YDR400W / URH1

Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR400W / URH1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.05|P-value:5.96E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.26|P-value:2.66E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.24|P-value:2.76E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.42|P-value:1.39E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.95|P-value:1.33E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.50|P-value:9.56E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.02|P-value:6.55E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.95|P-value:8.58E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.25|P-value:2.78E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.99|P-value:7.14E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.17|P-value:3.69E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.03|P-value:8.86E-6 ID:SGTC_1675|Compound:st018485|FD-Score:-3.56|P-value:7.37E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.32|P-value:2.08E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.33|P-value:2.01E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.21|P-value:3.17E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.66|P-value:4.77E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.38|P-value:1.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.12|P-value:5.70E-6 ID:SGTC_2570|Compound:licareol|FD-Score:2.93|P-value:9.01E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.33|P-value:1.89E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.14|P-value:4.13E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.01|P-value:6.57E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.11|P-value:4.54E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.99|P-value:1.03E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-3.83|P-value:2.19E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.27|P-value:2.56E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.01|P-value:6.72E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-4.16|P-value:4.53E-6 ID:SGTC_39|Compound:0986-0283|FD-Score:3.05|P-value:5.96E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.26|P-value:2.66E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.24|P-value:2.76E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.42|P-value:1.39E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.95|P-value:1.33E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.50|P-value:9.56E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.02|P-value:6.55E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.95|P-value:8.58E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.25|P-value:2.78E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.99|P-value:7.14E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.17|P-value:3.69E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.03|P-value:8.86E-6 ID:SGTC_1675|Compound:st018485|FD-Score:-3.56|P-value:7.37E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.32|P-value:2.08E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.33|P-value:2.01E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.21|P-value:3.17E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.66|P-value:4.77E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.38|P-value:1.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.12|P-value:5.70E-6 ID:SGTC_2570|Compound:licareol|FD-Score:2.93|P-value:9.01E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.33|P-value:1.89E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.14|P-value:4.13E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.01|P-value:6.57E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.11|P-value:4.54E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.99|P-value:1.03E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-3.83|P-value:2.19E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.27|P-value:2.56E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.01|P-value:6.72E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-4.16|P-value:4.53E-6

Top fitness defect scores for YDR400W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1501 4491-0275 4.03 38.4 µM 8.86E-6 8 2.73E-5
2 SGTC_815 1582-0027 3.95 36.9 µM 1.33E-5 26 3.91E-5
3 SGTC_824 1304-0008 3.49 100.0 µM 1.02E-4 DNA damage response 53 2.40E-4
4 SGTC_686 1319-0111 3.42 510.0 µM 1.39E-4 60S ribosome export 44 3.16E-4
5 SGTC_2335 9018011 3.38 154.2 µM 1.62E-4 44 3.62E-4
6 SGTC_1748 st037455 3.34 53.6 µM 1.89E-4 57 4.16E-4
7 SGTC_1975 st070967 3.33 30.8 µM 2.01E-4 55 4.38E-4
8 SGTC_1701 st028638 3.32 40.4 µM 2.08E-4 31 4.51E-4
9 SGTC_3195 9113082 3.27 49.5 µM 2.56E-4 35 5.43E-4
10 SGTC_415 dibenzyl ketone 3.26 100.0 µM 2.66E-4 33 5.64E-4
11 SGTC_1230 0170-0365 3.25 3.8 µM 2.78E-4 endomembrane recycling 111 5.85E-4
12 SGTC_2108 5365811 3.21 200.0 µM 3.17E-4 45 6.57E-4
13 SGTC_1467 k284-1082 3.17 293.0 µM 3.69E-4 42 7.53E-4
14 SGTC_39 0986-0283 3.05 58.4 µM 5.96E-4 calcium & mitochondrial duress 77 0.00115
15 SGTC_1179 1021-1431 3.02 9.3 µM 6.55E-4 93 0.00126
16 SGTC_3233 9132340 3.01 49.5 µM 6.72E-4 60 0.00129
17 SGTC_1214 0358-0031 2.95 63.7 µM 8.58E-4 59 0.00160
18 SGTC_2570 licareol 2.93 100.0 µM 9.01E-4 77 0.00167
19 SGTC_1470 k295-0292 2.86 231.0 µM 0.00118 57 0.00213
20 SGTC_3003 9075612 2.82 71.4 µM 0.00137 71 0.00242

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.10E-19 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.130 3.89E-14 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.130 4.07E-14 YLR024C UBR2 hom Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
0.111 1.07E-10 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.111 1.20E-10 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.106 8.20E-10 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.103 2.14E-9 YKL108W SLD2 het Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
0.099 8.36E-9 YIL173W VTH1 hom Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
0.095 4.35E-8 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.094 4.33E-8 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.094 5.72E-8 YGR080W TWF1 hom Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
0.093 7.04E-8 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.092 1.02E-7 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.090 1.70E-7 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.085 7.86E-7 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel