E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.54|P-value:2.29E-7 ID:SGTC_570|Compound:0987-0065|FD-Score:3.44|P-value:9.44E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.87|P-value:2.29E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:10.20|P-value:6.04E-21 ID:SGTC_649|Compound:1123-0311|FD-Score:7.03|P-value:7.11E-11 ID:SGTC_658|Compound:3253-0951|FD-Score:4.10|P-value:1.02E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.09|P-value:1.43E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:3.44|P-value:9.40E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.04|P-value:1.27E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.48|P-value:2.40E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.78|P-value:3.17E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.79|P-value:3.04E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.21|P-value:6.83E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.89|P-value:2.17E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:14.00|P-value:5.06E-38 ID:SGTC_962|Compound:1254-0300|FD-Score:3.97|P-value:1.59E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.48|P-value:8.39E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.46|P-value:5.82E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.02|P-value:2.03E-8 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.71|P-value:4.54E-10 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.68|P-value:4.43E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.66|P-value:4.69E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.32|P-value:9.01E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:7.36|P-value:9.18E-12 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.57|P-value:1.94E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.80|P-value:1.82E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.65|P-value:4.79E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.18|P-value:7.48E-5 ID:SGTC_1760|Compound:st045453|FD-Score:8.71|P-value:8.57E-16 ID:SGTC_1781|Compound:st038725|FD-Score:7.47|P-value:4.64E-12 ID:SGTC_1797|Compound:st048695|FD-Score:9.21|P-value:1.75E-17 ID:SGTC_1800|Compound:st050079|FD-Score:5.71|P-value:1.00E-7 ID:SGTC_1801|Compound:st050089|FD-Score:4.56|P-value:1.77E-5 ID:SGTC_1803|Compound:st050068|FD-Score:6.10|P-value:1.32E-8 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.52|P-value:7.28E-4 ID:SGTC_1991|Compound:st073000|FD-Score:9.52|P-value:1.53E-18 ID:SGTC_1993|Compound:st073995|FD-Score:4.07|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.55|P-value:1.80E-5 ID:SGTC_2036|Compound:5160441|FD-Score:7.30|P-value:1.29E-11 ID:SGTC_2058|Compound:5236698|FD-Score:3.52|P-value:7.30E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.45|P-value:9.13E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.95|P-value:1.71E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.88|P-value:4.55E-6 ID:SGTC_2440|Compound:5628896|FD-Score:7.50|P-value:3.76E-12 ID:SGTC_2485|Compound:5633444|FD-Score:4.51|P-value:2.08E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.70|P-value:1.03E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.34|P-value:8.47E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:18.30|P-value:2.35E-63 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.58|P-value:1.00E-9 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.57|P-value:1.69E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:10.70|P-value:4.82E-23 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.45|P-value:9.08E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.45|P-value:2.67E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.84|P-value:2.57E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.59|P-value:5.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.31|P-value:4.65E-5 ID:SGTC_2937|Compound:9044753|FD-Score:5.70|P-value:1.05E-7 ID:SGTC_3037|Compound:9091026|FD-Score:4.95|P-value:3.37E-6 ID:SGTC_3145|Compound:9085516|FD-Score:3.59|P-value:5.78E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.35|P-value:3.90E-5 ID:SGTC_3152|Compound:9099253|FD-Score:12.50|P-value:1.82E-30 ID:SGTC_3188|Compound:9110789|FD-Score:4.38|P-value:3.55E-5

Top fitness defect scores for YDR372C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_146 3448-8650 22.00 53.1 µM 5.51E-91 NEO1-PIK1 3 2.25E-107
2 SGTC_2658 polymyxin b sulfate 18.30 77.0 µM 2.35E-63 NEO1 3 9.49E-75
3 SGTC_206 4546-0025 18.10 72.0 µM 2.45E-62 NEO1 4 1.51E-73
4 SGTC_940 3232-1287 14.00 54.8 µM 5.06E-38 NEO1 2 8.07E-45
5 SGTC_3152 9099253 12.50 49.5 µM 1.82E-30 NEO1-PIK1 13 6.93E-36
6 SGTC_301 4119-0100 11.50 24.5 µM 3.38E-26 NEO1 13 7.73E-31
7 SGTC_221 trifluoperazine 11.30 10.3 µM 2.60E-25 NEO1-PIK1 45 8.62E-30
8 SGTC_2697 mebhydrolin 10.70 72.4 µM 4.82E-23 NEO1 15 4.15E-27
9 SGTC_637 1181-0519 10.20 7.3 µM 6.04E-21 fatty acid desaturase (OLE1) 20 1.26E-24
10 SGTC_15 0266-0086 9.94 27.1 µM 4.49E-20 endomembrane recycling 6 1.35E-23
11 SGTC_1991 st073000 9.52 8.9 µM 1.53E-18 NEO1 11 8.80E-22
12 SGTC_1797 st048695 9.21 56.8 µM 1.75E-17 NEO1 19 1.58E-20
13 SGTC_1760 st045453 8.71 10.4 µM 8.57E-16 NEO1-PIK1 43 1.58E-18
14 SGTC_232 clozapine 8.60 119.0 µM 1.82E-15 NEO1 18 3.84E-18
15 SGTC_459 nigericin 7.50 15.3 µM 3.69E-12 14 3.17E-14
16 SGTC_2440 5628896 7.50 157.8 µM 3.76E-12 5 3.23E-14
17 SGTC_1781 st038725 7.47 66.3 µM 4.64E-12 NEO1 36 4.15E-14
18 SGTC_1376 2910-0861 7.36 41.3 µM 9.18E-12 3 9.32E-14
19 SGTC_2036 5160441 7.30 105.0 µM 1.29E-11 NEO1 33 1.39E-13
20 SGTC_208 k072-0098 7.27 12.4 µM 1.55E-11 heme biosynthesis & mitochondrial translocase 7 1.73E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.585 1.88E-306 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.542 2.03E-255 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.504 3.86E-215 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.491 9.67E-203 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.467 2.86E-181 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.463 1.15E-177 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.459 1.33E-174 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.459 7.15E-174 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.426 1.65E-147 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.425 2.97E-147 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.420 7.53E-143 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.417 4.27E-141 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.399 3.64E-128 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.369 2.74E-108 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.368 5.39E-108 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion