YDR387C_p

Putative transporter, member of the sugar porter family; YDR387C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR387C / YDR387C

Click on Significant Values for Screen Details ID:SGTC_349|Compound:k015-0014|FD-Score:2.99|P-value:3.36E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.51|P-value:1.33E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:-9.04|P-value:3.54E-25 ID:SGTC_359|Compound:0081-0058|FD-Score:-2.88|P-value:5.10E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.70|P-value:1.20E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.99|P-value:3.17E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.77|P-value:7.75E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.24|P-value:1.28E-9 ID:SGTC_536|Compound:3852-0578|FD-Score:3.37|P-value:6.50E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.26|P-value:1.06E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.34|P-value:7.30E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:2.75|P-value:9.05E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.21|P-value:1.35E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.93|P-value:4.12E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.82|P-value:6.64E-6 ID:SGTC_1739|Compound:st037196|FD-Score:2.88|P-value:5.46E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-2.78|P-value:7.44E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.06|P-value:2.40E-4 ID:SGTC_2316|Compound:5844804|FD-Score:6.76|P-value:7.52E-15 ID:SGTC_2326|Compound:6164455|FD-Score:3.96|P-value:3.35E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-2.82|P-value:6.40E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.06|P-value:1.81E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.67|P-value:1.55E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.61|P-value:2.03E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.83|P-value:6.83E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-3.72|P-value:1.08E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-4.48|P-value:1.59E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.97|P-value:3.14E-6 ID:SGTC_2930|Compound:9013230|FD-Score:2.94|P-value:4.26E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.28|P-value:9.57E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-2.73|P-value:8.99E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.75|P-value:8.45E-4 ID:SGTC_3072|Compound:9116419|FD-Score:2.74|P-value:9.13E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.05|P-value:2.60E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.39|P-value:5.82E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:2.99|P-value:3.36E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.51|P-value:1.33E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:-9.04|P-value:3.54E-25 ID:SGTC_359|Compound:0081-0058|FD-Score:-2.88|P-value:5.10E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.70|P-value:1.20E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.99|P-value:3.17E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.77|P-value:7.75E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:5.24|P-value:1.28E-9 ID:SGTC_536|Compound:3852-0578|FD-Score:3.37|P-value:6.50E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.26|P-value:1.06E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.34|P-value:7.30E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:2.75|P-value:9.05E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.21|P-value:1.35E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.93|P-value:4.12E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.82|P-value:6.64E-6 ID:SGTC_1739|Compound:st037196|FD-Score:2.88|P-value:5.46E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-2.78|P-value:7.44E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.06|P-value:2.40E-4 ID:SGTC_2316|Compound:5844804|FD-Score:6.76|P-value:7.52E-15 ID:SGTC_2326|Compound:6164455|FD-Score:3.96|P-value:3.35E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-2.82|P-value:6.40E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.06|P-value:1.81E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.67|P-value:1.55E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.61|P-value:2.03E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.83|P-value:6.83E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-3.72|P-value:1.08E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-4.48|P-value:1.59E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.97|P-value:3.14E-6 ID:SGTC_2930|Compound:9013230|FD-Score:2.94|P-value:4.26E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.28|P-value:9.57E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-2.73|P-value:8.99E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.75|P-value:8.45E-4 ID:SGTC_3072|Compound:9116419|FD-Score:2.74|P-value:9.13E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.05|P-value:2.60E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.39|P-value:5.82E-5

Top fitness defect scores for YDR387C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2316 5844804 6.76 197.4 µM 7.52E-15 4 7.03E-12
2 SGTC_534 k292-0788 5.24 63.4 µM 1.28E-9 mitochondrial processes 5 8.08E-8
3 SGTC_2880 9042983 3.97 58.4 µM 3.14E-6 fatty acid desaturase (OLE1) 24 3.54E-5
4 SGTC_2326 6164455 3.96 177.6 µM 3.35E-6 mitochondrial processes 22 3.73E-5
5 SGTC_2824 7998404 3.83 52.0 µM 6.83E-6 37 6.50E-5
6 SGTC_2568 diosmetin 3.67 100.0 µM 1.55E-5 30 1.23E-4
7 SGTC_2569 tetrandrine 3.61 100.0 µM 2.03E-5 32 1.52E-4
8 SGTC_3278 9139605 3.39 49.5 µM 5.82E-5 30 3.48E-4
9 SGTC_536 3852-0578 3.37 10.6 µM 6.50E-5 49 3.80E-4
10 SGTC_647 0140-0236 3.34 81.0 µM 7.30E-5 22 4.16E-4
11 SGTC_2989 9073649 3.28 71.4 µM 9.57E-5 72 5.14E-4
12 SGTC_548 1436-0017 3.26 110.0 µM 1.06E-4 TSC3-RPN4 63 5.59E-4
13 SGTC_894 0960-0238 3.21 55.9 µM 1.35E-4 30 6.75E-4
14 SGTC_2537 larixol 3.13 68.9 µM 1.86E-4 63 8.65E-4
15 SGTC_3146 9095609 3.13 49.5 µM 1.86E-4 49 8.66E-4
16 SGTC_3154 9100113 3.05 49.5 µM 2.60E-4 71 0.00113
17 SGTC_349 k015-0014 2.99 24.0 µM 3.36E-4 65 0.00138
18 SGTC_2930 9013230 2.94 14.9 µM 4.26E-4 heme biosynthesis & mitochondrial translocase 100 0.00166
19 SGTC_1739 st037196 2.88 92.5 µM 5.46E-4 76 0.00202
20 SGTC_875 0709-0210 2.75 25.7 µM 9.05E-4 fatty acid desaturase (OLE1) 95 0.00301

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.33E-25 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.163 2.29E-21 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.154 2.69E-19 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.142 1.70E-16 YLR285C-A_p YLR285C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.137 1.49E-15 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.128 8.94E-14 YGL139W FLC3 hom Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
0.128 1.15E-13 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.127 1.74E-13 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.122 1.31E-12 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.118 7.48E-12 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.117 1.05E-11 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.116 1.48E-11 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.109 2.15E-10 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.109 2.41E-10 YLL057C JLP1 hom Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.106 8.22E-10 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication